Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population. 28500376 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE PTPN22 -1123G>C polymorphism and anti-cyclic citrullinated protein antibodies in rheumatoid arthritis. 28291534 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE A novel scoring system based on common laboratory tests predicts the efficacy of TNF-inhibitor and IL-6 targeted therapy in patients with rheumatoid arthritis: a retrospective, multicenter observational study. 28800780 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE Expression of Dicer in rheumatoid arthritis is associated with disease activity and balances the production of TNF‑α. 28627619 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE The reduction of synovial tissue macrophages is a reliable biomarker for clinical improvement in patients with rheumatoid arthritis (RA), and macrophages are reduced in synovial tissue shortly after initiation of TNF inhibitors. 29150565 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Tumor necrosis factor receptor-associated factor (TRAF) 6 inhibition mitigates the pro-inflammatory roles and proliferation of rheumatoid arthritis fibroblast-like synoviocytes. 28506571 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE NLRP1, PTPN22 and PADI4 gene polymorphisms and rheumatoid arthritis in ACPA-positive Singaporean Chinese. 28653215 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Tumor necrosis factor (TNF)-α is responsible for expressions of several clock genes and affects joint symptoms of rheumatoid arthritis (RA) with diurnal fluctuation. 29217191 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Paeonol protects against TNF-α-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes by upregulating FOXO3 through inhibition of miR-155 expression. 28401267 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE The treatment of rheumatoid arthritis (RA) with tumor necrosis factor-alpha (TNF-α) inhibitors could lead to adverse effects. 28113136 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Genomic Responses of Mouse Synovial Fibroblasts During Tumor Necrosis Factor-Driven Arthritogenesis Greatly Mimic Those in Human Rheumatoid Arthritis. 28409894 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE Resistin Gene Expression is Downregulated in CD4(+) T Helper Lymphocytes and CD14(+) Monocytes in Rheumatoid Arthritis Responding to TNF-α Inhibition. 27434862 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in CD8<sup>+</sup> T Cytotoxic Lymphocytes and CD19<sup>+</sup> B Lymphocytes in Rheumatoid Arthritis Responding to TNF-α Inhibition. 28426141 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Neutrophil biomarkers predict response to therapy with tumor necrosis factor inhibitors in rheumatoid arthritis. 27733572 2017
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease BEFREE PTPN22 polymorphisms, but not R620W, were associated with the genetic susceptibility of systemic lupus erythematosus and rheumatoid arthritis in a Chinese Han population. 27166176 2017
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.700 GeneticVariation disease GWASCAT A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus. 27193031 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE Brief Report: The Role of Rare Protein-Coding Variants in Anti-Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis. 27788309 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE TNFR1 and TNFR2 differentially mediate TNF-α-induced inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes. 28150360 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 AlteredExpression disease BEFREE Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytes. 28708839 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 GeneticVariation disease BEFREE A host of studies investigated the associations between tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene rs2230926 and rs5029937 polymorphisms and rheumatoid arthritis (RA) susceptibility, but with conflicting findings. 28888761 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE TNF-α plays a key role in the development of rheumatoid arthritis (RA) and inflammatory bone loss. 28771604 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE These results indicate that CD94 and NKG2A polymorphisms may contribute to genetic susceptibility to RA or affect the response to anti-TNF therapy in patients of Caucasian origin. 26453102 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE We have shown, in vitro, that celastrol inhibits both IL-1β and TNF, which play an important role in RA, and, in vivo, that celastrol has significant anti-inflammatory properties. 26658436 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE We previously described that sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis varied in rheumatoid arthritis fibroblasts-like synoviocytes (RAFLS) from one patient to another and was correlated with disease severity. 26247836 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.700 Biomarker disease BEFREE A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis. 25896534 2016