Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE Several pathogenic mechanisms such as inflammation-related endothelial dysfunction, mineral metabolism disorders, activation of the renin-angiotensin system, reduction of nitric oxide, lipid disorders, and the fibroblast growth factor 23-klotho axis are involved in the pathogenesis of atherosclerosis and arteriosclerosis, including VC. 31801144 2020
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 GeneticVariation disease BEFREE In predialysis stage 3-5 diabetic and nondiabetic CKD patients, CAVI levels and its relation to atherosclerosis-associated risk factors including monocyte-chemoattractant protein-1 (MCP-1), sclerostin, fibroblast growth factor-23 (FGF-23), Klotho, and 25-OH vitamin D were determined. 31773386 2020
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 GeneticVariation disease BEFREE The aim of this study is to determine the role of 11 single-nucleotide polymorphisms (SNPs) of the Klotho gene on the rate of atherosclerosis progression in CKD. 30010839 2019
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE Most notably, Klotho deficiency is associated with a phenotype comprising organ manifestations accompanying aging including atherosclerosis and cognitive impairment. 31055648 2019
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE Circulating α-Klotho Levels in Hemodialysis Patients and Their Relationship to Atherosclerosis. 30064142 2018
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE Most notably, Klotho deficiency is associated with a phenotype comprising organ manifestations accompanying aging including atherosclerosis and cognitive impairment. 29274997 2018
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE Finally, we demonstrate that Klotho protein treatment can protect against IS-induced thrombosis and atherosclerosis in <i>apoE</i><sup>-/-</sup> mice. 28264799 2017
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 AlteredExpression disease BEFREE Growing evidence suggests that an increase in KL expression may be beneficial for age-related diseases such as arteriosclerosis and diabetes. 28657902 2017
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE Klotho, an anti-aging protein, has been reported to protect against atherosclerosis and ameliorate endothelial dysfunction in vivo. 28407763 2017
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE Our study indicates an inverse interrelationship between inflammation and Klotho in atherosclerosis. 28963437 2017
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE Klotho is a hormone secreted into human cerebrospinal fluid (CSF), plasma and urine that promotes longevity and influences the onset of several premature senescent phenotypes in mice and humans, including atherosclerosis, cardiovascular disease, stroke and osteoporosis. 27576165 2016
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE The role in atherosclerosis and cardiovascular disease of klotho, an aging process-related gene, has been highlighted. 23993164 2013
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE Klotho, a gene related to aging, has been reported to play a role in atherosclerosis and endothelial dysfunction. 23147162 2012
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE Klotho gene might be a candidate gene of atherosclerosis in some populations but not in Iranian population. 22045427 2011
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 GeneticVariation disease BEFREE Previous studies suggest that klotho gene polymorphisms may be associated with atherosclerosis, but did not assess the relationship between klotho gene polymorphisms and atherosclerosis parameters such as carotid artery intima-media thickness (IMT). 20345435 2010
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 GeneticVariation disease BEFREE Mice with defects in the Klotho gene exhibit multiple aging phenotypes including arteriosclerosis. 20005218 2010
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE On the other hand, klotho is a putative antiaging gene identified in 1997 when a particular mouse strain, created by random insertion mutagenesis, was found to be short-lived and displayed premature atherosclerosis, osteopenia, skin atrophy, pulmonary emphysema, hyperphosphatemia, hypercalcemia, and high serum calcitriol levels. 19121771 2009
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 GeneticVariation disease BEFREE Experimental studies have demonstrated KLOTHO gene polymorphism might be associated with vascular atherosclerosis and calcification. 19246844 2009
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE Klotho-disrupted mice exhibit atherosclerosis and endothelial dysfunction, which led us to investigate the effect of the Klotho protein on vascular inflammation, particularly adhesion molecule expression. 19367378 2009
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 GeneticVariation disease BEFREE Recent studies have shown that a klotho gene mutation is related to endothelial dysfunction, thrombosis, and arteriosclerosis, which are regarded as causes of vascular access dysfunction. 19119257 2008
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes, including atherosclerosis. 16579981 2006
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE These results infer the possibility of the KLOTHO gene being a candidate gene of atherosclerosis in humans, and further research on this topic needs to be done. 16979405 2006
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease BEFREE Klotho-deficient mice display extensive arteriosclerosis when fed a normal diet, suggesting a potent genetic predisposition. 12669274 2003
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 AlteredExpression disease BEFREE A defect of kl gene expression in the mouse results in a syndrome resembling human aging, such as arteriosclerosis, skin atrophy, osteoporosis, and pulmonary emphysema. 11016890 2000
Entrez Id: 9365
Gene Symbol: KL
KL
0.400 Biomarker disease CTD_human A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. 9363890 1997