Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE The aim of this study was to identify several specific reliable metabolites for predicting the response of RA patients to TNF-α inhibitors (TNFi) and abatacept (ABT), using capillary electrophoresis-time-of-flight mass spectrometry (CE-TOFMS). 31143951 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE The TNF-transgenic (TNF-Tg) murine model of RA develops both inflammatory arthritis and an ILD that mimics a cellular nonspecific interstitial pneumonia pattern dominated by an interstitial accumulation of inflammatory cells with minimal-to-absent fibrosis. 31659014 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE In this study, we investigated the association between rheumatoid factor (RF) and anti-citrullinated protein autoantibody (ACPA) status and the discontinuation of tumor necrosis factor inhibitors (TNFi) therapy due to insufficient response in bio-naïve rheumatoid arthritis (RA) patients. 31179526 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Tumor necrosis factor alpha (TNFα) and its type 1 receptor (TNFR1) are implicated in several autoimmune diseases, including rheumatoid arthritis, and are associated with complications at the cardiovascular level. 30897335 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE These findings showed that exercise and anti-TNF had differential effects on CVD risk in RA, and should be combined for optimal CVD risk reduction. 30421104 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Restored and Enhanced Memory T Cell Immunity in Rheumatoid Arthritis After TNFα Blocker Treatment. 31105703 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE Patients with rheumatoid arthritis (RA) can be successfully treated with tumor necrosis factor (TNF) inhibitors, including the monoclonal antibody adalimumab. 30700574 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE We used a TNF-α reliant mouse model of RA. 30778120 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Accumulating evidence shows the safety of Tumor Necrosis Factor inhibitors in pregnant RA patients and patients with a wish to conceive. 31779849 2019
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE The recent meta-analysis of GWAS has expanded the total number of RA-associated loci to more than 100, out of which approximately ∼97% (98 variants) loci are located in non-coding regions, and the other ∼3% (3 variants) are in three different non-HLA genes, i.e., TYK2 (Prp1104Ala), IL6R (Asp358Ala), and PTPN22 (Trp620Arg). 30899276 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE The objective of this study was to identify new genetic variation associated with the clinical response to anti-TNF therapy in RA. 31312201 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE To examine the influence of smoking on biologics treatment against different therapeutic targets, such as TNFα, IL-6, and T cell, in rheumatoid arthritis (RA) and elucidate the underlying molecular mechanism. 30591403 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Evidence supports the clinical benefits of early aggressive biologic treatment in patients with rheumatoid arthritis (RA) who have an inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), but the cost-effectiveness of early intervention with originator biologics such as tumor necrosis factor inhibitors (TNFis) or their biosimilars has not been well studied. 31148057 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Hypothesizing that FLSs stimulated with 2GF + TNF would accumulate <i>in vivo</i> in RA, we determined the therapeutic effects of TNF and CDK4/6 inhibitors. 30828336 2019
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease GWASCAT Studying the effects of haplotype partitioning methods on the RA-associated genomic results from the North American Rheumatoid Arthritis Consortium (NARAC) dataset. 30891314 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE The effect of non-TNF-targeted biologics on vascular dysfunction in rheumatoid arthritis: A systematic literature review. 30844558 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Pharmacodynamic biomarkers and differential effects of TNF- and GM-CSF-targeting biologics in rheumatoid arthritis. 30358109 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE To assess the hypothesis if tocilizumab (TCZ) is effective on disease activity, and also its effect in fatigue and other clinical and psychological disease-related factors in patients with rheumatoid arthritis (RA) treated with TCZ.A 24-week, multicenter, prospective, observational study in patients with moderate to severe RA receiving TCZ after failure or intolerance to disease-modifying antirheumatic drugs or tumor necrosis factor-alpha was conducted.Of the 122 patients included, 85 were evaluable for effectiveness (85% female, 51.9 ± 12.5 years, disease duration 8.7 ± 7.4 years). 31261500 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE We discovered 280 TNF-inducible arthritogenic genes which are transiently expressed and subsequently repressed in macrophages, but in RA, FLS are expressed with prolonged kinetics that parallel the unremitting kinetics of RA synovitis. 31097419 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Of the disease-modifying antirheumatic drugs (DMARDs) used for RA treatment, methotrexate, triple combination oral therapy (methotrexate, sulfasalazine, and hydroxychloroquine), tumor necrosis factor inhibitor biologicals, and abatacept have the strongest data in favor of the reduction of cardiovascular events in patients with RA. 30953327 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Artesunate significantly inhibited the migration and invasion of RA-FLS in a dose-dependent manner with or without TNF-α stimulation. 31234900 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE This study was aimed to investigate the association of the single nucleotide polymorphism of tumor necrosis factor receptor associated factor 6 (TRAF6), rs540386, with low bone mineral density (BMD) among patients with rheumatoid arthritis (RA). 30506403 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 PosttranslationalModification disease BEFREE Western blot assays were employed to examine c-Jun N-terminal kinase (JNK) expression and phosphorylation in TNF-α-induced HFLS-RA. 31258709 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE Our results do not support a causal relationship between TNF expression, serum TNF-α levels, and RA on AD risk. 31587925 2019