Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 GeneticVariation disease GWASCAT Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. 29273806 2018
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 GeneticVariation disease BEFREE Interleukin-13 +2044 G/A and +1923C/T polymorphisms are associated with asthma susceptibility in Asians: A meta-analysis. 29390465 2018
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE Role of IL-13 Genetic Variants in Signalling of Asthma. 28083766 2017
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 GeneticVariation disease BEFREE Self-Reported Allergic Rhinitis and/or Allergic Conjunctivitis Associate with IL13 rs20541 Polymorphism in Finnish Adult Asthma Patients. 28273659 2017
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE Docking analysis and the possibility of prediction efficacy for an anti-IL-13 biopharmaceutical treatment with tralokinumab and lebrikizumab for bronchial asthma. 29155876 2017
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE Interleukin 4 (IL4), interleukin 4 receptor (IL4R) and interleukin 13 (IL13) play a key role in the pathogenesis of allergy and asthma development. 26426602 2017
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma. 28024734 2017
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 GeneticVariation disease BEFREE Association between IL-13 +1923C/T polymorphism and asthma risk: a meta-analysis based on 26 case-control studies. 28057889 2017
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE Furthermore, both pendrin and periostin levels (a biomarker in asthma) correlated with IL-13 levels, suggesting that pendrin can be induced by this cytokine in sinonasal tissues. 26143180 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE In sharp contrast, B7-H3 KO mice developed severe ovalbumin (OVA)-induced asthma with characteristic infiltrations of eosinophils in the lung, increased IL-5 and IL-13 in lavage fluid, and elevated IgE anti-OVA antibodies in the blood. 26065426 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE Furthermore, the in vivo blockade of IL-4 and/or IL-13 in an asthma model not only increases the density but also enhances the function of lung LVs. 25648335 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE The data suggests that gene-gene interactions between IL 13 and IL 4 R genes may play an important role in asthma among Indian children. 25402004 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 AlteredExpression disease BEFREE NF-kB inhibitor blocked IL-4/IL-13-induced increase in B2R expression in cultured fibroblasts, suggesting a role as potential anti-asthma drug. 26588817 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 GeneticVariation disease BEFREE When compared to children with each CC of TLR4 polymorphism or TT of CD14 polymorphism or GG of IL13 polymorphism and no past history of bronchiolitis, children with CT or TT of TLR4 polymorphism and past history of bronchiolitis had 4.23 and 5.34 times higher risk to develop asthma, respectively; children with TT of CD14 polymorphism and past history of bronchiolitis had 3.57 and 7.22 times higher risk for asthma, respectively; children with GA or AA of IL-13 polymorphism and past history of bronchiolitis had 3.21 and 4.13 times higher risk for asthma, respectively. 24376096 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 GeneticVariation disease BEFREE An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma. 26986948 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 AlteredExpression disease BEFREE The in vitro increase in response to IL-13 suggests that type 2 cytokines regulate BDNF levels and activity in asthma. 25945802 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 AlteredExpression disease BEFREE The effect of IL-13 on ELN expression was significantly correlated with postbronchodilator FEV1/FVC in patients with asthma. 26074138 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 GeneticVariation disease BEFREE Selected single nucleotide polymorphisms (SNPs) were analysed as potential markers for asthma susceptibility and severity in the interleukin 4 (IL4), interleukin 13 (IL13), beta-2-adrenergic receptor (ADRB2), a disintegrin and metalloprotease 33 (ADAM33), gasdermin-like (GSDML) and the signal transducer and activator of transcription 6 (STAT6) genes comparatively to a population reference set. 25299150 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE These data identify a role for 1,25D3 in the molecular programming of CD8(+) T-cell conversion to an IL-13-secreting phenotype through regulation of steroidogenesis, potentially governing asthma susceptibility. 26750596 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE IL13_rs1295686 was associated with all asthma (OR 1.64, 95% CI 1.16-2.32) and early-onset asthma (OR 1.92, 95% CI 1.20-3.06) in adults, whereas GSDMB_rs2305480 was only associated with early-onset asthma (OR 0.69, 95% CI 0.49-0.96). 26534891 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 GeneticVariation disease BEFREE Lack of association between RAD50-IL13 polymorphisms and pediatric asthma susceptibility in Northeastern Han Chinese. 26365633 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE A preliminary study on the association of single nucleotide polymorphisms of interleukin 4 (IL4), IL13, IL4 receptor alpha (IL4Rα) & Toll-like receptor 4 (TLR4) genes with asthma in Indian adults. 26831416 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium. 25848896 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE Allergic rhinitis (AR) and asthma are common allergic conditions with a shared genetic component to their cause. 26483175 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.700 Biomarker disease BEFREE Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways. 26474238 2016