Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | CSF Aβ levels and amyloid-PET tracer binding negatively correlated, and the concordance between the two Aβ biomarkers was 89%. | 31615545 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | All ART drugs are organic compounds that can be classified as being either weak acids or weak bases, and these physicochemical properties may be of central importance to ART drug-induced AD-like pathology because weak bases accumulate in endolysosomes, weak bases can de-acidify endolysosomes where amyloidogenesis occurs, and endolysosome de-acidification increases amyloid beta (Aβ) protein production and decreases Aβ degradation. | 31338753 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Our data demonstrate TREM2 as a microglial Aβ receptor transducing physiological and AD-related pathological effects associated with Aβ. | 29518356 | 2018 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Conversely, the α-secretase "a disintegrin and metalloproteinase" 10 (ADAM10) cleaves APP within the eventual Aβ sequence and precludes Aβ generation. | 26080426 | 2015 | ||||
|
0.080 | Biomarker | disease | BEFREE | Toxic amyloid-β40-42 (Aβ40-42) peptide cleaved from Aβ protein precursor by β- and γ secretases plays a crucial role in the etiology of Alzheimer's disease (AD). | 25037285 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | These results indicate that the dual-functional peptide S1 may have therapeutic potential for AD by both reducing Aβ generation and inhibiting Aβ cytotoxicity. | 23133641 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | A solid knowledge of the dynamics of cerebral β-amyloidosis in mouse models provides a powerful tool to monitor preclinical Aβ targeting therapeutic strategies and eases the interpretation of diagnostic amyloid imaging in humans. | 21228171 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | Alternatively, APP can be cleaved by α-secretase within the Aβ domain to release soluble APPα and preclude Aβ generation. | 21214928 | 2011 |