Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE The aim of the present study was to determine the role of interleukin-33 in children sensitive to cat allergen with allergic rhinitis and/or asthma. 31477395 2020
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE Clinical trials support a central role for TSLP in driving airway inflammation and asthma exacerbations, while ongoing trials blocking IL-33 and IL-25 will help to define their respective role in asthma. 31408015 2020
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE Also, autophagy-deficient ILC2s were adoptively transferred into Rag<sup>-/-</sup>GC<sup>-/-</sup> mice, which were then challenged with IL-33 and assessed for AHR and lung inflammation. 31738991 2020
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 AlteredExpression disease BEFREE Our study demonstrated an increased expression of TSLP and IL-33 receptors on bronchial CD206 positive macrophages in asthma group. 30588853 2020
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 AlteredExpression disease BEFREE Modulation of ILC2 function by miR-146a may depend on IL-33/interleukin 1 receptor-like 1 (IL1RL1 or ST2) signaling through inhibiting IRAK1 and TRAF6.miR-146a can inhibit IRAK1 and TRAF6, downstream molecules of ST2 signal pathway, thereby negatively regulate IL-33/ST2-activated ILC2 to inhibit asthma. 31435003 2020
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE This study focused on discussing the role of IL-33 in airway remodeling in asthma. 31112061 2020
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 GeneticVariation disease BEFREE We conducted this study to evaluate the impact of the two most common SNPs of the IL-33 gene (rs1342326 and rs3939286) and environmental factors on the susceptibility to asthma in the Iranian population. 31820077 2020
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE Bronchial epithelial cell activation and release of cytokines, such as IL-33, IL-25 and TSLP play a major role in asthma. 31703832 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 GeneticVariation disease BEFREE The level of IL33 was significantly higher in asthma and MS patients compared to the control group (P< 0.001- P<0.001).The frequency distribution of the genotype in rs1342326 variant of IL-33 gene in patients with asthma, MS and healthy subjects was not significantly different (P>0.05). 30950351 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE <b>Objective:</b> To develop a detection method for single nucleotide polymorphisms (SNPs) of bronchial asthma (BA) susceptibility genes (<i>IL-13</i>, <i>IL-33,</i> and <i>GSDMA</i>) based on fluorescence PCR melting curves. 31082286 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 AlteredExpression disease BEFREE The mean protein levels of TSLP and IL-33 from BAL fluid of asthmatic mice were significantly higher until 7 days. 30861490 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE We show that TLR9 activation by CpG A suppresses IL-33-mediated AHR and airway inflammation through inhibition of ILC2s. 30914379 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 AlteredExpression disease BEFREE The level of IL-33 was significantly higher in patients with asthma when compared to healthy subjects (672.73 ± 104.47 pg/mL vs 268.52 ± 27.56 pg/mL, P < 0.05). 30303258 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE We demonstrated that low PEF variability over 1 week, high serum IL-10 level, and low serum IL-33 concentration were useful factors for predicting that an adult's asthma will remain in control for months to years after a 50% reduction in the daily ICS dose. 29221918 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 AlteredExpression disease BEFREE IL-33 EBC levels were significantly increased in IPF (3.41 ± 0.55 pg/ml) compared to healthy controls (1.20 ± 0.60 pg/ml; P < .01) but did not differ from asthma (3.68 pg/ml) and COPD levels (2.47 ± 0.34 pg/ml). 31392802 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 GeneticVariation disease GWASCAT Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. 31619474 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE Indeed, TSLP can condition dendritic cells to initiate type 2 responses, and IL-33 may influence susceptibility to asthma through its role in establishing the immune environment in the perinatal lungs. 30932910 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE Finally, the human and murine necroptosis inhibitor, GW806742X, blocked necroptosis and IL-33 release in vitro and reduced eosinophilia in Aspergillus fumigatus extract-induced asthma in vivo, an allergic inflammation model that is highly dependent on IL-33. 30576068 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE In particular, we will focus on the evidence for IL-33 in the development of immune responses in the lung, including the role of IL-33-responsive immune cells that may explain susceptibility to allergic sensitization at a young age and the association between genetic variants of IL-33 and asthma in humans. 30734382 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE The emergence of IL-33 as a key molecular player in the development and propagation of widespread inflammatory diseases, including asthma and atopic dermatitis, has established the need for effective IL-33-neutralizing biologics. 30876911 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE Interleukin-33 is released in the airways following acute ozone exposure and has the ability to cause airway hyperresponsiveness, a defining feature of asthma. 31455422 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 Biomarker disease BEFREE ST2 OE also enhanced HRV1B-induced IP-10, a chemokine involved in asthma exacerbations.In the <i>M. pneumoniae</i>-infected mouse model, ST2 deficiency, in contrast to sufficiency, significantly reduced the levels of neutrophils following acute (≤24 h) infection, while in the HRV1B-infected mouse model, ST2 deficiency significantly reduced the levels of proinflammatory cytokines KC, IP-10, and IL-33 in bronchoalveolar lavage (BAL) fluid. 31061143 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 GeneticVariation disease BEFREE Single nucleotide polymorphisms in the IL-33 gene cause a predisposition to the development of asthma. 31057533 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 GeneticVariation disease BEFREE Several genome wide association studies have found SNPs in genes encoding IL-33 to be risk factors for asthma. 31490928 2019
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.500 AlteredExpression disease BEFREE We found that IL-33-activated ILC2s were crucial for the development of AHR and airway inflammation, during RSV infection. 31622507 2019