Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 Biomarker disease BEFREE The cell culture model of amyloid formation from serum amyloid A1 (SAA1) protein remodels crucial features of AA amyloid deposit formation in vivo. 30739503 2019
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 Biomarker disease BEFREE Human SAA and its NH<sub>2</sub>-terminal part have been studied extensively in the context of amyloidosis. 29915572 2018
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 AlteredExpression disease BEFREE Colonic amyloidosis is the result of overexpression of the serum amyloid A (SAA) protein in inflammatory bowel disease or colon cancer. 30533585 2018
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 Biomarker disease BEFREE GO induced a strong acute inflammatory response together with a pulmonary (Serum-Amyloid A, Saa3) and hepatic (Saa1) acute phase response. rGO induced less acute, but a constant and prolonged inflammation up to day 90. 28570647 2017
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease BEFREE The SAA1 α allele is strongly associated with amyloidosis in FMF patients. 27791951 2017
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 Biomarker disease BEFREE Our model is supported by the SAA cleavage in the interdomain linker to generate the 1-76 fragment deposited in reactive amyloidosis. 26918388 2016
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease BEFREE We found that the SAA1 rs12218 polymorphism was significantly more prevalent in ankylosing spondylitis patients with amyloidosis. 26300108 2015
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 Biomarker disease BEFREE The current results indicate the germ-line mutations in both genetic biomarkers (MEFV and SAA1 genes) that are related to inflammation and amyloidosis processes may play a crucial role in CRF pathogenesis due to the long-term chronic inflammation. 25394530 2015
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 Biomarker disease BEFREE SAA and SAP composition of the deposits assessed secondary type of amyloidosis. 22850426 2012
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 Biomarker disease BEFREE ApoE genotypes, systemic (C-reactive protein [CRP], fibrinogen, serum amyloid-A [SAA]) and vascular inflammatory markers (Lipoprotein-associated phospholipase A(2) [Lp-PLA(2)] and pentraxin-3 [PTX-3]) were assessed in 324 Caucasians and 208 African Americans, undergoing coronary angiography. 22632920 2012
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease BEFREE Treatment with weekly rilonacept provided marked and lasting improvement in the clinical signs and symptoms of CAPS, and normalized the levels of SAA from those associated with risk of developing amyloidosis. 18668535 2008
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease BEFREE In conclusion, the SAA1 alpha/alpha genotype is a risk factor for amyloidosis in BD. 17039260 2007
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease LHGDN In conclusion, the SAA1 alpha/alpha genotype is a risk factor for amyloidosis in BD. 17039260 2007
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease LHGDN Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis. 17968686 2007
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease BEFREE M694V homozygocity, male gender and the alpha/alpha genotype of serum amyloid A1 gene are the currently established risk factors for development of amyloidosis. 16283319 2006
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease BEFREE The SAA1 alpha/alpha genotype is a risk factor for AA type amyloidosis in Caucasoid populations and more studies are needed to investigate why the gamma/gamma genotype is associated with AA type amyloidosis in Japan. 16736418 2006
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease BEFREE In this study, we aimed to determine the effect of SAA1 -13T/C in FMF patients with and without amyloidosis. 16874691 2006
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease BEFREE To investigate the precise modality of association between SAA1 gene polymorphisms and the development of AA amyloidosis in patients with rheumatoid arthritis (RA), Japanese patients with RA (n=153), among whom 29 were histologically diagnosed as having amyloidosis, were genotyped for three single nucleotide polymorphisms (SNPs), C-13T, C2995T, and C3010T, in the SAA gene. 17039310 2006
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease BEFREE Relative transcriptional activities of SAA1 promoters polymorphic at position -13(T/C): potential association between increased transcription and amyloidosis. 16076608 2005
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease BEFREE Logistic regression analysis for amyloidosis corrected risk revealed a 1.2 times increase in M694V/M694V, a 2.4 times increase in SAA1 alpha/alpha genotypes and a 2.5 times increase when both are together. 16118480 2005
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 Biomarker disease LHGDN Clinicopathological and epidemiological analysis of amyloidosis in Turkish patients. 15972323 2005
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease BEFREE To determine if SAA concentrations and SAA1 gene polymorphisms could explain the virtual absence of amyloidosis in HIDS patients. 16011988 2005
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 AlteredExpression disease BEFREE Serum SAA levels, plasma cytokines, glomerular filtration rate and serum amyloid P scanning were monitored. 15316120 2004
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease BEFREE The results suggest a protective effect of the SAA1 beta and gamma alleles on the development of amyloidosis and show the absence of a MICA modifying effect on amyloidosis development. 15018633 2004
Entrez Id: 6288
Gene Symbol: SAA1
SAA1
0.100 GeneticVariation disease BEFREE Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population. 15170927 2004