Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.060 Biomarker disease BEFREE Accordingly, primary myelofibrosis (MF) patient cells demonstrate an increased CXCL12-induced chemotaxis when compared to controls. 28903325 2017
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.060 AlteredExpression disease BEFREE Expression of Hmga2 enhanced megakaryopoiesis, increased extramedullary hematopoiesis, and accelerated the development of MF in mice expressing Jak2<sup>V617F</sup> Mechanistically, the data show that expression of Hmga2 enhances the activation of transforming growth factor-β1 (TGF-β1) and Cxcl12 pathways in mice expressing Jak2<sup>V617F</sup> In addition, expression of Hmga2 causes upregulation of Fzd2, Ifi27l2a, and TGF-β receptor 2. 28637665 2017
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.060 AlteredExpression disease BEFREE Our data indicate that the MF splenic microenvironment is characterized by increased levels of intact, functional CXCL12, which contributes to the localization of MF CD34(+) cells to the spleen and the establishment of extramedullary hematopoiesis. 25461253 2015
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.060 Biomarker disease BEFREE Treatment of PMF CD34(+) cells with chromatin-modifying agents (CMAs) but not hydroxyurea, Janus kinase 2 (JAK2) inhibitors, or low doses of interferon-α led to the generation of greater numbers of CD34(+) chemokine (C-X-C motif) receptor (CXCR)4(+) cells, which were capable of migrating in response to chemokine (C-X-C motif) ligand (CXCL)12 and resulted in a reduction in the proportion of hematopoietic progenitor cells (HPCs) that were JAK2V617F(+). 20858855 2010
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.060 AlteredExpression disease BEFREE In fact, plasma SDF-1 levels in PMF patients were significantly higher (by twofold) than normal (p < 0.01) and SDF-1 immunostaining of marrow biopsy specimens demonstrated increased SDF-1 deposition in specific areas. 18206727 2008
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.060 Biomarker disease BEFREE 5-AzaD-treated PMF CD34(+) cells displayed almost complete reversal of CpG1 island 1 hypermethylation and showed enhanced migration in vitro in response to SDF-1. 18511598 2008
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.060 Biomarker disease LHGDN In fact, plasma SDF-1 levels in PMF patients were significantly higher (by twofold) than normal (p < 0.01) and SDF-1 immunostaining of marrow biopsy specimens demonstrated increased SDF-1 deposition in specific areas. 18206727 2008