Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer's Disease. 31417361 2019
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Here, we have shown that NCAM1 peptide constructs carrying polycationic sequences derived from Aβ peptide (KKLVFF) and PrP protein (KKRPKP) significantly promote the S100A9 amyloid self-assembly in a concentration-dependent manner by making transient interactions with individual S100A9 molecules, perturbing its native structure and acting as catalysts. 31194501 2019
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Ultrasensitive Detection of Amyloid-β Using Cellular Prion Protein on the Highly Conductive Au Nanoparticles-Poly(3,4-ethylene dioxythiophene)-Poly(thiophene-3-acetic acid) Composite Electrode. 31373200 2019
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Structural Mechanism of Barriers to Interspecies Seeding Transmissibility of Full-Length Prion Protein Amyloid. 31161647 2019
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 GeneticVariation disease BEFREE It is not understood why specific mutations in the prion protein gene (PRNP) cause cerebral amyloidosis and others cause CJD. 29887140 2018
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Using paraffin-embedded sections, we applied histology and single- and multiple-labeling immunohistochemistry for PrP, p-tau, and to the three cases. 30240140 2018
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 GeneticVariation disease BEFREE An in situ labeling using biotinylated Tat 48-57 peptide was employed in the brain tissue with amyloid deposits made up of Aβ (patients with AD and transgenic AD mice), of prion protein (patients with Gerstmann-Straussler-Scheinker disease), and other amyloidosis, processed by different fixations and pretreatments of histological sections. 29349578 2018
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 GeneticVariation disease BEFREE Specific amyloid-β42 deposition in the brain of a Gerstmann-Sträussler-Scheinker disease patient with a P105L mutation on the prion protein gene. 30394185 2018
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Targeting glutamatergic and cellular prion protein mechanisms of amyloid β-mediated persistent synaptic plasticity disruption: Longitudinal studies. 28390893 2017
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 GeneticVariation disease BEFREE Species-dependent structural polymorphism of Y145Stop prion protein amyloid revealed by solid-state NMR spectroscopy. 28963458 2017
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro. 28373719 2017
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 GeneticVariation disease BEFREE This heterologous association induced aggregation of monomeric PrP and modified the structural properties of PrP amyloid fibrils. 25853328 2015
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models. 26018073 2015
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Soluble Amyloid-β oligomers (Aβo) can trigger Alzheimer disease (AD) pathophysiology by binding to cell surface cellular prion protein (PrP(C)). 25148681 2014
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE For synthetic amyloid-β42, small oligomeric species showed prominent binding to PrP(C), whereas in Alzheimer's disease brains larger protein assemblies containing amyloid-β42 bound efficiently to PrP(C). 24519981 2014
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Structural and mechanistic commonalities of amyloid-β and the prion protein. 21862871 2013
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Because prion protein PrP-(23-98) was recently found to polymerize into amyloid-like and proteinase K-resistant spherical aggregates in the presence of NADPH plus copper ions, we tested to determine whether calreticulin (CRT) inhibits PrP-(23-98) aggregation in vitro. 21821925 2011
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 GeneticVariation disease BEFREE In this report, we describe the clinical, histopathological and pathological prion protein (PrP(Sc)) characteristics of two Dutch patients carrying novel adjacent stop codon mutations in the C-terminal part of PRNP, resulting in either case in hereditary prion protein amyloidoses, but with strikingly different clinicopathological phenotypes. 19911184 2010
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Amyloid-beta oligomers bind with nanomolar affinity to PrP(C), but the interaction does not require the infectious PrP(Sc) conformation. 19242475 2009
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Aggregation and amyloid fibril formation induced by chemical dimerization of recombinant prion protein in physiological-like conditions. 19710507 2009
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Association between deposition of beta-amyloid and pathological prion protein in sporadic Creutzfeldt-Jakob disease. 18349519 2008
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE FDDNP binds to PrP-amyloid in postmortem human specimens, but has not been reported in vivo in prion disease. 17636066 2007
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Hereditary prion protein amyloidoses. 12733425 2003
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 GeneticVariation disease BEFREE Gerstmann-Sträussler-Scheinker disease (GSS) is a cerebral amyloidosis associated with mutations in the prion protein (PrP) gene (PRNP). 11087738 2001
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
0.100 Biomarker disease BEFREE Prion protein amyloidosis. 8737929 1996