Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 Biomarker disease BEFREE Our study strengthens the association between ERAP1 and BS. 31790864 2020
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE Along with human leukocyte antigen gene encoding B*51 (HLA-B*51) and areas including the major histocompatibility complex class I, genome-wide association studies have recognized numerous other BD susceptibility genes including those encoding interleukin (IL)-10, IL-12 receptor β 2 (IL-12RB2), IL-23 receptor (IL-23R), C-C chemokine receptor 1 gene, signal transducer and activator of transcription 4 (STAT4), endoplasmic reticulum aminopeptidase (ERAP1), and genes encoding killer cell lectin-like receptor family members (KLRC4-KLRK1). 30341905 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Behçet's disease and genetic interactions between HLA-B*51 and variants in genes of autoinflammatory syndromes. 30808881 2019
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 Biomarker disease BEFREE Redundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behcet's Disease-associated HLA-B*51 Peptidome. 31092671 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 AlteredExpression disease BEFREE Furthermore, a positive correlation was observed between IL-10 serum levels and ocular manifestations in BD patients, in contrast to those of IL-17, showing no correlation with the different clinical manifestations. 31122907 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE The distinct effects of both enzymes on the HLA-B*51 peptidome provide a basis for their differential association with Behçet's disease and suggest a pathogenetic role of the B*51:01 peptidome. 31092671 2019
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 GeneticVariation disease BEFREE Genotyping of Italian patients with Behçet syndrome identified two novel ERAP1 polymorphisms using sequencing-based approach. 30742879 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE Behçet's disease was associated with HLA-A*24 and HLA-B*42 (p = 0.001) and highly associated with HLA-A*68 and B*15 and B*51 (p < 0.001). 30260727 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE This meta-analysis showed that the IL-10 - 819 C/T and - 592 C/A polymorphisms are associated with BD susceptibility, especially in Asian population. 31721090 2019
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 GeneticVariation disease BEFREE Genetic variants of ERAP1 (leading to distinct allotypes) are linked with specific autoinflammatory disorders, such as ankylosing spondylitis and Behçet's disease. 30769005 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker disease BEFREE Treg and Th17 cell frequencies and Th17 RORγt expression were significantly elevated, and IL-10 concentration in Treg cell supernatants was significantly lower in BD patients than in controls. 30601931 2019
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 GeneticVariation disease BEFREE Along with human leukocyte antigen gene encoding B*51 (HLA-B*51) and areas including the major histocompatibility complex class I, genome-wide association studies have recognized numerous other BD susceptibility genes including those encoding interleukin (IL)-10, IL-12 receptor β 2 (IL-12RB2), IL-23 receptor (IL-23R), C-C chemokine receptor 1 gene, signal transducer and activator of transcription 4 (STAT4), endoplasmic reticulum aminopeptidase (ERAP1), and genes encoding killer cell lectin-like receptor family members (KLRC4-KLRK1). 30341905 2019
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 Biomarker disease BEFREE Altered trimming of microbial and/or endogenous peptides by endoplasmic reticulum aminopeptidase 1 (ERAP1), presented by <i>HLA-B</i><sup>*</sup><i>51</i>, may play a key role in BD pathogenesis causing an alteration in T cell balance with downregulation of Tregs and expansion of Th1 and Th17. 31134098 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE Our results indicate that MICA*049, not MICA*009, is a risk factor to BD, and that is independent from HLA-B*51 in the Han Chinese cohort. 31350414 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE To our knowledge, this is the first analysis of KIR3DL1/S1 allelic variation in Behçet disease and may provide insight into the pathogenic role of <i>HLA-B*51</i> and its interaction with KIR3DL1/S1. 31405953 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Our group previously reported that HLA-A*26 is independently associated with the risk of the onset of BD apart from HLA-B*51. 30872678 2019
Entrez Id: 51752
Gene Symbol: ERAP1
ERAP1
0.700 GeneticVariation disease BEFREE This study was conducted on the two most consistently BS-associated ERAP1 polymorphisms, rs17482078 (NG_027839.1:g.35983G>A) and rs27044 (NG_027839.1:g.35997C>G) to analyse their distribution in 55 Italian BS patients and 65 ethnically matched controls (healthy controls, HC) and to test their association with BS risk. 30820838 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker disease BEFREE HBV: hepatitis B virus; HCC hepatocellular carcinoma; TNFSF10: tumor necrosis factor superfamily member 10; ATG5: autophagy-related protein 5; DNA: deoxyribonucleic acid; LDR-PCR: ligase detection reactions-polymerase chain reaction; PCR: polymerase chain reaction; SLE: systemic lupus erythematosus; BD: Behçet's disease; IL-10: interlukin-10; LPS: lipopolysaccharide; PBMC: peripheral blood mononuclear cells; CWP: coal workers' pneumoconiosis; TNF-α: tumor necrosis factor-α. 30907204 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE In conclusion, two peptides that had high affinity to HLA-B*51:01 in computerized binding prediction showed significantly higher response in HLA-B*51:01-positive patients with BD, indicating the usefulness of computerized simulations for identifying autoreactive peptides to HLAs. 31513650 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Our findings suggest that gene-gene interactions between HLA-B*51 and ERAP1 variants is important for BD development, however, ERAP1 variants which interact with HLA-B*51 may differ among disease phenotypes or populations. 30514861 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE Therefore, the goal of this study was to measure the correlation of the IL-10 gene polymorphisms with the susceptibility to Behçet's disease compared with the control group in the Azeri population and to determine the expression of this gene in the two groups. 29294320 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 AlteredExpression disease BEFREE We revealed that hypermethylation of promoter region was the principal defect for the IL-10 mRNA low expression in patients with Behçet's disease. 29719061 2018
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 Biomarker disease BEFREE In fact, the HLA-B*51 is inherited as part of extended HLA haplotypes which are well preserved in patients with BD. 30252881 2018
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.700 GeneticVariation disease BEFREE Among these variants, the genetic variant associated with Behçet's disease in the <i>HLA-B</i>/<i>MICA</i> region, which tags <i>HLA-B*51</i>, is within novel long intergenic noncoding RNA transcripts that are exclusively expressed from the haplotype with the protective but not the disease risk allele. 29311362 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation disease BEFREE The objective of the present study was to clarify the pathological roles of CCR1 and IL10 loci identified by previous BD genome-wide association studies (GWASs). 29895319 2018