Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. 29273806 2018
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population. 28266165 2017
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease CTD_human IL-33 Drives Augmented Responses to Ozone in Obese Mice. 27472835 2016
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE IL-33 is likely to play a critical role in asthma because the IL33 and ST2/IL1RL1 genes have been reproducibly identified as major susceptibility loci in large-scale genome-wide association studies. 25313073 2015
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma. 25091434 2015
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. 24388013 2014
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease CTD_human Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma. 24241537 2014
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma. 24241537 2014
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood. 24568840 2014
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483 2013
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE TH2 pathway genes (IL13, TSLP, IL33, and IL1RL1) conferring asthma susceptibility were not associated with lung function. 23541324 2013
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology. 23380221 2013
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Interestingly, the IL1RL1, HLA, IL13 and C11orf30 regions are overlapping susceptibility loci among atopic dermatitis and asthma or allergic rhinitis. 23439055 2013
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483 2013
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASDB We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483 2013
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE Clinical and genetic studies indicate that IL1RL1 plays an important role in the development and exacerbations of asthma. 22574108 2012
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE Genome-wide association studies have begun to identify genes underlying asthma (e.g., IL1RL1), which represent future therapeutic targets. 22455494 2012
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE Targeting ST2L potentiates CpG-mediated therapeutic effects in a chronic fungal asthma model. 21640974 2011
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease CTD_human In conclusion, we confirm the association between asthma risk and variants in ORMDL3 and identify a novel risk variant in IL1RL1. 21150878 2011
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease CTD_human Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia. 21150878 2011
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. 21804549 2011
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease CTD_human Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. 21804549 2011
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE Associations with variation in genes encoding the epithelial cell-derived cytokines, interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), and the IL1RL1 gene encoding the IL-33 receptor, ST2, highlight the central roles for innate immune response pathways that promote the activation and differentiation of T-helper 2 cells in the pathogenesis of both asthma and allergic diseases. 21682736 2011
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASDB Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. 21804549 2011
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease CTD_human However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01). 21150878 2011