Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease. 31678156 2020
Entrez Id: 351
Gene Symbol: APP
APP
0.400 AlteredExpression disease BEFREE Somatostatin (SST) blocks the aggregation of and inflammation whereas reduction of SST levels in the CSF and brain tissue is associated with impaired cognitive function and memory loss. 29700775 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE The elevation of Rac1 activity not only accelerated 6-hour spatial memory decay in 3-month-old APP/PS1 mice, but also significantly contributed to severe memory loss in aged APP/PS1 mice. 31321704 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE More importantly, the Pt<sup>II</sup> -PW<sub>11</sub> greatly reduced Aβ deposition and rescued memory loss in APP/PS1 transgenic AD model mice without noticeable cytotoxicity, demonstrating its potential as drugs for AD treatment. 31591753 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE Here, we use the J20-APP AD mouse model that displays spatial memory loss as well as reduced slow gamma amplitude and phase-amplitude coupling to theta oscillations phase. 31757962 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to β-Amyloid peptide accumulation. 28801921 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.400 AlteredExpression disease BEFREE Treatment of 3xTg-AD mice with flavocoxid reduced: (1) learning and memory loss; (2) the increased eicosanoid production and the phosphorylation level of amyloid precursor protein (APP-pThr668), Aβ 1-42, p-tau (pThr181), pERK, and the activation of the NLRP3 inflammasome; (3) Aβ plaques; and (4) neuronal loss, compared to saline-treated animals. 28238167 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE Three months of treatment of AAV9-GFP-CIP reduced pathologic changes, including τ hyperphosphorylation, (Aβ) deposit, astrocytosis, and microgliosis, which were correlated with the reversal of memory loss and anxiety-like behavior observed in APP/PS1 mice. 28420695 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism. 27457810 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE APP/PS1 double-transgenic mice treated with 3F5 mAb showed reduced memory loss, cognitive decline, and decreased levels of amyloid deposits in the brain. 28662102 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.400 AlteredExpression disease BEFREE Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention. 27388605 2016
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE The amyloid precursor protein (APP) and its cleavage product Aβ play central roles in synapse and memory loss, and thus are strongly implicated in the pathogenesis of AD. 21199446 2012
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE The brain formaldehyde level in APP/PS1-transgenic (n=8) mice at age of 3 months and APP-transgenic (n=8) mice at age of 6 months was increased (0.56 ± 0.02 mM), respectively, as compared with their respective age-matched controls, when these two types of AD-like animals, respectively, started to form Aβ deposits and memory loss obviously. 19879019 2011
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE Transgene expression of familial Alzheimer's disease-linked mutants of β-amyloid precursor protein (APP) and presenilin-1 leads to a significant inhibition of neurogenesis, which is potentially linked to age-dependent memory loss. 22042871 2011
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE Functionally, removing CX3CR1 in human amyloid precursor protein mice worsened the memory retention in passive avoidance and novel object recognition tests, and their memory loss in the novel object recognition test is associated with high levels of interleukin 6. 21771791 2011
Entrez Id: 351
Gene Symbol: APP
APP
0.400 GeneticVariation disease BEFREE An increased amount or mutation(s) in PS1, which alters the stoichiometric balance of the gamma-secretase complex, may be the cause of aberrant or increased processing of APP, resulting in Abeta accumulation leading to loss of memory. 19181896 2009
Entrez Id: 351
Gene Symbol: APP
APP
0.400 GeneticVariation disease BEFREE The amyloid hypothesis does not adequately address the pathogenesis of the disease, however, since transgenic mice that express the pathologic mutations of the APP and presenilin-1 (PS1) genes produce amyloid plaques but fail to exhibit neurodegeneration and memory loss observed in AD patients. 17981591 2008
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE This suggests that the memory loss in APP+PS1 transgenic mice may model the early memory dysfunction in AD before the degeneration of synapses and neurons. 12832546 2003
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease CTD_human (2) To test whether dimemorfan has anti-amnesic effects similar to a sigma(1) receptor agonist, this study examined its effects on scopolamine- and beta-amyloid peptide-(25-35)-induced amnesia in mice.(3) Dimemorfan (10-40 mg kg(-1), i.p.) administered 30 min before the training trial, immediately after the training trial, or 30 min before the retention test significantly improved scopolamine (1 mg kg(-1), i.p.)- or beta-amyloid peptide-(25-35) (3 nmol mouse(-1), i.c.v.)-induced amnesia in a step-through passive avoidance test.Dimemorfan (5-40 mg kg(-1), i.p.) pretreatment also attenuated scopolamine (8 mg kg(-1), i.p.)-induced amnesia in a water-maze test. 12642396 2003
Entrez Id: 351
Gene Symbol: APP
APP
0.400 Biomarker disease BEFREE A significant component of memory loss in APP transgenic mice is apparently caused by soluble A Beta assemblies, but whether and how much of the dementia within individuals afflicted with AD is caused by these A Beta species is unclear. 11773429 2002
Entrez Id: 351
Gene Symbol: APP
APP
0.400 GeneticVariation disease BEFREE Transgenic mice which carried the mutant form of the beta-amyloid precursor protein gene expressed high concentrations of mutant copy of the gene and exhibited abundant amyloid plaques in the brain and memory loss. 9206974 1997