Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Neither the BD-associated genetic risk locus within the HLA-B/MICA region nor being on immunosuppressive medications explained the differences between patients and controls. 27283393 2016
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE We found that the HLA-B*51 allele and the rs76546355/rs116799036 MHC SNP are independent genetic risk factors for BD in Iranian, and that positivity for the rs76546355/rs116799036 risk allele, but not for B*51, does correlate with specific demographic characteristics or clinical manifestations in BD patients. 25889189 2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE The repeated RPE analysis after separating HLA-B alleles carrying B51-KIR binding sequence as distinct alleles within a broad-type allele group revealed B*2702 allele as the only allele showing an association with BD after the deletion of B*51. 12209364 2002
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE In the current study of Behçet disease (BD), nonsynonymous variants (NSVs) identified by deep exonic resequencing of 10 genes found by GWAS (IL10, IL23R, CCR1, STAT4, KLRK1, KLRC1, KLRC2, KLRC3, KLRC4, and ERAP1) and 11 genes selected for their role in innate immunity (IL1B, IL1R1, IL1RN, NLRP3, MEFV, TNFRSF1A, PSTPIP1, CASP1, PYCARD, NOD2, and TLR4) were evaluated for BD association. 23633568 2013
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE The significant increase of HLA-A*2602 and B*3901 in the patient group without HLA-B*51 suggests that these two alleles might also have some secondary influence on the onset of BD. 16671946 2006
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Association of MICA gene and HLA-B*5101 with Behçet's disease in Greece. 10440244 1999
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE In this study, HLA-B*5101 gene from 37 individuals including Japanese, Turkish, Jordanian and Iranian patients and healthy controls were fully sequenced to further clarify the B*5101 gene in association with BD. 18700875 2008
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Since the identification of HLA-B*5101 (and more recently of MICA) as a susceptibility locus for BD, the identification of additional genetic locus/loci, whether inside, or perhaps more importantly outside the MHC has clearly stalled. 19684014 2010
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease GWASDB Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. 20622878 2010
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE The evaluation of the IL-2 gene polymorphism (p=0.0065) and IL-10 gene polymorphism (p=0.0483) distributions with respect to age of BD onset revealed a statistically significant distribution. 26654556 2016
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Both HLA-B*51 and MICA*009 are strongly associated with BD in a pure Caucasian BD patient group, and the two alleles are in linkage disequilibrium. 16101830 2005
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease GWASDB Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. 23291587 2013
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Our findings suggest that gene-gene interactions between HLA-B*51 and ERAP1 variants is important for BD development, however, ERAP1 variants which interact with HLA-B*51 may differ among disease phenotypes or populations. 30514861 2018
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Behçet's disease and genetic interactions between HLA-B*51 and variants in genes of autoinflammatory syndromes. 30808881 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE Thus, this study aimed to investigate the associations between IL-6 and IL-10 promoter single-nucleotide polymorphisms (SNPs) and the susceptibility to BD and their implication on plasma levels. 24703990 2014
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Microsatellite analysis revealed that the HLA-B*51 gene was strongly associated with Behçet's disease in a Korean population. 22258392 2012
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE In order to investigate the influence of the MICB gene, located about 120 kb centromeric of the HLA-B gene, on the susceptibility to BD, (CA/TG) dinucleotide repeat microsatellite polymorphism in intron 1 of the MICB gene was investigated among 77 Japanese patients with BD, 60 randomly selected controls and 28 HLA-B51-positive unrelated healthy controls. 9712354 1998
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE Therefore, the goal of this study was to measure the correlation of the IL-10 gene polymorphisms with the susceptibility to Behçet's disease compared with the control group in the Azeri population and to determine the expression of this gene in the two groups. 29294320 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD. 26213801 2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Although we were not able to formally replicate the association with IL10 and IL23R-IL12RB2, we do report that BD in Iran is strongly associated with HLA-B*51, MICA-A6, and the three HLA-linked SNPs (odds ratio (OR) = 3.38, P = 6.21 × 10(-14); OR = 2.08, P = 1.58 × 10(-13); and OR = 1.67-4.05, P = 1.45 × 10(-04) to 4.79 × 10(-34), respectively). 25940109 2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE As it is now known that the B51 antigen can be encoded by 21 alleles, B*5101-B*5121, we performed HLA-B*51 allele genotyping among 58 Greek patients with BD. 12028538 2002
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE Behçet's disease (BD) susceptibility had been associated with single-nucleotide polymorphisms (SNPs) in IL23R-IL12RB2, IL10, STAT4, or ERAP1 locus in Japanese, Turkish, Chinese, and other populations, but not in a Korean genome-wide association study (GWAS). 29017598 2017
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE In this Perspectives article, we describe how Behçet disease and several clinically distinct spondyloarthropathies-all associated with MHC class I (MHC-I) alleles such as HLA-B(*)51, HLA-C(*)0602 and HLA-B(*)27 and epistatic ERAP-1 interactions-have a shared immunopathogenetic basis. 26526644 2015
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Our data suggest that the robust HLA-B*51 association in Behçet's disease is explained by a variant located between the HLA-B and MICA genes (rs116799036: odds ratio (OR) = 3.88, P = 9.42 × 10(-50)). 23396137 2013
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Genetic evidence supports that the susceptible gene for Behçet's disease is the HLA-B51 allele at the HLA-B locus. 11696219 2001