Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3988
Gene Symbol: LIPA
LIPA
0.120 Biomarker disease HPO
Entrez Id: 50485
Gene Symbol: SMARCAL1
SMARCAL1
0.110 Biomarker disease HPO
Entrez Id: 2072
Gene Symbol: ERCC4
ERCC4
0.100 Biomarker disease HPO
Entrez Id: 2071
Gene Symbol: ERCC3
ERCC3
0.100 Biomarker disease HPO
Entrez Id: 368
Gene Symbol: ABCC6
ABCC6
0.100 Biomarker disease HPO
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.100 Biomarker disease HPO
Entrez Id: 2073
Gene Symbol: ERCC5
ERCC5
0.100 Biomarker disease HPO
Entrez Id: 7412
Gene Symbol: VCAM1
VCAM1
0.100 AlteredExpression disease BEFREE <b>Background and Aim:</b> Previously, we found that short chain fatty acids (SCFA) inhibit LPS or TNFα-induced endothelial inflammatory responses and excessive vascular cell adhesion molecule-1 (VCAM-1) expression, two important steps in the development of atherosclerosis. 29875665 2018
Entrez Id: 5444
Gene Symbol: PON1
PON1
0.100 Biomarker disease BEFREE <b>Background:</b> Paraoxonase 1 (PON1: EC 3.1.8.1) is a vital antioxidant enzyme against mainly atherosclerosis and many other diseases associated with oxidative stress. 29741961 2019
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
0.020 GeneticVariation disease BEFREE <b>Background:</b> Tumour necrosis factor like cytokine 1A (TL1A), which is a member of tumour necrosis factor alpha superfamily (TNF-α), is a novel indicator of atherosclerosis.<b>Objective:</b> Smoking is an established stimulant of TNF-α. 31646918 2019
Entrez Id: 442904
Gene Symbol: MIR335
MIR335
0.010 Biomarker disease BEFREE <b>Conclusion:</b> MiR-335-5p might serve as a negative factor for endothelial homeostasis and a potential treatment target for atherosclerosis. 30785341 2019
Entrez Id: 27163
Gene Symbol: NAAA
NAAA
0.020 Biomarker disease BEFREE <b>Conclusion:</b> Collectively, PLT-Exo overexpressing miR-25-3p attenuates ox-LDL-induced CVEC inflammation in ApoE<sup>-/-</sup> mouse models of atherosclerosis. 31632389 2019
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.100 Biomarker disease BEFREE <b>Conclusion:</b> Exosomal miR-21-3p from nicotine-treated macrophages may accelerate the development of atherosclerosis by increasing VSMC migration and proliferation through its target PTEN. 31660076 2019
Entrez Id: 54
Gene Symbol: ACP5
ACP5
0.010 AlteredExpression disease BEFREE <b>Conclusion:</b> IncRNA-H19 promoting ACP5 protein expression contributed to atherosclerosis and increased the risk of ischemic stroke. 30778327 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE <b>Conclusion:</b> RDN promoted atherosclerosis in apolipoprotein E-deficient mice infused with angiotensin II associated with upregulation of MMP-2. 28450836 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE <b>Conclusion:</b> RDN promoted atherosclerosis in apolipoprotein E-deficient mice infused with angiotensin II associated with upregulation of MMP-2. 28450836 2017
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE <b>Conclusion:</b> RDN promoted atherosclerosis in apolipoprotein E-deficient mice infused with angiotensin II associated with upregulation of MMP-2. 28450836 2017
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.100 Biomarker disease BEFREE <b>Conclusion:</b> These results indicate that CUMS exacerbates atherosclerosis is likely via HMGB1-mediated downregulation of PPARγ/LXRα-ABCA1 through TLR4. 30881312 2019
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.100 AlteredExpression disease BEFREE <b>Conclusions:</b> Our work shows that <i>in vivo</i> AAV-CRISPR/Cas9-mediated <i>Ldlr</i> gene correction can partially rescue LDLR expression and effectively ameliorate atherosclerosis phenotypes in <i>Ldlr</i> mutants, providing a potential therapeutic approach for the treatment of FH patients. 31779484 2020
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE <b>Methods</b>: Pubmed and Embase were searched to identify studies which estimated the effect of isolated alkaloids on atherosclerosis in apolipoprotein E deficient mice. 29922166 2018
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
0.030 Biomarker disease BEFREE <b>Methods</b>: We induced experimental atherosclerosis in ApoE<sup>-/-</sup>IRF1<sup>-/-</sup> mice and evaluated the effect of IRF1 on disease progression and foam cell formation. 31367250 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE <b>Methods:</b> Apolipoprotein E-deficient (Apoe<sup>-/-</sup>) mice fed a high-fat diet were given intraperitoneal injections of SAP (6 mg/kg) every other day for a total of 2 weeks to characterize atherosclerosis development. 29930724 2018
Entrez Id: 153090
Gene Symbol: DAB2IP
DAB2IP
0.050 AlteredExpression disease BEFREE <b>Objective:</b> AIP1 expression is downregulated in human atherosclerotic plaques and global deletion of AIP1 in mice exacerbates atherosclerosis in ApoE-KO mouse models. 29731721 2018
Entrez Id: 139741
Gene Symbol: ACTRT1
ACTRT1
0.050 AlteredExpression disease BEFREE <b>Objective:</b> AIP1 expression is downregulated in human atherosclerotic plaques and global deletion of AIP1 in mice exacerbates atherosclerosis in ApoE-KO mouse models. 29731721 2018
Entrez Id: 10152
Gene Symbol: ABI2
ABI2
0.050 AlteredExpression disease BEFREE <b>Objective:</b> AIP1 expression is downregulated in human atherosclerotic plaques and global deletion of AIP1 in mice exacerbates atherosclerosis in ApoE-KO mouse models. 29731721 2018