Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Identification of a new locus at 16q12 associated with time to asthma onset. 27130862 2016
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). 19198610 2009
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 AlteredExpression disease BEFREE ST2L expression was increased in severe asthma (P = .02) and associated with multiple indicators of TH2-like inflammation, including blood eosinophils (P = .001), exhaled nitric oxide (P = .003), and epithelial CLCA1 (P < .0001) and eotaxin-3 (P = .001) mRNA expression. 25091434 2015
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 AlteredExpression disease BEFREE We assessed in the prospective birth cohort Prevention and Incidence of Asthma and Mite Allergy (PIAMA) whether IL1RL1 SNPs associate with levels of its soluble transcript IL1RL1 (IL1RL1-a) in serum, blood eosinophil counts, and asthma prevalence from birth to age 8 years, and whether IL1RL1-a serum levels associate with blood eosinophil counts. 21281963 2011
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Interestingly, the IL1RL1, HLA, IL13 and C11orf30 regions are overlapping susceptibility loci among atopic dermatitis and asthma or allergic rhinitis. 23439055 2013
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Two-gene models implicating functional variants in the IL10 and VDR genes as well as in the IL10 and IL1RL1 genes were associated with asthma (p < 0.0002). 19852851 2009
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease CTD_human Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma. 24241537 2014
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 AlteredExpression disease BEFREE Plasma and sputum IL-33, soluble ST2 (sST2) levels, and ST2L expression on eosinophils were measured in 10 healthy controls and 10 allergic asthmatics. 29694974 2018
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE The critical function of IL-33/ST2 signaling in allergic inflammation is illustrated by the fact that IL33 and IL1RL1 are among the most highly replicated susceptibility loci for asthma. 29247993 2018
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Polymorphisms in the IL33 and IL1RL1 can act as protective or risk factors for asthma and/or allergy in humans. 28266165 2017
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease CTD_human Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. 21804549 2011
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE IL-33 is likely to play a critical role in asthma because the IL33 and ST2/IL1RL1 genes have been reproducibly identified as major susceptibility loci in large-scale genome-wide association studies. 25313073 2014
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE We evidenced a new locus in the 16q12 region (near cylindromatosis turban tumor syndrome gene [CYLD]) and confirmed 4 asthma risk regions: 2q12 (IL-1 receptor-like 1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA]). 27130862 2016
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASDB Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. 23028483 2012
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503 2010
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE This review describes the mechanisms through which genetic variation at the IL33 and IL1RL1 loci translates into increased susceptibility for asthma. 23380221 2013
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. 30552067 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. 31619474 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease LHGDN Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. 18774397 2008
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. 21804549 2011
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE Multimarker analysis identified TGFB1, IL1RL1, the gene encoding IL-18 receptor 1 (IL18R1), and DPP10 as the genes most significantly associated with asthma. 19910030 2010
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. 24388013 2014
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Serum IL-33 Level and IL-33, IL1RL1 Gene Polymorphisms in Asthma and Multiple Sclerosis Patients. 30950351 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASDB Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. 21804549 2011