Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE The TNF-α level in AS was significantly lower than that in RA (p = 0.016). 31830775 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE The feasibility of specific immuno-PET imaging of human TNFα was assessed in a transgenic mouse model of RA that expresses human TNFα. 31065895 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE The present study was performed to investigate the possible effects of BBB dysfunction and tumor necrosis factor (TNF) blocker therapy on BBB function, which may cause CNS damage in patients with RA. 29288410 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE We performed a systematic review and meta-analysis to evaluate the comparative effects of tumor necrosis factor-α inhibitors (TNFi), non-TNFi biologic and conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) on cardiovascular risk in rheumatoid arthritis (RA). 30875456 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE Neutrophils and peripheral blood mononuclear cells (PBMCs) were isolated from three patients diagnosed with RA and treated with various concentrations of IGU, methotrexate (MTX), or dexamethasone (DXM) or without any drugs as a control for 8 h. The levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-8 in culture supernatants were tested by ELISA. 31758423 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Biologicals, e.g.TNF inhibitors, have improved dramatically the efficacy of medical interventions in autoimmune diseases, such as in rheumatoid arthritis (RA). 30900933 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE We sought to mechanistically investigate the relationship between certolizumab concentrations, ADAs, and the effective TNF neutralising capacity in sera of rheumatoid arthritis (RA) patients. 31498069 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE We aimed to evaluate the comparative risk of hospitalized infection among patients with rheumatoid arthritis (RA) who initiated abatacept versus a tumor necrosis factor inhibitor (TNFi). 30570833 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE To compare the risk for major adverse cardiovascular events (MACE) in RA patients treated with tocilizumab versus the tumor necrosis factor inhibitor etanercept. 31469238 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE A Budget Impact and Cost Per Additional Responder Analysis for Baricitinib for the Treatment of Moderate-to-Severe Rheumatoid Arthritis in Patients with an Inadequate Response to Tumor Necrosis Factor Inhibitors in the USA. 31452079 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Effect of TNF inhibitors on bone mineral density in rheumatoid arthritis patients receiving bisphosphonate: a retrospective cohort study. 31414225 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE Here, we report that protein phosphatase magnesium-dependent 1A (PPM1A) levels were increased in RA synovial fluid compared with osteoarthritis (OA) synovial fluid and positively correlated with TNF levels. 31791585 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Tumour necrosis factor-α (TNF-α) inhibitors are increasingly being used as immunomodulators to manage inflammatory conditions such as rheumatoid arthritis and Crohn's disease. 31645276 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE However, evidence is inconsistent as to whether RA patients with anti-TNF are associated with an increased risk of non-melanoma skin cancer (NMSC) compared with those without anti-TNF. 31823140 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Correction to: A Budget Impact and Cost Per Additional Responder Analysis for Baricitinib for the Treatment of Moderate-to-Severe Rheumatoid Arthritis in Patients with an Inadequate Response to Tumor Necrosis Factor Inhibitors in the USA. 31712980 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Key Message:Successful TNF inhibitor cessation is achievable in two-third of RA patients after achieving sustained remission.Female gender and smoking may predispose to flare after TNF inhibitor cessation.Early intervention with TNF inhibitor may contribute to successful TNF inhibitor cessation. 31814481 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE In conclusion, these results have demonstrated the therapeutic potential of retinoic acid on RA FLS provided TNF could be counterbalanced, either with high ATRA doses or with TNF inhibitors. 31801802 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Comparative effectiveness of TNF inhibitors and tocilizumab with and without conventional synthetic disease-modifying antirheumatic drugs in a pan-European observational cohort of bio-naïve patients with rheumatoid arthritis. 31280937 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Systematic review of economic evaluations of cycling versus swapping in patients with rheumatoid arthritis after failure to tumor necrosis factor inhibitors. 30801951 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Real-world treatment persistence of non-tumor necrosis factor inhibitors versus tumor necrosis factor inhibitors among patients with rheumatoid arthritis in South Korea. 31670976 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE This study aimed to evaluate the combinatorial effect of TNF and IL-6 inhibitors on the differentiation and activation of Th17 cells and osteoclasts in the context of RA, and to identify the RA-related mechanisms through IL-6 signaling. 31818460 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Furthermore, both TNF-α and IL-6 are important pathogenic factors related to immune-mediated bone diseases including rheumatoid arthritis and postmenopausal osteoporosis. 31433756 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Presence of anti-cyclic citrullinated peptide antibodies is associated with better treatment response to abatacept but not to TNF inhibitors in patients with rheumatoid arthritis: a meta-analysis. 31770089 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE TCZ-SC, alone or with a csDMARD, yielded rapid and sustained efficacy in DMARD/anti-TNFα-IR RA patients, with acceptable toxicity.Home administration seems feasible. 30421069 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE To evaluate the efficacy and safety of interleukin 17 (IL-17) inhibitors in two rheumatoid arthritis (RA) populations: biologic-naïve or tumor necrosis factor inhibitor inadequate responders (TNF-IR). 31165341 2019