Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.500 GeneticVariation disease BEFREE In primary MF, inferior OS was associated with male gender (P = 0.03), haemoglobin < 10 g/dL (P = 0.002), platelet count < 100 × 10<sup>9</sup>/L (P = 0.02), TET2 mutation (P = 0.01) and CUX1 mutation (P = 0.01); and inferior LFS was associated with haemoglobin < 10 g/dL (P = 0.02), platelet count < 100 × 10<sup>9</sup>/L (P = 0.02), TET2 mutations (P = 0.01) and CUX1 mutations (P = 0.04). 30515541 2019
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.500 GeneticVariation disease BEFREE We found that blast phase of PV was characterized by overt myelodysplasia (n = 51, 88%); moderate to severe myelofibrosis (33 of 45, 73%); an abnormal karyotype (n = 51, 88%) that was often complex karyotype (n = 42, 72%); and gene mutations involving TP53 (55%), TET2 (27%), and DNMT3A (25%). 29285580 2018
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.500 GeneticVariation disease BEFREE Contrarily, DNA methylation genes (DNMT3A, IDH1, IDH2 and TET2) were mutated most often in PV (0·5) and less frequently in ET (0·23) and PMF (0·20), but without reaching statistical significance. 27447873 2016
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.500 GeneticVariation disease BEFREE Our previous study (unpublished data) showed that there was a high frequency distribution in rs3733609 C/T genotype at Ten-Eleven Translocation 2 (TET2) locus in one Chinese familial primary myelofibrosis. 26843622 2016
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.500 GeneticVariation disease BEFREE These results show epigenetic differences between PMF and polycythemia vera/essential thrombocytosis and reveal methylomic signatures of ASXL1 and TET2 mutations. 23066032 2013
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.500 GeneticVariation disease BEFREE No primary myelofibrosis patients (n = 6) harboured TET2 mutations. 23781511 2013
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.500 GeneticVariation disease BEFREE We have studied the mutational status of TET2 (complete coding region), ASXL1 (exon12), IDH1 (R132), IDH2 (R140 and R172), and c-CBL (exons 8 and 9) in 62 MPN patients (52 essential thrombocythemia (ET), five polycythemia vera (PV), and five primary myelofibrosis (PMF)) negative for both JAK2 (V617F and exon 12) and MPL (exon 10) mutations. 21904853 2012
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.500 GeneticVariation disease BEFREE In addition to the JAK2V617F mutation, different genetic markers have recently been discovered in PMF, the most relevant ones being the mutations in the thrombopoietin (MPL), TET2, and EZH2 genes. 21892083 2011
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.500 GeneticVariation disease BEFREE TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. 19262601 2009
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.500 GeneticVariation disease BEFREE TET2 mutations were mainly observed (10 of 12) in patients with primary myelofibrosis or patients with polycythemia vera or essential thrombocythemia who secondarily evolved toward myelofibrosis or acute myeloid leukemia. 19564637 2009
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.500 SomaticCausalMutation disease ORPHANET TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. 19262601 2009
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.500 SomaticCausalMutation disease ORPHANET TET2 mutations in myelodysplasia and myeloid malignancies. 19557078 2009
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.500 Biomarker disease HPO