Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE In search for a treatment approach of AD, we found that inhibition of the angiotensin-converting enzyme (ACE) by a centrally acting ACE inhibitor retards symptoms of neurodegeneration, Abeta plaque formation and tau hyperphosphorylation in experimental models of AD. 30991105 2020
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 AlteredExpression disease BEFREE Phytol and Phytol-PLGA NPs treatment downregulated the expression of AD associated genes viz Aβ, ace-1 and hsp-4 and upregulated the gene involved in the longevity to nematodes (dnj-14) and it also reduced the expression of Aβ peptide at the protein level. 31734340 2020
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease CTD_human Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. 30820047 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 GeneticVariation disease BEFREE This study was aimed to estimate variations of measures of cardiovascular risk in Alzheimer's dementia by pharmacogenetic analyses of the effects of angiotensin-converting enzyme (ACE) inhibitors and statins. 31719297 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 AlteredExpression disease BEFREE These results suggest that inhibition of ACE activity is a risk factor for impaired human cognition and for triggering AD onset. 31072831 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 AlteredExpression disease BEFREE Moreover it altered the Aβ mediated pathways, lifespan, macromolecular damage and down regulated the AD related gene expression of ace-1, hsp-4 and Aβ, thereby preventing Aβ synthesis. 31362072 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE CSF ACE1 weakly correlated with t-tau (r = 0.294, p = 0.066) and p-tau (r = 0.329, p = 0.038) but not with Aβ42 in the controls but not in AD. 31594235 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 GeneticVariation disease GWASCAT GWAS on family history of Alzheimer's disease. 29777097 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE Overactivation of angiotensin-converting enzyme/angiotensin 2/angiotensin receptor-1 (ACE/Ang2/AT1) axis provokes amyloid-β-induced apoptosis and neurodegeneration in Alzheimer's disease (AD). 29516284 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease. 29321566 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE Pharmacogenetics of Angiotensin-Converting Enzyme Inhibitors in Patients with Alzheimer's Disease Dementia. 29034839 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE Angiotensin converting enzyme (ACE) is involved in proteolytic processing of the amyloid-β(Aβ) peptide implicated in the development of Alzheimer's disease (AD) and known products of ACE-based processing of Aβ42 are characterized by reduced aggregability and cytotoxicity. 30282362 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE We also discuss strategies that address each problem and draw on the experience of Fundació ACE to argue that focusing resources on comprehensive AD centers that offer coordinated clinical and social care and participate in basic and clinical research, is an effective and efficient way of implementing many of the discussed strategies. 29562541 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 AlteredExpression disease BEFREE Interestingly, ACE overexpression in monocytes, migrating to the brain was shown to prevent AD cognitive decline. 29765306 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE Our results strengthen the hypothesis that ACE is associated with Aβ pathology in AD. 30040721 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE Taken together, our study demonstrated that the deletion of CB2R reduces exogenous Aβ degradation and aggravates the toxicity of Aβ via the reduction of ACE and IDE, which suggests that CB2R is involved in the onset of AD and a potential therapeutic target for AD. 29991137 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE The renin-angiotensin system (RAS) has been implicated in AD, and thus RAS-acting AHTs (angiotensin converting enzyme inhibitors (ACEIs), and angiotensin-II receptor blockers (ARBs)) may offer differential and additional protective benefits against AD compared with other AHTs, in addition to hypertension management. 30383807 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 GeneticVariation disease BEFREE We measured Ang-II and Ang-III levels by ELISA, and the levels and activities of aminopeptidase-A (AP-A) and aminopeptidase-N (AP-N) (responsible for the production and metabolism of Ang-III, respectively) in human postmortem brain tissue in the mid-frontal cortex (Brodmann area 9) in a cohort of AD (n = 90) and age-matched non-demented controls (n = 59), for which we had previous measurements of ACE-1 activity, Aβ level, and tau pathology (also in the mid-frontal cortex). 28387670 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 GeneticVariation disease BEFREE The present study supports the hypothesis that the ACE I/D polymorphism is associated with the severity of WMC in patients with AD. 27273771 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 GeneticVariation disease BEFREE This 3-year observational study investigated the longitudinal effect of ACE I/D polymorphism on AD progression. 27862810 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE Recent findings have indicated possible associations of hypertension with AD progression, and suggest that angiotensin converting enzyme (ACE) inhibitors with potential to pass through the blood brain barrier (BBB) may reduce the risk of AD. 28158298 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE After a median survival time of 20.6 months, 85% from the ACE MCI converted to AD. 28269787 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE The co-administration of angiotensin converting enzyme inhibitors (ACEi) and angiotensin II (AngII) receptor blockers (ARB) that bind angiotensin type 1 receptors (AT1R) may protect from Alzheimer's disease (AD) better than each treatment taken alone. 26923013 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE Moreover, patients with aMCI could take ACE inhibitor (ACEI) to decrease the incidence of AD, and patients with AD could take ACEI to retard cognitive decline in early AD. 27608957 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.900 Biomarker disease BEFREE Together, our findings indicate that ACE-2 activity is reduced in AD and is an important regulator of the central classical ACE-1/Ang II/AT1R axis of RAS, and also that dysregulation of this pathway likely plays a significant role in the pathogenesis of AD. 27884212 2016