Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE Abatacept is a biologic agent selectively targeting the T-cell costimulatory signal delivered through the CD80/86-CD28 pathway and was approved in December 2005 by the US Food and Drug Administration and in May 2007 by European Medicines Agency for the treatment of patients with rheumatoid arthritis in combination with methotrexate. 29922065 2018
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE Indeed, pharmacological blockade of CD28 costimulation using CTLA-4Ig (abatacept), approved for amelioration of RA, renders T cells dormant (anergic). 29500936 2018
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE In the present study, we co-cultured RA-FLS with or without anti-CD3/CD28-stimulated PBMC. 28833034 2017
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians. 27125674 2016
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 GeneticVariation disease BEFREE A Combination of CD28 (rs1980422) and IRF5 (rs10488631) Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study. 27092776 2016
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE Natural Killer cells and CD28 null T-cells are suspected as role players in RA pathogenesis. 26658904 2015
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE The expansion of CD4(+)CD28(null) cells in RA patients was associated with TNFA genotype, even at diagnosis, and linked to markers of aggressive disease in patient carriers of the minor allele. 25510954 2015
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE Killer cell immunoglobulin-like receptors (KIR) expressed on surface of natural killer cells and CD28 null T-cells which are present in synovial membrane of RA. 24912006 2014
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE Forty-four patients with RA, displaying a distinct CD4(+) CD28(null) T cell population in blood, were recruited for this study; the methylation status of the IFNG locus was examined in isolated T cell subsets, and intracellular cytokine production (IFN-γ, TNF, IL-17) and chemokine receptor expression (CXCR3, CCR6 and CCR7) were assessed by flow cytometry on T cells from the two compartments. 24313359 2014
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE In addition, The percentage of peripheral CD4+DR3+T cells of RA was significantly higher than that of healthy controls (HC), and this increased percentage of CD4+DR3+T cells was obviously up-regulated when stimulated with anti-CD3 and anti-CD28 antibody in RA patients. 24832108 2014
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE Cytokine-producing CD4+ T cells included the CD45RO+ and CD45RO- and the CD28+ and CD28- subsets in RA patients. 22594821 2012
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease CTD_human High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 AlteredExpression disease BEFREE The Ca(2+) influx was lower in anti-CD3 + anti-CD28-activated MNC from RA patients than healthy volunteers and suppressed by nifedipine. 22385242 2012
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE PBMCs of healthy donors and RA patients were stimulated with CD3 and CD28 monoclonal antibodies to produce high levels of IL-17. 21691744 2012
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 GeneticVariation disease GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE The CD28 gene is similarly down-regulated in CD4(+) lymphocytes from both healthy elderly people and patients with rheumatoid arthritis (RA) because of impaired protein-binding activity of the 'α' sequence in its promoter region. 20738421 2011
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 GeneticVariation disease BEFREE The gene includes the CD28 IVS3 +17T/C polymorphism that could be associated with susceptibility to RA whereas the soluble concentrations of CD28 (sCD28) could be related to clinical activity. 21508506 2011
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 GeneticVariation disease BEFREE Our results suggest that CD28 and ICOS genes may be associated with a risk of RA in Koreans. 20113255 2010
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE Altogether these results demonstrate a pattern of additive effects in NKR-mediated functional modulation of CD4(+)CD28(-) T cells in RA. 19904767 2010
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease CTD_human Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. 20453842 2010
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease CTD_human Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. 19898481 2009
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE A senescent CD4(+)CD28(-) T cell subset develops with aging and in chronic inflammatory diseases like rheumatoid arthritis, and is implicated in plaque rupture and myocardial infarctions. 19394279 2009
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 AlteredExpression disease BEFREE Fibroblast-like synoviocytes (FLS) and T cells can activate each other in vitro, and in vivo interactions between these cells may be important in rheumatoid arthritis (RA), yet FLS lack significant expression of CD28 ligands. 18292521 2008
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE Rheumatoid arthritis (RA) is characterized by premature immune aging with accumulation of degenerate T cells deficient for CD28. 17675524 2007
Entrez Id: 940
Gene Symbol: CD28
CD28
0.500 Biomarker disease BEFREE The latter has gained momentum along with the reported expansion of peripheral CD4(+)CD28(-)NKG2D(+) T cells in rheumatoid arthritis (RA). 17565371 2007