Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2623
Gene Symbol: GATA1
GATA1
0.290 Biomarker disease BEFREE Although GATA1 is not mutated in PMF, reduced GATA1 content in megakaryocytes as a consequence of ribosomal deficiency is a hallmark of myelofibrosis (both in humans and mouse models) and, in fact, a driving event in the disease. 31749302 2020
Entrez Id: 2623
Gene Symbol: GATA1
GATA1
0.290 GeneticVariation disease BEFREE However, myelofibrosis and the significant frequency of dry taps have hampered practical screening of GATA1 mutations using bone marrow (BM) samples. 31606922 2020
Entrez Id: 2623
Gene Symbol: GATA1
GATA1
0.290 AlteredExpression disease BEFREE Previous studies have demonstrated a low level of GATA-1 expression in megakaryocytes from patients with MF. 30889303 2019
Entrez Id: 2623
Gene Symbol: GATA1
GATA1
0.290 Biomarker disease BEFREE GATA1 insufficiencies in primary myelofibrosis and other hematopoietic disorders: consequences for therapy. 29400094 2018
Entrez Id: 2623
Gene Symbol: GATA1
GATA1
0.290 AlteredExpression disease BEFREE Importantly, expression of GATA1 effectively rescued maturation of PMF megakaryocytes. 28240607 2017
Entrez Id: 2623
Gene Symbol: GATA1
GATA1
0.290 AlteredExpression disease BEFREE As mice carrying the hypomorphic Gata1<sup>low</sup> mutation, which reduces the levels of Gata1 mRNA in megakaryocytes, develop MF, we investigated whether the TPO axis is hyperactive in this model. 28622305 2017
Entrez Id: 2623
Gene Symbol: GATA1
GATA1
0.290 Biomarker disease BEFREE These data identify altered expression signatures of TGF-β1 signaling that may be responsible for MF in Gata1(low) mice and may represent additional targets for therapeutic intervention in PMF. 23462118 2013
Entrez Id: 2623
Gene Symbol: GATA1
GATA1
0.290 GeneticVariation disease BEFREE Spontaneous remission in 2 children with myelofibrosis, one with megakaryocytic acute myeloblastic leukemia and t(1;22) (with recurrence later) and one with Down syndrome and GATA1 mutation (permanent), are described. 22627572 2012
Entrez Id: 2623
Gene Symbol: GATA1
GATA1
0.290 Biomarker disease BEFREE Similar abnormalities in the SDF-1/CXCR4 axis are observed in PMF patients and in the Gata1 low mice model of myelofibrosis. 18206727 2008
Entrez Id: 2623
Gene Symbol: GATA1
GATA1
0.290 Biomarker disease LHGDN Similar abnormalities in the SDF-1/CXCR4 axis are observed in PMF patients and in the Gata1 low mice model of myelofibrosis. 18206727 2008
Entrez Id: 2623
Gene Symbol: GATA1
GATA1
0.290 Biomarker disease MGD Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1(low) mice). 12149188 2002
Entrez Id: 2623
Gene Symbol: GATA1
GATA1
0.290 Biomarker disease MGD Accentuated response to phenylhydrazine and erythropoietin in mice genetically impaired for their GATA-1 expression (GATA-1(low) mice). 11342429 2001