Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8803
Gene Symbol: SUCLA2
SUCLA2
0.080 Biomarker disease BEFREE CSF Aβ levels and amyloid-PET tracer binding negatively correlated, and the concordance between the two biomarkers was 89%. 31615545 2019
Entrez Id: 8803
Gene Symbol: SUCLA2
SUCLA2
0.080 Biomarker disease BEFREE All ART drugs are organic compounds that can be classified as being either weak acids or weak bases, and these physicochemical properties may be of central importance to ART drug-induced AD-like pathology because weak bases accumulate in endolysosomes, weak bases can de-acidify endolysosomes where amyloidogenesis occurs, and endolysosome de-acidification increases amyloid beta () protein production and decreases Aβ degradation. 31338753 2019
Entrez Id: 8803
Gene Symbol: SUCLA2
SUCLA2
0.080 Biomarker disease BEFREE Our data demonstrate TREM2 as a microglial receptor transducing physiological and AD-related pathological effects associated with . 29518356 2018
Entrez Id: 8803
Gene Symbol: SUCLA2
SUCLA2
0.080 GeneticVariation disease BEFREE Conversely, the α-secretase "a disintegrin and metalloproteinase" 10 (ADAM10) cleaves APP within the eventual sequence and precludes generation. 26080426 2015
Entrez Id: 8803
Gene Symbol: SUCLA2
SUCLA2
0.080 Biomarker disease BEFREE Toxic amyloid-β40-42 (Aβ40-42) peptide cleaved from protein precursor by β- and γ secretases plays a crucial role in the etiology of Alzheimer's disease (AD). 25037285 2014
Entrez Id: 8803
Gene Symbol: SUCLA2
SUCLA2
0.080 Biomarker disease BEFREE These results indicate that the dual-functional peptide S1 may have therapeutic potential for AD by both reducing generation and inhibiting cytotoxicity. 23133641 2012
Entrez Id: 8803
Gene Symbol: SUCLA2
SUCLA2
0.080 Biomarker disease BEFREE A solid knowledge of the dynamics of cerebral β-amyloidosis in mouse models provides a powerful tool to monitor preclinical targeting therapeutic strategies and eases the interpretation of diagnostic amyloid imaging in humans. 21228171 2011
Entrez Id: 8803
Gene Symbol: SUCLA2
SUCLA2
0.080 Biomarker disease BEFREE Alternatively, APP can be cleaved by α-secretase within the domain to release soluble APPα and preclude generation. 21214928 2011