Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression group BEFREE Urinary IL-1β levels might be a useful tool to identify patients with challenging MDR bacterial infections. 31820023 2020
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression group BEFREE To mimic immune response to bacterial infection, human monocytic leukemia cells (THP-1) were stimulated with lipopolysaccharide (LPS), and the expression of two inflammatory genes, IL1β (interleukin 1β) and TNF-α (tumor necrosis factor α), were simultaneously quantified by monitoring the intron, mRNA, and protein levels over time. 31002726 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker group BEFREE For the studied Th1 cytokines (IFN, TNF, IL-6, and IL-1), only IFN showed a significant decrease as a consequence of bacterial infection in mechanically ventilated rats. 31614857 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression group BEFREE Consistent with the <i>in vitro</i> results, intraperitoneal administration of paclitaxel significantly increased serum IL-1β levels, reduced bacterial burden, dampened infiltration of inflammatory cells in the liver, and improved animal survival in a mouse model of bacterial infection. 30761140 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker group BEFREE AIM2 senses Brucella abortus DNA in dendritic cells to induce IL-1β secretion, pyroptosis and resistance to bacterial infection in mice. 30248400 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker group BEFREE Neutrophils are an important source of IL-1β secretion in bacterial infections, where they infiltrate affected tissues in log-fold higher numbers than macrophages. 30266768 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker group BEFREE Nonetheless, we found that MEG3-4 bound to the microRNA miR-138 in a competitive manner with mRNA encoding the proinflammatory cytokine interleukin-1β (IL-1β), thereby increasing IL-1β abundance and intensifying inflammatory responses to bacterial infection in alveolar macrophages and lung epithelial cells in culture and in lung tissue in mice. 29945883 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker group BEFREE IL-1α and IL-1β were detectable in BAL in absence of infection, increased in the presence of bacterial infection and correlated with IL-8 (p < 0.0001), neutrophils (p < 0.0001) and NE activity (p < 0.01 and p < 0.001). 29884450 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 GeneticVariation group BEFREE This insight into the mechanisms involved in IL-1 release from primary human monocytes highlights major differences between immune cell types, and the defences they employ during bacterial infection. 28761045 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker group BEFREE These results indicate that IL-1β, produced by the inflammasome and Fas-dependent mechanisms, contributes cooperatively to the Th17/Th1 induction during bacterial infection. 28674179 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker group BEFREE Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections. 28051086 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression group BEFREE Additionally, IL1β levels are increased in atherosclerotic plaques and in bacterial infections. 24458711 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker group BEFREE Microarray and quantitative PCR analysis revealed that expression of genes for transcription factors central to innate immunity (including NF-ĸB and AP-1) and the pro-inflammatory cytokine Il1b, is dependent on MyD88 signaling during these bacterial infections. 23471913 2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 AlteredExpression group BEFREE IL1B expression was elevated in the presence of either conjunctival bacterial infection (P = 0.011) or inflammation (P = 0.002). 20237245 2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 GeneticVariation group BEFREE Cutting edge: expression of IL-1 receptor-associated kinase-4 (IRAK-4) proteins with mutations identified in a patient with recurrent bacterial infections alters normal IRAK-4 interaction with components of the IL-1 receptor complex. 15905496 2005
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker group BEFREE IRAK-M(-/-) cells exhibited increased cytokine production upon TLR/IL-1 stimulation and bacterial challenge, and IRAK-M(-/-) mice showed increased inflammatory responses to bacterial infection. 12150927 2002
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker group BEFREE Because LPS-stimulated PGE2 and IL-1beta production was enhanced by in vivo cellular aging, aging of GF may affect the severity of inflammation and bone resorption by producing a large amount of PGE2 and IL-1beta in response to bacterial infection. 10433392 1999