Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Identification of a new locus at 16q12 associated with time to asthma onset. 27130862 2016
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). 19198610 2009
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Interestingly, the IL1RL1, HLA, IL13 and C11orf30 regions are overlapping susceptibility loci among atopic dermatitis and asthma or allergic rhinitis. 23439055 2013
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Two-gene models implicating functional variants in the IL10 and VDR genes as well as in the IL10 and IL1RL1 genes were associated with asthma (p < 0.0002). 19852851 2009
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE The critical function of IL-33/ST2 signaling in allergic inflammation is illustrated by the fact that IL33 and IL1RL1 are among the most highly replicated susceptibility loci for asthma. 29247993 2018
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Polymorphisms in the IL33 and IL1RL1 can act as protective or risk factors for asthma and/or allergy in humans. 28266165 2017
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE We evidenced a new locus in the 16q12 region (near cylindromatosis turban tumor syndrome gene [CYLD]) and confirmed 4 asthma risk regions: 2q12 (IL-1 receptor-like 1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA]). 27130862 2016
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASDB Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. 23028483 2012
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503 2010
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE This review describes the mechanisms through which genetic variation at the IL33 and IL1RL1 loci translates into increased susceptibility for asthma. 23380221 2013
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. 30552067 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. 31619474 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. 24388013 2014
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Serum IL-33 Level and IL-33, IL1RL1 Gene Polymorphisms in Asthma and Multiple Sclerosis Patients. 30950351 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASDB Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. 21804549 2011
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Accordingly, this study aimed to determine the associations of IL1RL1 rs3771180 and TSLP rs1837253 with asthma in Zhuang people. 31066119 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. 29785011 2018
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. 21804549 2011
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with eosinophil counts and asthma. 28273074 2017
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01). 21150878 2011
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. 23028483 2012
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. 29273806 2018
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483 2012