Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 AlteredExpression disease BEFREE Here, using biochemical and immunohistochemistry analyses we report that a 50% global reduction of BIN1 protein levels resulting from a single <i>Bin1</i> allele deletion in mice does not change BACE1 levels or localization <i>in vivo</i>, nor does this reduction alter the production of endogenous murine in nontransgenic mice. 30692199 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 AlteredExpression disease BEFREE These plant metabolites have been shown to ameliorate AD by increasing the expression of insulin degrading enzyme (IDE), neprilysin (NEP), PPAR-γ, and α-secretase, and decreasing the expression of β-secretase (BACE-1) to reduce the levels of oligomers (<sub>O</sub>) deposition in brain neurons. 30877973 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 AlteredExpression disease BEFREE The identified aptamers interacted with BACE1 in pull-down assay, inhibited BACE1 activity in in vitro fluorescence resonance energy transfer (FRET) assay and HEK293-APP stable cell line, reduced in the culture medium of HEK293-amyloid protein precursor (APP) stable cell line and APP-PS1 primary cultured neurons, and rescued -induced neuronal deficiency in APP-PS1 primary cultured neurons. 30959405 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 Biomarker disease BEFREE Amyloid precursor protein (APP) is processed along the amyloidogenic pathway by the β-secretase, BACE1, generating β-amyloid (Aβ), or along the nonamyloidogenic pathway by α-secretase, precluding production. 30545942 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 Biomarker disease BEFREE Aβ deposition in turn causes accumulation of BACE1 in plaque-associated dystrophic neurites, thereby potentiating progressive deposition once initiated. 31701556 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 Biomarker disease BEFREE β-Secretase (BACE1) and acetylcholinesterase (AChE), which are required for the production of neurotoxic β-amyloid (Aβ) and the promotion of fibril formation, respectively, are considered as prime therapeutic targets for AD. 30717208 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 Biomarker disease BEFREE Therefore, we conclude that Syn1 may promote production via the modulation of BACE1. 31830091 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 AlteredExpression disease BEFREE A combination of compound 2a with BACE IV also reduced levels in cells, more than the additive effect of the two compounds. 30873837 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 AlteredExpression disease BEFREE In addition, the levels of amyloid-β protein (Aβ), phosphorylated-tau (Ser396), malondialdehyde (MDA), interleukin 1-beta (IL-1β), tumor necrosis alpha (TNFα), p- Glycogen synthase kinase-3β (p-GSK3β) (Tyr216), and β-secretase (BACE1) gene expression were increased in socially isolated aluminum treated rats, yet, vinpocetine treatment reversed these deteriorating effects. 31175888 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 Biomarker disease BEFREE β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is required for the production of β-amyloid () peptides and is considered a potential treatment target for Alzheimer's disease (AD). 30347431 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 AlteredExpression disease BEFREE The present study confirmed this hypothesis by showing that PPARγ agonist pioglitazone attenuated the neuronal apoptosis of primary rat hippocampal neurons induced by <sub>1-42</sub>, downregulated CDK5 expression, weakened the binding of CDK5 to PPARγ, reduced PPARγ phosphorylation, increased the expression of PPARγ and IDE, decreased the expression of BACE1, reduced APP production, and downregulated intraneuronal Aβ<sub>1-42</sub> levels. 31379559 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 Biomarker disease BEFREE MicroRNA-200a-3p Mediates Neuroprotection in Alzheimer-Related Deficits and Attenuates Amyloid-Beta Overproduction and Tau Hyperphosphorylation <i>via</i> Coregulating BACE1 and PRKACB. 31379578 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 AlteredExpression disease BEFREE Transplantation of BDNF modified hUC-MSCs-derived cholinergic-like neurons significantly improved spatial learning and memory abilities in the AD rats, increased the release of acetylcholine and ChAT expression in the hippocampus, enhanced the activation of astrocytes and microglia, reduced the expression of and recombinant human beta-site APP-cleaving enzyme1 (BACE1), inhibited neuronal apoptosis, and promoted neurogenesis. 30586546 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 Biomarker disease BEFREE Inhibition of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) to prevent brain β-amyloid () peptide's formation is a potential effective approach to treat Alzheimer's disease. 31711785 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 AlteredExpression disease BEFREE This age-dependent shift in peptide profile coincided with reduced expression of glycosylated species of ADAM-10 (α-secretase) and BACE1 (β-secretase), and an increased co-immunoprecipitation of presenilin-1 with nicastrin (components of the γ-secretase complex). 30803762 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 Biomarker disease BEFREE Verubecestat is an orally administered β-site amyloid precursor protein-cleaving enzyme 1 (BACE-1) inhibitor that blocks production of amyloid-beta (Aβ). 30970186 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 Biomarker disease BEFREE The proteolytic enzyme β-secretase (BACE1) plays a central role in the synthesis of the pathogenic β-amyloid peptides (Aβ) in Alzheimer's disease (AD), antioxidants could attenuate the AD syndrome and prevent the disease progression. 31397505 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 AlteredExpression disease BEFREE With regard to a potential mechanism, in both models, we found that the stroke-induced and tau deposits co-localized with increased levels of β-secretase 1 (BACE1), along with its substrate, neuregulin 1 (NGR1) type III, both of which are proteins integral for myelin repair. 30249297 2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 AlteredExpression disease BEFREE Moreover, miR-16 overexpression and BACE1 knockdown facilitated -induced cell toxicity, apoptosis, and caspase-3 activity in N2a cells, which was partially eliminated by overexpression of BACE1. 30142113 2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 Biomarker disease BEFREE BACE1 inhibition in mice with lower amyloidosis at treatment initiation showed a higher efficacy in attenuating progression to PET. 30429879 2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 AlteredExpression disease BEFREE Focusing on the donor's sex and APOE ε4 status as nominal variables (i.e., omitting diagnosis from the stratification) revealed that increases in peptides were specific to female carriers of the ε4 allele and correlated with the proportional expression of BACE1/β-secretase and ADAM10/α-secretase in the cortex and with nicastrin (γ-secretase) expression in the hippocampus. 29331531 2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 Biomarker disease BEFREE The cerebrospinal fluid neurogranin (Ng)/β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) ratio may reflect synaptic affection resulting from reduced beta-amyloid () clearance. 30519627 2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 Biomarker disease BEFREE The protease Bace1 drives beta amyloid () production with obesity elevating hypothalamic Bace1 activity and <sub>1-42</sub> production. 29311632 2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 Biomarker disease BEFREE BACE1 is the rate-limiting protease in the production of synaptotoxic β-amyloid () species and hence one of the prime drug targets for potential therapy of Alzheimer's disease (AD). 29327084 2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.100 AlteredExpression disease BEFREE The naringenin loaded nanoemulsion significantly alleviated the direct neurotoxic effects of on SH-SY5Y cells; this was associated with a down-regulation of APP and BACE expression, indicating reduced amyloidogenesis. 30001606 2018