Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease BEFREE Forkhead box protein O1 (FOXO1s) family and 5-lipoxygenase make an important contribution to atherosclerosis. 30825235 2019
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease BEFREE It is well known that 5-LOX activation in innate immunity cells is related to different iron-associated pro-inflammatory disorders, including cancer, neurodegenerative diseases, and atherosclerosis. 31316498 2019
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 GeneticVariation disease BEFREE ALOX5 gene variants do not appear to be related to clinical CHD events or subclinical atherosclerosis regardless of bioavailable enzyme substrate levels in this multiethnic cohort. 27025886 2016
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease BEFREE The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atherosclerosis. 25721704 2015
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease BEFREE The 5-lipoxygenase activating protein (FLAP), encoded by the activating 5-lipoxygenase (ALOX5AP) gene, is a crucial mediator of the biosynthesis of leukotrienes, which have been implicated in atherosclerosis. 22726381 2012
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease BEFREE Polymorphisms within ALOX12, ALOX5, and ALOX5AP are genetically associated with subclinical atherosclerosis and with biomarkers of disease in families with type 2 diabetes. 20592751 2010
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease BEFREE Inhibiting the 5-lipoxygenase pathway through either leukotriene synthesis inhibitors or leukotriene receptor antagonists in experimental models of atherosclerosis has however generated contradictory results. 19754386 2009
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 AlteredExpression disease BEFREE Using a pathway-based approach, we also detected statistical evidence for interactions among ALOX5, ALOX5AP and LTA4H using RNA expression data from a collection of freshly harvested human aortas with varying degrees of atherosclerosis. 19130089 2009
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease BEFREE Both experimental and clinical studies implicate the 5-lipoxygenase pathway in the pathophysiology of atherosclerosis. 18179798 2008
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 AlteredExpression disease BEFREE The increase of 5-LO and FLAP mRNA expression confirms their role as inflammatory markers associated to atherosclerosis. 18258817 2008
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease BEFREE Cyclo-oxygenases (COXs) and 5-lipoxygenase (5-LO) are the key enzymes in the conversion of arachidonic acid to prostaglandins (PG) and leukotrienes (LT) and are implicated in a wide variety of inflammatory disorders, including atherosclerosis. 18991687 2008
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 GeneticVariation disease BEFREE The 3 and 4 variants lead to higher 5-LO expression and provide additional evidence that these alleles are associated with greater risks of atherosclerosis and MI in the context of a high-AA diet. 18842779 2008
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 GeneticVariation disease LHGDN The 3 and 4 variants lead to higher 5-LO expression and provide additional evidence that these alleles are associated with greater risks of atherosclerosis and MI in the context of a high-AA diet. 18842779 2008
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease BEFREE We previously used an integrative genetics approach to demonstrate that 5-lipoxygenase (5-LO) deficiency in mice (Alox5 (-/-)) protects against atherosclerosis despite increasing lipid levels and fat mass. 18421434 2008
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease BEFREE Human and animal studies have suggested a role for the ALOX5 gene in atherosclerosis, including a significant association between a promoter polymorphism and a carotid intimal-medial thickness in response to dietary fat. 17373938 2007
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease BEFREE Second, the involvement of 5-lipoxygenase and leukotrienes in atherosclerosis. 17481551 2007
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 GeneticVariation disease BEFREE Studies in mice followed by several extensive clinical studies have identified ALOX5 and ALOX5AP polymorphisms as strong risk factors for atherosclerosis and cerebrovascular pathologies. 16278051 2006
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease CTD_human In contrast to human plaques, levels of 5-LO mRNA are not significantly increased in plaque tissues from two atherosclerosis-prone mouse strains, and mouse plaques exhibit segregated cellular expression of LTA4H and 5-LO as well as strong increases of CysLT1 and CysLT2 mRNA. 16698924 2006
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease BEFREE The 5-lipoxygenase pathway has been strongly implicated in the pathogenesis of chronic inflammatory disorders, such as bronchial asthma and atherosclerosis. 16210619 2005
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 GeneticVariation disease BEFREE We determined 5-lipoxygenase genotypes, carotid-artery intima-media thickness, and markers of inflammation in a randomly sampled cohort of 470 healthy, middle-aged women and men from the Los Angeles Atherosclerosis Study. 14702425 2004
Entrez Id: 240
Gene Symbol: ALOX5
ALOX5
0.400 Biomarker disease BEFREE Studies of the 5LO pathway in other disease areas suggest that 5LO could contribute to atherosclerosis at different levels, such as lesion initiation, growth and cellular proliferation within the lesion, and/or destabilization of plaques that can lead to their rupture. 14501583 2003