Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 AlteredExpression disease BEFREE Modulation of ILC2 function by miR-146a may depend on IL-33/interleukin 1 receptor-like 1 (IL1RL1 or ST2) signaling through inhibiting IRAK1 and TRAF6.miR-146a can inhibit IRAK1 and TRAF6, downstream molecules of ST2 signal pathway, thereby negatively regulate IL-33/ST2-activated ILC2 to inhibit asthma. 31435003 2020
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. 30552067 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. 31619474 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Serum IL-33 Level and IL-33, IL1RL1 Gene Polymorphisms in Asthma and Multiple Sclerosis Patients. 30950351 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Accordingly, this study aimed to determine the associations of IL1RL1 rs3771180 and TSLP rs1837253 with asthma in Zhuang people. 31066119 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults. 30578877 2019
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 AlteredExpression disease BEFREE Plasma and sputum IL-33, soluble ST2 (sST2) levels, and ST2L expression on eosinophils were measured in 10 healthy controls and 10 allergic asthmatics. 29694974 2018
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE The critical function of IL-33/ST2 signaling in allergic inflammation is illustrated by the fact that IL33 and IL1RL1 are among the most highly replicated susceptibility loci for asthma. 29247993 2018
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. 29785011 2018
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE This study aimed to characterize DNA methylation (DNA-me) in promoter region of IL33, IL1RL1 and CCL26 in asthma and their impacts on transcriptional activity in bronchial epithelial cells (BECs). 30468398 2018
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. 29273806 2018
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE We uncovered several promising tissue-specific regulatory TFs or genes for Alzheimer's disease (e.g.ZIC1 and STX1B) and asthma (e.g.CSF3 and IL1RL1). 29378629 2018
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 AlteredExpression disease BEFREE IL1RL1-a levels negatively correlated with blood eosinophil counts, whereas there was no association between IL1RL1-a levels and asthma.In conclusion, asthma-associated <i>IL1RL1</i> SNPs strongly regulate <i>IL1RL1</i> methylation and serum IL1RL1-a levels, yet neither these <i>IL1RL1-</i>methylation CpG sites nor IL1RL1-a levels are associated with asthma. 29519908 2018
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Polymorphisms in the IL33 and IL1RL1 can act as protective or risk factors for asthma and/or allergy in humans. 28266165 2017
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease CTD_human IL-33 Drives Augmented Responses to Ozone in Obese Mice. 27472835 2017
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with eosinophil counts and asthma. 28273074 2017
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Identification of a new locus at 16q12 associated with time to asthma onset. 27130862 2016
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease BEFREE We evidenced a new locus in the 16q12 region (near cylindromatosis turban tumor syndrome gene [CYLD]) and confirmed 4 asthma risk regions: 2q12 (IL-1 receptor-like 1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA]). 27130862 2016
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 AlteredExpression disease BEFREE ST2L expression was increased in severe asthma (P = .02) and associated with multiple indicators of TH2-like inflammation, including blood eosinophils (P = .001), exhaled nitric oxide (P = .003), and epithelial CLCA1 (P < .0001) and eotaxin-3 (P = .001) mRNA expression. 25091434 2015
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease CTD_human Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma. 24241537 2014
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE IL-33 is likely to play a critical role in asthma because the IL33 and ST2/IL1RL1 genes have been reproducibly identified as major susceptibility loci in large-scale genome-wide association studies. 25313073 2014
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 GeneticVariation disease GWASCAT Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. 24388013 2014
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
0.500 Biomarker disease BEFREE Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma. 24241537 2014