Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker group BEFREE For the studied Th1 cytokines (IFN, TNF, IL-6, and IL-1), only IFN showed a significant decrease as a consequence of bacterial infection in mechanically ventilated rats. 31614857 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker group BEFREE PCT and IL-6 are promising markers in identifying bacterial infection in children with cancer and FN. 29777383 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 AlteredExpression group BEFREE In this study, Nile tilapia (Oreochromis niloticus) IL-6 (OnIL-6) was identified and characterized at expression level in response to bacterial infection and promotion of antibody production. 30142358 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker group BEFREE Blocking IL-6 trans-signaling does not compromise the defense of the body against bacterial infections. 28675418 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker group BEFREE In conclusion, PCT, CRP, and lL-6 can act as early diagnostic markers for bacterial infections in patients with septicopyemia. 28587428 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 AlteredExpression group BEFREE IL-6 levels also showed higher AUROC than CRP for predicting bacterial infection in the AD cohort (0.831±0.043vs.0.763±0.048, respectively). 28082235 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker group BEFREE This work reported an ultrasensitive and quantitative microfluidic immunoassay combined with the streptavidin-biotin-peroxidase (SA-B-HRP) nanocomplex-signal amplification system (MIS) to detect two inflammatory biomarkers, procalcitonin (PCT, for discriminating bacterial infections from nonbacterial infections) and interleukin-6 (IL-6, for monitoring the kinetics of infectious disease) simultaneously. 28734353 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker group BEFREE In conclusion, IL-6 combined with PCT can serve as an indicator with high sensitivity for detection of severe bacterial infections in children, which is of great significance for the differential diagnosis of severe bacterial infections in the early stage. 28587429 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker group BEFREE Furthermore, the expression and secretion of TNF-α and IL-6 in gingival tissue was significantly decreased in LG2055-administered mice after bacterial infection. 28373699 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker group BEFREE In this study, we demonstrate that IFNα, a cytokine that modulates the early innate immune responses toward viral and bacterial infections, potently enhances the production of IL-6 in neutrophils stimulated with R848, a TLR8 agonist. 26790609 2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 GeneticVariation group BEFREE Markers for diagnosis of bacterial infection, which includedprocalcitonin (PCT), interleukin-6 (IL-6), and highly sensitive C-reactive protein (hs-CRP), were measured by enzyme-linked immunosorbent assay (ELISA). 25881528 2015
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker group BEFREE Increased mast cell IL-6 production in response to combined TLR2 and NLR activation could play a role in the protection against bacterial infection, but potentially exacerbate inflammation-dependent conditions. 20861644 2011
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 AlteredExpression group BEFREE Bacterial infection (LPS) or metabolic alterations (palmitate) have distinct effects on IL-6 expression in hBSMC, (i) short term LPS induced autocrine JAK/STAT signaling and (ii) long-term endocrine regulation of IL-6 by palmitate. 20526368 2010
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 AlteredExpression group BEFREE Target genes of the NF-kappaB pathway, such as interleukin-6, were correspondingly down-regulated during bacterial infection with Salmonella expressing AvrA. 17690189 2007
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker group BEFREE Matrix metalloproteinase (MMP)1, interleukin(IL)6 and vitamin D receptor (VDR) have been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection, resulting in periprosthetic bone loss around loosened total hip replacements (THRs). 17363400 2007
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 AlteredExpression group LHGDN Analysis of all data clearly showed that the majority of elevated IL-6 levels occurred in connection with bacterial infections. 17362770 2007
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 Biomarker group BEFREE The possible role of the proinflammatory cytokines interleukin (IL)-1, tumor necrosis factor-alpha, IL-6, and IL-8 as modulators of host resistance to bacterial infections is discussed. 9917883 1998