Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Expression profiling of apoptosis-related genes along the crypt-villus axis and in Apc mutant adenomas revealed increased expression of two pro-apoptotic Bcl-2 family members in intestinal adenomas, Bok and Bax. 21184732 2011
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE Finally, we found the downstream genes activated by K-ras oncogene, including B-cell CLL/lymphoma 2 (BCL2), Homo sapiens H2A histone family, member Z (H2AFZ), Homo sapiens RAP1B, member of RAS oncogene family (RAP1B), Homo sapiens T-box 19 (TBX19), Homo sapiens E2F transcription factor 4, p107/p130-binding (E2F4) and matrix metallopeptidase 1 (MMP1), of which were overexpressed in most of all examined adenomas. 17089045 2006
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Interestingly, an inverse correlation was found between expression of pSer70 Bcl-2 and Ki-67 antigen in those cases of cancer in adenoma (P < 0.01). 16243795 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Apoptosis was also significantly lower in serrated than in tubulovillous adenomas, but higher than in hyperplastic polyps. p53 oncoprotein expression was significantly greater in both serrated and tubulovillous adenomas than in hyperplastic polyps. bcl-2 protein expression was higher only in tubulovillous adenomas. 15751053 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE Because the majority of colon carcinomas are known to overexpress antiapoptotic proteins such as survivin and Bcl-2 and show only limited ability to undergo apoptosis, we hypothesized that the ability of sulindac to cause regression of adenomas and to inhibit colon carcinogenesis is mediated, at least in part, by down-regulation of one or more of these antiapoptotic proteins. 14610217 2004
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE The molecular phenotype, p27(+)Bcl-2(+)Ki-67(-)mdm2(+), was observed in 76%, 29%, and 0% of typical and atypical adenomas and carcinomas, respectively. 12605367 2003
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 GeneticVariation group BEFREE 56 adenomas (< or = 10 mm) from 39 patients were analysed for APC, CTNNB1 and K-ras mutations, allelic imbalance on 1p and 18q, microsatellite instability and immunohistochemical expression of HLA-DR, BAX, BCL-2 and Ki-67. 12737446 2003
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE The expression of bcl-2 protein was gradually and significantly lost during the progression from moderately dysplastic adenoma to primary CRC (moderate/severe dysplasia: Mann-Whitney U-test, p=0.0001; severe dysplasia/primary CRC: p=0.027), whereas the cellular expression of bcl-2 mRNA was gradually increased during the dysplasia/adenoma-carcinoma neoplastic sequence. 10767713 2000
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE They included 36 cases with adenoma, 33 with low potential malignancy (LPM) and 63 with carcinomas. bcl-2 expression was observed in 14 of 36 cases (39%) with adenoma, five of 33 (15%) with LPM (P< 0.05) and 12 of 63 (19%) with carcinoma (P < 0.05). 10780525 2000
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Bcl2 expression in adenomas was stronger than in carcinomas; p53 expression was converse and p21 expression was variable. 11194193 2000
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE The bcl-w, bcl-2 and bcl-x(L)genes were over-expressed in nine, five and six of 12 adenomas and in five, two and seven of 11 carcinomas, respectively. 10944610 2000
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group CTD_human Results suggest that modulation of aberrant beta-catenin expression occurs during NSAID-induced regression of intestinal adenomas and that Bcl-2 may confer resistance to these effects. 10223192 1999
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group CTD_human Of the acidophilic lesions, the majority of foci (28/32, 88%) and adenomas (47/50, 94%) expressed increased bcl-X(L), whereas increased bcl-2 was observed in only 12.5% of acidophilic preneoplastic foci (4/32) and 14% of acidophilic adenomas (7/50). 10426811 1999
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE However, induction of apoptosis, associated with increased p53 protein expression but not with changes in Bcl-2 expression, was only detected in the adenoma derived BH/C1 and AA/C1 cell lines which express wild type p53 activity. 10359525 1999
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Immuno-histochemical (IHC) staining expression of bcl-2 and Ki67 was retrospectively investigated in a series of 52 colorectal carcinomas and 56 adenomas according to the avidin-biotin-complex method. 10607921 1999
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE p53 protein was detected in 43% and bcl-2 in 93% of the 76 rectosigmoid adenomas. 9672345 1998
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Weak p53 expression was in full thickness of dysplastic epithelium. p21 and bcl2 expression in adenoma was higher than in intestinal type of carcinoma. 9651943 1998
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE In general, BCL-2 expression was significantly stronger in the adenoma than in non-neoplastic mucosa and carcinoma, although there was no significant difference of ISTR-labeling between adenoma and carcinoma. 8563932 1995
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE BCL-2 protein was expressed in 19/22 adenocarcinomas and 12/13 adenomas. 7936663 1994
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE As controls, fetal and adult normal thyroid glands and adenomas were analysed. bcl-2 expression was detected in 74 of 94 cases (78.7 per cent) of WDC, 16 of 19 cases (84.2 per cent) of PDC, and 3 of 22 cases (13.6 per cent) of UC. 8207614 1994