Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 GeneticVariation disease BEFREE Along with human leukocyte antigen gene encoding B*51 (HLA-B*51) and areas including the major histocompatibility complex class I, genome-wide association studies have recognized numerous other BD susceptibility genes including those encoding interleukin (IL)-10, IL-12 receptor β 2 (IL-12RB2), IL-23 receptor (IL-23R), C-C chemokine receptor 1 gene, signal transducer and activator of transcription 4 (STAT4), endoplasmic reticulum aminopeptidase (ERAP1), and genes encoding killer cell lectin-like receptor family members (KLRC4-KLRK1). 30341905 2019
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 GeneticVariation disease BEFREE Behçet's disease (BD) susceptibility had been associated with single-nucleotide polymorphisms (SNPs) in IL23R-IL12RB2, IL10, STAT4, or ERAP1 locus in Japanese, Turkish, Chinese, and other populations, but not in a Korean genome-wide association study (GWAS). 29017598 2017
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 SusceptibilityMutation disease ORPHANET Brief report: association of CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 With Behçet's disease in Iranians. 26097239 2015
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 GeneticVariation disease BEFREE Six SNPs (in decreasing order of significance, rs7616215 located 38 kb downstream of CCR1, rs2617170 [rs2617170;rs281860419" genes_norm="3107;8302">p.Asn104Ser] in KLRC4, rs17810546 in IL12A-AS1, rs7574070 in STAT4, and rs10050860 [rs10050860" genes_norm="51752">p.Asp575Asn] and rs13154629 in ERAP1) were nominally associated with BD in both allelic association tests (5.05 × 10(-9) ≤ Pallele ≤ 7.55 × 10(-3) ) and sex-adjusted genotypic association tests (6.01 × 10(-9) ≤ adjusted P value ≤ 1.30 × 10(-2) ). 26097239 2015
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 GeneticVariation disease GWASCAT Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. 23291587 2013
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 GeneticVariation disease GWASDB Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. 23291587 2013
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 Biomarker disease CTD_human Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. 23291587 2013
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 GeneticVariation disease GWASDB Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study. 23001997 2012
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 Biomarker disease BEFREE Significant associations were found between Behçet's disease and STAT4, IL23R, CD40, CCR1/CCR3, STAT3, MCP-1, TGFBR3, FCRL3, SUMO4, UBAC2. 23161479 2012
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 SusceptibilityMutation disease ORPHANET Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study. 23001997 2012
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 GeneticVariation disease GWASCAT Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study. 23001997 2012
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 Biomarker disease BEFREE We propose a model in which up-regulation of STAT4 expression and subsequent STAT4-driven production of inflammatory cytokines, such as IL-17, constitute a potential pathway leading to BD. 23001997 2012
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 GeneticVariation disease BEFREE Our results indicate that the interaction of specific IL17A, IL23R, and STAT4 SNPs modulate susceptibility to intestinal BD in the Korean population, suggesting that the IL-17/23 axis plays a significant role in disease pathogenesis. 22483685 2012
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
0.670 GeneticVariation disease BEFREE A binary logistic regression analysis was used to assess the influence of the gender on the association of STAT4 polymorphism with BD. 20438790 2010