Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 GeneticVariation disease BEFREE Later studies identified that PMF, as the others MPNs, is associated with mutations activating the thrombopoietin/JAK2 axis raising great hope that JAK inhibitors may be effective to treat the disease. 31749302 2020
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 Biomarker disease BEFREE The majority of cytokines elevated in MF exhibited ex vivo hypersensitivity to thrombopoietin (TPO), toll-like receptor (TLR) ligands, and/or tumor necrosis factor (TNF). 30718771 2019
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 Biomarker disease BEFREE Here we show that OGX-427 is effective in two murine models of thrombopoietin- and JAKV617F-induced myelofibrosis. 29650953 2018
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 Biomarker disease BEFREE We showed that TPO or a TPO receptor agonist directly induces fibrocyte differentiation using murine fibrocyte cell lines and a murine MF model. 28386106 2017
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 AlteredExpression disease BEFREE The thrombopoietin/MPL axis is activated in the Gata1<sup>low</sup> mouse model of myelofibrosis and is associated with a defective RPS14 signature. 28622305 2017
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 Biomarker disease BEFREE In this report, we show that although both splenic and peripheral blood MF CD34(+) cells expressed lower levels of MPL than normal CD34(+) cells, TPO promoted the proliferation of MF CD34(+) cells and HPCs in a dose-dependent fashion. 27114459 2016
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 PosttranslationalModification disease BEFREE Using Sparc(-/-) mice and BM chimeras, we demonstrate that SPARC contributes to the development of significant stromal fibrosis in a model of thrombopoietin-induced myelofibrosis. 22955913 2012
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 GeneticVariation disease BEFREE Acquired mutations in the juxtamembrane region of MPL (W515L or W515K), the receptor for thrombopoietin, have been reported in patients with primary essential thrombocythemia (ET) or primary myelofibrosis (PMF). 19274616 2010
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 GeneticVariation disease BEFREE To evaluate the frequency of MPL W515L, W515K and S505N mutations in essential thrombocythemia (ET) and primary myelofibrosis (PMF) and to determine whether MPLW515L leads to impaired Mpl expression, constitutive STAT3 and STAT5 activation and enhanced response to thrombopoietin (TPO). 20113333 2010
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 GeneticVariation disease BEFREE Acquired mutations in the juxtamembrane region of MPL (W515K or W515L), the receptor for thrombopoietin, have been described in patients with primary myelofibrosis or essential thrombocythemia, which are chronic myeloproliferative disorders. 18669880 2008
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 AlteredExpression disease BEFREE We also studied the same parameters in two mouse models of myelofibrosis, with genetic alterations affecting megakaryocyte differentiation (i.e. one model with low GATA-1 expression and the other with over-expression of thrombopoietin). 17488682 2007
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 GeneticVariation disease BEFREE Other recent observations of potential pathogenetic relevance in this disease include the description of a highly specific chromosomal translocation {der(6)t(1;6)(q23;p21)}, the demonstration of an epigenetic downregulation of the retinoic acid receptor-beta2 expression in CD34 cells, and the direct implication of transforming growth factor-beta1 in thrombopoietin-driven experimental myelofibrosis in mice. 16456374 2006
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 Biomarker disease BEFREE Involvement of transforming growth factor-beta and thrombopoietin in the pathogenesis of myelodysplastic syndrome with myelofibrosis. 16034467 2005
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 AlteredExpression disease BEFREE We found no increase of TPO mRNA production in either BM cells or in BM stromal cells in patients with MF and ET. 12479847 2003
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 Biomarker disease BEFREE In this study, we investigated whether Mpl-L was responsible for the pathogenesis of ET and PMF. 9864154 1999
Entrez Id: 7066
Gene Symbol: THPO
THPO
0.100 Biomarker disease BEFREE Taken together, our data show that high and persistent TPO production by transduced hematopoietic cells in mice results in a fatal myeloproliferative disorder that has a number of features in common with human idiopathic myelofibrosis. 9373248 1997