Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker group BEFREE The preoperative free thyroxine, thyroxine, GH, IGF-1, follicular-stimulating hormone, and luteinizing hormone levels were significantly lower in the giant adenoma group (n = 43) than in the large adenoma group (n = 121). 30880207 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 AlteredExpression group BEFREE Larger initial adenoma size (odds ratio [OR] 12.0, 95% confidence interval [CI] 1.02-141.3; p = 0.048) and high post-operative IGF-1 levels (OR 4.5, 95% CI 1.1-19.2; p = 0.040) were predictors for non-full remission and uncontrolled disease, respectively. 30141524 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker group BEFREE IGF-1 was found to have a significant and negative correlation with adenoma median long- and short-axis length. 29975581 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 AlteredExpression group BEFREE IGF-1 levels may increase to clinically significant levels during cabergoline treatment for PRL-adenoma. 29728863 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker group BEFREE Univariate analyses confirmed that sGHD recovery improved significantly in patients that were younger, had only undergone a single primary surgery, had not had anterior hormone deficiency except GH, and had cystic adenoma or normal insulin-like growth factor-1 (IGF1) standard deviation score (SD-S) levels immediately after surgery. 29910227 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 AlteredExpression group BEFREE We examined the association of circulating levels of IGF-1, IGFBP-3 and IGFBP-1, and SNPs in the IGF-1 receptor (IGF1R), IGF-2 receptor (IGF2R), and insulin receptor genes with risk of adenomas in a sample of 410 incident adenoma cases and 1,070 controls from the Case Transdisciplinary Research on Energetics and Cancer (TREC) Colon Adenomas Study. 24194259 2014
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 AlteredExpression group BEFREE Recent data suggest that soluble Klotho (sKlotho), besides and in addition to IGF-1, may help monitor the activity of GH-producing adenomas (presumably reflecting GH action on the kidneys) and may be a useful supplementary tool. 23648743 2013
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker group BEFREE The E-cadherin level correlated positively to tumor reduction after SMS treatment, and adenomas with nuclear E-cadherin staining had lower IGF-I reduction and tumor shrinkage. 20335450 2010
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 AlteredExpression group BEFREE IGF-IR expression was significantly higher in pediatric adrenocortical carcinomas than adenomas (9.1 +/- 3.1 vs. 2.6 +/- 0.3; P = 0.0001), whereas its expression was similar in adult adrenocortical carcinomas and adenomas. 18611974 2008
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 AlteredExpression group BEFREE Males showed plurihormonal focal pituitary transgene expression with LH-, TSH-, and, unexpectedly, also GH-cell focal hyperplasia and adenoma, associated with increased serum LH, GH, testosterone, and/or IGF-I levels. 15677710 2005
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 GeneticVariation group BEFREE Somatostatin and lanreotide inhibited cell proliferation in phorbol ester (PMA)-stimulated conditions (10/13 adenomas), as well as after fetal calf serum (3/3 adenomas) or IGF-I stimulation (2/2 adenomas). 12807513 2003
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 AlteredExpression group BEFREE We considered patients as "poorly controlled" who still showed elevated GH and IGF-I plasma levels, uninhibited GH after OGTT (GH > 1 microg/l), presence of clinical activity and/or radiological signs of adenoma recurrence, even if a reduction of tumor size had been demonstrated. 11972303 2002
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 AlteredExpression group BEFREE A corresponding up-regulation of IGF-1 mRNA was documented in carcinomas, whereas adenomas exhibited down-regulated expression of IGF-1 mRNA. 10937058 2000
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker group BEFREE These findings suggest that the attenuation of negative feedback through the pituitary GH-IGF-I axis may be involved in development of GH-producing adenoma. 10498342 1999
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker group BEFREE Cryosectioned normal human adrenal glands (n = 6), cortical adenoma (n = 21), and carcinoma (n = 17) were stained immunohistochemically for IGF-1 and its receptor, and human adrenocortical cancer cells expressing the receptor were analysed for influences on proliferation. 8669808 1996
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.400 Biomarker group CTD_human Hepatobiliary and gastrointestinal manifestations of acromegaly. 1611713 1992