Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE Our findings did not reveal any major influence on SCZ and BPD development; On the other hand, some alteration of the SLC6A4 sequence were associated with an increased risk of ALC and ALZ disorders, suggesting common pathways. 31595439 2020
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE When patients with comorbid alcohol use disorder (AUD) were removed, given that TPH1 has been associated with alcoholism, the associations of those recovered from SI with TPH1 rs1799913 remained significant for the additive (increased recovery with AC, P = 0.045) and recessive (increased recovery with C-carriers, P = 0.008) models, and with 5-HTTLPR using the dominant model (increased recovery with S'S', P = 0.016). 30923939 2019
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE Our results do not replicate a previous finding that increased methylation in the promoter region of SLC6A4 is associated with threat-related amygdala activation in healthy individuals and further show that there is no such association in individuals with AD. 31008507 2019
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE This preliminary study, though on a smaller sample size, suggests an association of 5-HTTLPR and GABA<sub>A</sub> receptor polymorphisms with AD in our population. 29673739 2019
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE However, the ADS 5-HTTLPR genotype and allele distribution frequencies differ significantly by the variation in progression of ADS. 30708239 2019
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE Although our current understanding of the role of 5-HT systems in alcohol dependence is incomplete, there is some evidence to suggest that 5-HT3 receptor antagonists are effective in people with the L/L genotype of the 5-HTTLPR polymorphism while SSRIs may be more beneficial to people with the S/L or S/S genotype. 27161942 2016
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease BEFREE We review the AD typology and disease onset in the context of pharmacogenetic and genomic studies that examine the utility of 5-HTTLPR in improving treatment outcomes. 26311211 2016
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE Carrying a genetic variant in the serotonin transporter gene (5HTT) may increase the risk of major depressive disorder and alcohol dependence. 26979101 2016
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease BEFREE TPH1 and 5-HTTLPR Genes Specifically Interact in Opiate Dependence but Not in Alcohol Dependence. 27045756 2016
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE Comparing AD and control populations and taking into account statistical correction for multiple testing, we found no statistically significant differences for 5-HTTLPR (L/S) and rs25531 polymorphisms in terms of either genotypes or alleles frequencies. 25770138 2015
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease PSYGENET It is plausible that variations in genetically determined SLC6A4 activity may modify the risk for alcohol dependence. 25710844 2015
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease BEFREE Our findings suggest that bi- and triallelic SLC6A4 5-HTTLPR has some effects on the severity of alcohol dependence. 26352193 2015
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE It is plausible that variations in genetically determined SLC6A4 activity may modify the risk for alcohol dependence. 25710844 2015
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease PSYGENET Genetic analyses of the level of response to alcohol, particularly of the functional OPRM1 A118G polymorphism and 5' and 3' functional polymorphisms in SLC6A4, are beginning to provide insights into the etiology of alcoholism and also genotype-stratified subgroup responses to naltrexone and SSRIs/ondansetron respectively. 24220019 2014
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE Genetic analyses of the level of response to alcohol, particularly of the functional OPRM1 A118G polymorphism and 5' and 3' functional polymorphisms in SLC6A4, are beginning to provide insights into the etiology of alcoholism and also genotype-stratified subgroup responses to naltrexone and SSRIs/ondansetron respectively. 24220019 2014
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE These findings reveal significant interactive effects among variants in SLC6A4-HTR3A-HTR3B affecting AD. 23757001 2013
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease PSYGENET We previously reported moderating effects of age of onset of alcohol dependence (AD) and a functional polymorphism (5-HTTLPR) in the gene encoding the serotonin transporter protein in a sample of 134 individuals participating in a 12-week, placebo-controlled trial of sertraline. 23145795 2013
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease PSYGENET These findings reveal significant interactive effects among variants in SLC6A4-HTR3A-HTR3B affecting AD. 23757001 2013
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE We previously reported moderating effects of age of onset of alcohol dependence (AD) and a functional polymorphism (5-HTTLPR) in the gene encoding the serotonin transporter protein in a sample of 134 individuals participating in a 12-week, placebo-controlled trial of sertraline. 23145795 2013
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease PSYGENET Considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter, are involved in alcoholism and tobacco use and are influenced by polymorphism of the promoter region of 5HTT (5-HTTLPR). 22460318 2012
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE Our study suggests that neither the 5-HTTLPR gene nor the 5-HT1B G861C polymorphism alone is a risk factor for antisocial alcoholism in Taiwan's Han Chinese population, but that the interaction between both genes may increase susceptibility to antisocial alcoholism. 22550993 2012
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 Biomarker disease BEFREE The S allele has been associated with a variety of psychiatric disorders and symptoms including alcohol dependence, but it is unknown whether 5-HTTLPR increases the risk for co-morbid sociopathy among those with alcohol dependence. 20192950 2011
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE The HTR3B rs1176744 gain-of-function Ser129 allele predicted alcohol dependence (P=0.002) and low 5-HTTLPR activity predicted cocaine/heroin dependence (P=0.01). 20838391 2011
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE The aim of this study was to determine whether the serotonin transporter gene polymorphism (5-HTTLPR) is associated with the treatment outcomes of escitalopram for patients with comorbid major depression and alcohol dependence. 20800901 2011
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.600 GeneticVariation disease BEFREE We examined (1) the association of SLC6A4 genotypes and alcohol dependence (AD) in a sample of alcoholics; (2) the validity of lifetime occurrence of blacked-out violent impulsive behaviour (BOVIB) during binge drinking bouts as a criterion for subtyping AD patients and (3) a mechanistic hypothesis for BOVIB involving tryptophan-2,3-dioxygenase (TDO) activity. 19759277 2010