Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Matrix metallopeptidase-9 (MMP-9) was revealed to be a direct target gene of miR-133a-3p, which was upregulated in the blood and vascular plaque tissue of patients with AS. 31772631 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Toll-like receptor 4 (TLR4) and matrix metalloproteinase-9 (MMP-9) are known to play important roles in inflammatory diseases such as arteriosclerosis and plaque instability. 31001118 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Taken together, these findings highlight an important role for miR-133b/MMP-9 axis in atherosclerosis. 30926224 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Herein, patients with atherosclerosis showed higher MMP9, a promising biomarker for atherosclerosis, and lower Bmal1 and Clock expression in the plasma. 31265956 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE In atherosclerosis, P2X-purinoceptor7 (P2X7) has been related to interleukin-1β (IL-1β) and metalloproteinase 9 (MMP9). 30583923 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Altogether, these findings suggest that Lcn2 deficiency promotes lesion growth in earlier stages of the disease while it decreases MMP-9 activity and necrotic core size in advanced atherosclerosis. 29960897 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE The progression of atherosclerosis is linked to proliferation and migration of vascular smooth muscle cell via MMP-2 and MMP-9 activities. 29288721 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE We found increased levels of MMP-9 and MMP-13 in human endarterectomies with advanced atherosclerosis, together with significant amounts of extracellular matrix (ECM) metalloproteinase inducer EMMPRIN. 30347750 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Dose-Effect of Irbesartan on Cyclooxygenase-2 and Matrix Metalloproteinase-9 Expression in Rabbit Atherosclerosis. 29420356 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Additionally, ginkgetin reduced the mRNA and protein expression of MMP-2 and MMP-9 in thoracic aortas of rats with atherosclerosis. 29579712 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE P2X7R may serve a crucial role in the development of atherosclerosis; therefore, the present study aimed to determine whether P2X7R regulated the expression of EMMPRIN and MMP‑9 in phorbol 12‑myristate 13‑acetate (PMA)‑induced macrophages. 30015874 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE In the present study, we investigated the expression of matrix metalloproteinase-9 (MMP-9), which is one of key mediators of atherosclerosis progression, in oxLDL-treated human umbilical vein endothelial cells (HUVEC)-C cells. 29104665 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Matrix metalloproteinase-9 (MMP-9) is involved in the stability of the extracellular matrix (ECM) and atherosclerosis plaque. 27237101 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Ghrelin significantly decreased the plaque content of macrophages, matrix metalloproteinase (MMP)-2, and MMP-9, in a rabbit model of atherosclerosis. 28189525 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Previously, Matrix metalloproteinase-9 (MMP-9), monocyte chemotactic protein-1 (MCP-1) and toll-like receptor 4 (TLR4) were confirmed to play an important role in atherosclerosis and plaque instability. 28957799 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Based on the studies performed so far, it is assumed that IL-17 contributes to development of atherosclerosis by means of: stimulation of production of proinflammatory compounds; induction of apoptosis of endothelial cells and heart muscle cells; stimulation of von Willebrand factor production; and induction of the matrix metalloproteinase-9 (atherosclerotic plaque rupture). 27696392 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE NGAL modulates the enzymatic activity of matrix metalloproteinase-9 (MMP-9), which is an important mediator of plaque instability in atherosclerosis. 28672731 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Human sLZIP promotes atherosclerosis via MMP-9 transcription and vascular smooth muscle cell migration. 25077563 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Serum levels and polymorphisms of matrix metalloproteinases (MMPs) in carotid artery atherosclerosis: higher MMP-9 levels are associated with plaque vulnerability. 24369095 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Matrix metalloproteinase-9 (MMP-9) plays an important role in inflammation and matrix degradation involved in atherosclerosis and plaque rupture. 23819814 2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 GeneticVariation disease BEFREE The present study aims to ascertain the polymorphic variants of the MMP-9 gene promoter and its serum levels, which contribute to interindividual differences in susceptibility to atherosclerosis. 22809399 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Matrix metalloproteinase 9 (MMP-9) plays a pivotal role in early atherosclerosis, vascular remodeling, and development of arterial plaque rupture. 21733941 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Hypertension-induced atherosclerosis was associated with significantly increased levels of MMP-9 mRNA, which may enhance both the deposition of types I and III collagen and atherosclerotic plaque formation. 22906271 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 AlteredExpression disease BEFREE Cholestin reduces TNF-α-stimulated MMP-2 and MMP-9 expression as well as downregulating NF-κB activation and intracellular ROS formation in HASMCs, supporting the notion that the natural compound Cholestin may have potential application in clinical atherosclerosis disease. 22060290 2011
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.300 Biomarker disease BEFREE Therefore, in the present study we tried to explore the role of CRP as a possible mediator of atherosclerosis by determining its effect on PPAR-gamma and its effector genes, i.e., liver X receptor-alpha (LXR-alpha) and matrix metalloproteinase-9 (MMP-9) in THP-1 cells. 20682172 2010