Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease GWASCAT Genetic influences on susceptibility to rheumatoid arthritis in African-Americans. 30423114 2019
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE This finding indicates that the inherited altered genetic constitution at IL2RA may predispose to a less destructive course of RA. 31134763 2019
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE In contrast, both antibodies induced early and sustained suppression of RA disease markers, including interleukin (IL)-6, C-reactive protein, IL2RA, and matrix metalloproteinase 1, in DMARD-IR patients. 30358109 2019
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE RESULTS Compared with the healthy controls, the proportions of CD3+CD4+ T cells and CD3+CD4+CD25+CD127low T cells in the peripheral blood were significantly higher in RA patients. 30106887 2018
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 AlteredExpression disease BEFREE It was observed that in peripheral blood, CD4+CD25-FOXP3+/CD4+ levels were reduced in the RA group (P<0.001), and sPD‑1 levels were markedly higher (P<0.001), compared with the HC group. 27909722 2017
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE Phenotypic, Functional, and Gene Expression Profiling of Peripheral CD45RA+ and CD45RO+ CD4+CD25+CD127(low) Treg Cells in Patients With Chronic Rheumatoid Arthritis. 26314565 2016
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE Targeted exon sequencing identified rare variants in IL2RA and IL2RB associated with rheumatoid arthritis. 27224741 2016
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE This underlines the relevance of IL2RA for RA. 26350950 2015
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease GWASCAT Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342 2014
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342 2014
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease GWASDB Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. 24449572 2014
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE In this study, we demonstrated that the frequencies of CD3(+) CD4(+) IL-17(+) Th17 cells were significantly higher, and CD4(+) CD25(+) FOXP3(+) Treg cells significantly lower in peripheral blood mononuclear cells from RA patients. 25164131 2014
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease GWASCAT Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. 24449572 2014
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE In this study, we have used a microarray approach to comprehensively analyze miRNA expression signatures of both naive Tregs (CD4+CD45RO-CD25++) and memory Tregs (CD4+CD45RO+CD25+++), as well as conventional naive (CD4+CD45RO-CD25-) and memory (CD4+CD45RO+CD25-) T cells (Tconvs) derived from peripheral blood of RA patients and matched healthy controls. 24401767 2014
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE We observed an accumulation of rare nonsynonymous variants exclusive to RA cases in IL2RA and IL2RB (burden test: p = 0.007 and p = 0.018, respectively). 23261300 2013
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE The present genetic and serologic data suggest that inherited altered genetic constitution at the IL2RA locus may predispose to a less destructive course of RA. 23529819 2013
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease CTD_human High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 AlteredExpression disease BEFREE DNA microarray analysis of peripheral blood lymphocytes showed significant increase of interleukin (IL)-2 receptor α-chain (CD25) gene expression, a regulatory T cell (Treg) surface marker in severe RA patients. 21670968 2012
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE However, replicated associations of HLA-DRB1, PTPN22 (which confer ∼50% of the heritable risk to RA) and IL2RA suggest that cross-ethnicity fine mapping of such loci is apposite for identification of causal variants. 22355377 2012
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE The present study provides the first evidence of increased CD25(-)FOXP3(+) cells in RA patients, which were associated with disease activity and with GC treatment in carriers of the high IL-10 genotype, suggesting that this population plays a role in the clinical response to prednisone in RA. 22447883 2012
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) are involved in several autoimmune diseases, including rheumatoid arthritis. 21346237 2011
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE TRAIL is associated with impaired regulation of CD4+CD25- T cells by regulatory T cells in patients with rheumatoid arthritis. 21732015 2011
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE Previous studies suggested the association of interleukin-2 (IL2) gene polymorphisms and its alpha- and beta-chain receptor (IL2RA and IL2RB) variants with different autoimmune diseases such as T1D, celiac disease, multiple sclerosis, and rheumatoid arthritis. 21875375 2011
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease CTD_human We observed an increased expression of full-length FoxP3 mRNA in RA patients when compared to healthy controls, as well as an increase in CD25 mRNA expression, but no corresponding increase in CTLA-4 mRNA expression. 20476861 2010