Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Mutations of KRAS, TP53 and NF1 were found at an increasing frequency from AIS/MIA to ADC. 31747302 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Cases of UDEC had mutations in genes associated with endometrial adenocarcinomas (eg, TP53, PTEN, PIK3CA) and occasionally SMARCA4, while SDUS was characterized solely by inactivating mutations in SMARCA4. 31567195 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE The presence of aneuploidy, p53 positivity and development of HGD or adenocarcinoma on follow-up indicate that CCA likely represents a dysplastic lesion (at least LGD) and is a histological marker of neoplastic progression. 31111543 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Despite the propensity for gastric and esophageal adenocarcinomas to select for recurrent missense mutations in TP53, the precise functional consequence of these mutations remains unclear. 31391338 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE High-level p53 immunostaining in patients with AC was associated with advanced tumor (P=0.019) and Union for International Cancer Control stages (P=0.004), grading (P=0.027) and the resection margin status (P=0.006). 30881503 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE We investigated the expression patterns of Ki67 and p53 in metastatic pancreatic adenocarcinomas and analyzed their relationship with disease progression-free survival (PFS) and overall survival (OS) in the overall study population and in patients treated with a gemcitabine-containing chemotherapy versus FOLFIRINOX chemotherapy. 30187215 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Depletion of growth factors or concurrent Trp53 deletion resulted in its robust enrichment, invariably leading to development of PanIN or large high-grade adenocarcinoma, respectively, consistent with in vivo mouse studies for the same genotype. 31233118 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE p65BTK was significantly over-expressed in EGFR-wild type (wt) adenocarcinomas (AdC) from non-smoker patients and its expression was also preserved at the metastatic site. p65BTK was also over-expressed in cell lines mutated for KRAS or for a component of the RAS/MAPK pathway and in tumors from Kras/Trp53 null mice. 31200752 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE The interface between "adenocarcinoma" and "hyperplastic polyp" components was fairly sharp, and the adenocarcinoma components had copy number alterations and TP53 mutations, whereas the hyperplastic polyp components had only single nucleotide polymorphisms, which were also found in adenocarcinoma components. 31250201 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE The expression of p53 in adenocarcinoma was generally higher than that of squamous cell carcinoma and large cell carcinoma. 31186777 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE <b>Results:</b> p16 and p53 were detected in 50.7 and 57.3% of adenocarcinoma (ADCs; n = 75), and 35.2 and 63.6% of squamous cell carcinoma (n = 88). 31157548 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Finally, we screened colorectal cancer patients and identified recurrent somatic PPM1D mutations in a fraction of colon adenocarcinomas that are p53 proficient and show defects in mismatch DNA repair. 31659152 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE The binding of p53 to this region was confirmed using chromatin immunoprecipitation in human Friedreich's ataxia fibroblast and adenocarcinoma cells. 31159174 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE While PTEN inactivation leads to PC, it is not sufficient for metastasis, the loss of PTEN concurrently with the inactivation of both TP53 and RB1 empower lineage plasticity in PC cells, which substantially promotes PC metastasis and the conversion to PC adenocarcinoma to neuroendocrine PC (NEPC), demonstrating the essential function of TP53 and RB1 in the suppression of PCSCs. 30934773 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE In the adenocarcinoma KRAS-mutated group poor survival appeared to be linked to concomitant TP53 or STK11 mutations, and not to KRAS mutation as a single aberration. 30885352 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE There was a dramatic decrease in mutant p53 protein accumulation in the pancreatic acini, pancreas intraepithelial neoplasia lesions, and adenocarcinoma. 31397499 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Furthermore, the score was able to predict recurrence-free survival in patients with stage I adenocarcinoma and was also associated with smoking status.<b>Conclusions:</b> The P53 deficiency score was a better predictor of recurrence-free survival compared with P53 mutation status and provided additional prognostic values to established clinical factors.<b>Impact:</b> The P53 deficiency score can be used to stratify early-stage patients into subgroups based on their risk of recurrence for aiding physicians to decide personalized therapeutic treatment. 29141854 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Variations in the TP53 gene were seen in all NSCLC subtypes, including six ADC (13.63%), seven SCC (15.9%) and two LCC (4.54%). 30048458 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Further, these taxa, including Acidovorax, exhibit higher abundance among the subset of squamous cell carcinoma cases with TP53 mutations, an association not seen in adenocarcinomas. 30143034 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Of the 68 cases analyzed, there were only 3 tumors positive for p53 staining, all of which were adenocarcinoma. 29956011 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Multiple mutations were significantly associated with younger age (p = 0.0006), female sex (p = 0.012), smoking status (p = 0.002) and adenocarcinoma histology (p = 0.0001).TP53, KRAS and EGFR were the most common mutations. 30089591 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE MLL2 and KRAS mutations were only seen in adenocarcinoma ex goblet cell carcinoids and TP53 mutations were limited to poorly differentiated adenocarcinoma ex goblet cell carcinoids (2/34). 29422640 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Esophageal adenocarcinomas have mutations in tumor protein p53 and mutations that activate receptor-associated tyrosine kinase, vascular endothelial growth factor, and cell cycle pathways, whereas esophageal squamous tumors have a distinct set of mutations. 29037469 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE We found EGFR expression is higher in the squamous cell carcinomas than in adenocarcinomas (p=0.043), and that nuclear p53 staining correlated with lower differentiated squamous tumors (p=0.034). 29731995 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Immunohistochemically, the adenocarcinomas were positive for MUC6 (4/5), PAX8 (3/5), CK7 (5/5), CK20 (1/5), CDX2 (5/5), CA19.9 (5/5), CEA (4/5), CA125 (5/5), and hepatocyte nuclear factor 1β (5/5). p16, estrogen receptor, and Napsin A were negative in all cases tested, whereas p53 exhibited mutation-type staining in 3/5 cases. 29664741 2018