Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 Biomarker disease BEFREE Anakinra, an interleukin-1 receptor antagonist and tocilizumab, an interleukin-6 receptor blocker, are used for the treatment of rheumatoid arthritis. 30859382 2019
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 GeneticVariation disease GWASCAT Genetic influences on susceptibility to rheumatoid arthritis in African-Americans. 30423114 2019
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 Biomarker disease BEFREE Multiple studies have shown seemingly unfavorable changes in lipid profiles associated with interleukin-6 receptor (IL-6R) antagonists and some other therapies for rheumatoid arthritis. 30175897 2019
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 Biomarker disease BEFREE She had also been treated for rheumatoid arthritis with prednisolone, methotrexate, and tocilizumab (interleukin-6 receptor inhibitor). 30852105 2019
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 GeneticVariation disease BEFREE The recent meta-analysis of GWAS has expanded the total number of RA-associated loci to more than 100, out of which approximately ∼97% (98 variants) loci are located in non-coding regions, and the other ∼3% (3 variants) are in three different non-HLA genes, i.e., TYK2 (Prp1104Ala), IL6R (Asp358Ala), and PTPN22 (Trp620Arg). 30899276 2019
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 Biomarker disease BEFREE Tocilizumab (TCZ), a humanized monoclonal antibody against the interleukin-6 receptor, has been proven to be a safe and effective treatment for rheumatoid arthritis (RA). 31801637 2019
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 Biomarker disease BEFREE To investigate the efficacy and safety of tocilizumab (TCZ) humanized anti-interleukin-6 receptor monoclonal antibody, in Korean patients with active rheumatoid arthritis (RA) refractory to conventional disease modifying anti-rheumatic drugs (DMARDs) including methotrexate (MTX). 29334721 2019
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 Biomarker disease BEFREE Tocilizumab, a humanized monoclonal antibody targeting the interleukin-6 receptor, has been used with great efficacy and safety in rheumatoid arthritis and systemic-onset juvenile idiopathic arthritis. 29570475 2018
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 GeneticVariation disease BEFREE To observe patients with rheumatoid arthritis (RA) treated with the interleukin-6 receptor-alpha inhibitor tocilizumab (TCZ) in routine clinical practice. 28516886 2018
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 GeneticVariation disease BEFREE Influence of IL6R gene polymorphisms in the effectiveness to treatment with tocilizumab in rheumatoid arthritis. 27958380 2018
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 Biomarker disease BEFREE To describe the effectiveness and safety of tocilizumab (TCZ), an interleukin-6 receptor inhibitor, in a cohort of patients with rheumatoid arthritis (RA) recruited in clinical practice. 28516890 2018
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 Biomarker disease BEFREE The IL-6-soluble IL-6Rα-gp130 complex is hyperactive in RA and OA. 29755657 2018
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 Biomarker disease BEFREE Tocilizumab (humanized monoclonal antibody against the interleukin-6 receptor) was introduced on the basis of its effectiveness in RA without concomitant MTX and the ability to overcome the profibrotic effects of interleukin (IL)-6. 27733490 2017
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 Biomarker disease BEFREE Tocilizumab is a humanized anti-interleukin-6 receptor antibody for treating rheumatoid arthritis. 27599663 2017
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 Biomarker disease BEFREE Tumour necrosis factor inhibitors and interleukin 6 receptor blocker licensed for the treatment of RA decrease inflammation and could thus improve cardiovascular risk, but their effects on body composition and metabolic profile need to be clarified. 28316139 2017
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 Biomarker disease BEFREE This study evaluated the pharmacokinetic profile of simvastatin (a CYP3A4 substrate) before and 1 week after a single dose of sarilumab (a human monoclonal antibody [mAb] blocking the IL-6Rα) in patients with RA, to assess potential interaction. 27722854 2017
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 GeneticVariation disease GWASCAT High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. 24532676 2015
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 GeneticVariation disease BEFREE Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis. 26336855 2015
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 AlteredExpression disease BEFREE We studied dipeptidyl peptidase IV (DPP-IV, CD26) expression in different T helper cells and serum soluble DPP-IV/sCD26 levels in rheumatoid arthritis (RA) patients, correlated these with disease activity score (DAS), and examined how they were affected by different therapies, conventional or biological (anti-TNF, anti-CD20 and anti-IL6R or Ig-CTLA4). 26177310 2015
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 AlteredExpression disease BEFREE Gene expression studies showed that blockade of the interleukin-6 receptor (IL-6R) gene (IL6R) using TCZ induced a significant decrease in the expression of numerous chemokine and T cell activation genes in the RA synovium. 24449571 2014
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 GeneticVariation disease GWASCAT Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342 2014
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 GeneticVariation disease BEFREE These data suggest that genetic variation in IL6R may aid in predicting TCZ therapy outcome in RA patients. 24978393 2014
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 GeneticVariation disease GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342 2014
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 GeneticVariation disease BEFREE Although a common, non-synonymous variant in the IL-6 receptor gene (IL6R rs2228145" genes_norm="3570">Asp358Ala; rs2228145 A>C) is associated with the risk of several common diseases, with the 358Ala allele conferring protection from coronary heart disease (CHD), rheumatoid arthritis (RA), atrial fibrillation (AF), abdominal aortic aneurysm (AAA), and increased susceptibility to asthma, the variant's effect on IL-6 signaling is not known. 23593036 2013
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
0.500 GeneticVariation disease GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012