Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE The intercellular adhesion molecule-1 (ICAM-1)/leukocyte function associated antigen-1 (LFA-1) adhesion system regulates leukocyte interactions, migration, and adhesion, and appears to play an important role in atherosclerosis and thrombosis. 31157518 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Endothelial markers, ICAM-1 and VCAM-1, are implicated in atherosclerosis and associated with cardiovascular risk. 31370809 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE The expression of macrophage migration inhibitory factor and intercellular adhesion molecule-1 in rats with periodontitis and atherosclerosis. 31442933 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Endothelial function and atherosclerosis were examined by nitric oxide-related-products (NOx: NO2- and NO3-), O2-, endothelial NO synthase (eNOS), NADPH oxidase (p22phox), and ICAM1. 31266015 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE MANTIS is tightly regulated by the transcription factors KLF2 and KLF4 and limits the ICAM-1 mediated monocyte adhesion to endothelial cells and thus potentially atherosclerosis development in humans. 31222221 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Intercellular adhesion molecule-1 (ICAM-1) is a member of an immunoglobulin-like superfamily of adhesion molecules that mediate leukocyte adhesion to vascular endothelium and are involved in several cardiovascular diseases, including ischemia-reperfusion injury, myocardial infarction, and atherosclerosis. 31729904 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Soluble ICAM 1 and VCAM 1 Blood Levels Alert on Subclinical Atherosclerosis in Non Smokers with Asymptomatic Metabolic Syndrome. 31349950 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Intercellular adhesion molecule-1 (ICAM-1) is a proinflammatory and proatherogenic cytokine which is associated with atherosclerosis, insulin resistance, and cardiovascular disease (CVD). 31629408 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE This study aimed to evaluate the feasibility and accuracy of a technique for atherosclerosis imaging using local delivery of relatively small quantities (0.04-0.4 mg/kg) of labeled-specific imaging tracers targeting ICAM-1 and unpolymerized type I collagen or negative controls in 13 rabbits with atheroma induced by balloon injury in the abdominal aorta and a 12-week high-cholesterol diet. 30804367 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE In addition, PM<sub>1</sub> upregulated ICAM-1 expression in EA.hy926 cells through TNF-α/NF-κB signaling pathways, promoting the adhesion of endothelial cells and monocytes, a key event in the initiation of atherosclerosis. 30858030 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE The levels of CLOCK, leukemia inhibitory factor (LIF), intercellular adhesion molecule 1 (ICAM-1), perilipin 2 (ADFP), nuclear factor kappa B (NF-κB), and plasminogen activator inhibitor-1 (PAI-1), as well as the number of atherosclerotic plaques were elevated in the AS mouse model, as compared with the control group. 30124738 2018
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE In summary, our study has established that Ginkgolide B ameliorates endothelial dysfunction via targeting LOX-1, NOX-4, MCP-1, ICAM-1, and VCAM-1 along with the markers associated with inflammatory cascades and thus could be promoted as a valuable therapeutic agent in prevention and management of atherosclerosis. 30136446 2018
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE Our results showed that administration of 100μM of H<sub>2</sub>O<sub>2</sub> on HUVECs for 2, 6, 12 and 24 h induced a time-dependent increase in ICAM-1 and VCAM-1 mRNA and protein expression levels with a significant increase observed from 6 h. HUVECs exposed to H<sub>2</sub>O<sub>2</sub> exhibit increased O<sub>2</sub><sup>-</sup>, suggesting that H<sub>2</sub>O<sub>2</sub> induced oxidative stress may be a reasonable for atherosclerosis. 30309503 2018
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE A mouse model of atherosclerosis was induced by feeding Apoe<sup>-/-</sup> mice a hypercholesterolemic diet and was verified with hematoxylin and eosin staining and intercellular adhesion molecule 1 (ICAM-1) expression. 30150423 2018
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Inhibition of PARP decreases vascular endothelial cell adhesion P-selectin and ICAM-1 molecules, inflammatory cells, pro-death caspase-3, and c-Jun N-terminal kinase (JNK) activation and upregulates prosurvival extracellular signal-regulated kinases and AKT, which decrease vascular cell apoptosis and necrosis and limit atherosclerosis and plaque disruption. 29968072 2018
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE The present review highlights the role of various miRNAs in controlling the expression of E-selectin, ICAM-1, and VCAM-1: a type of regulation that can be harnessed for therapeutic prevention of inflammation-associated diseases such as atherosclerosis and sepsis. 29565737 2018
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE We found that atherosclerosis progression was markedly attenuated in mice deleted for ShcA in endothelial cells, that macrophage content was reduced at the sites of lesions, and that adhesion molecules such as the intercellular adhesion molecule-1 (ICAM-1) were severely reduced. 29540796 2018
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Essential role of ICAM-1 in aldosterone-induced atherosclerosis. 28089144 2017
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Intercellular adhesion molecule-1 (ICAM1) is crucial to the development and progression of atherosclerosis. 28095483 2017
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE ICAM-1 overexpression and subsequent adhesion of leukocytes to endothelial cells play critical roles in the early stage of atherosclerosis. 29021525 2017
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Furthermore, PCB126 exposure in MCD-fed mice led to increased plasma inflammatory markers such as Icam-1, plasminogen activator inhibitor-1 and proatherogenic trimethylamine-N-oxide, suggesting inflammation of the peripheral vasculature that is characteristic of atherosclerosis. 28973532 2017
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE Atherosclerosis PCR array and qPCR analyses showed upregulation of adhesion molecules such as intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin in HAECs upon SAA stimulation. 27799725 2016
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 AlteredExpression disease BEFREE An increased level of the ICAM 1 molecule is associated with numerous inflammatory diseases including atherosclerosis of carotid arteries. 27090396 2016
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE Intercellular adhesion molecule-1 (ICAM-1) displays an important role in the development of the inflammation reaction and atherosclerosis. 26078712 2015
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.400 Biomarker disease BEFREE We found that SAA (80μg/mL) induced 3.5- to 37.8-fold increases in the expression of targets known to play important roles in the initiation and progression of atherosclerosis (i.e., ICAM-1, MCP-1, MMP-9 and TF) via NF-κB regulation within one hour after exposure. 24785395 2014