Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 AlteredExpression disease BEFREE Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression. 28583708 2020
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 Biomarker disease BEFREE Reelin (RELN) is identified as a risk gene for major psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BPD). 26637325 2016
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 AlteredExpression disease BEFREE Schizophrenia (SZ) and bipolar disorder (BPD) patients show a downregulation of GAD67, reelin (RELN), brain-derived neurotrophic factor (BDNF), and other genes expressed in telencephalic GABAergic and glutamatergic neurons. 25364290 2014
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 Biomarker disease PSYGENET Schizophrenia (SZ) and bipolar disorder (BPD) patients show a downregulation of GAD67, reelin (RELN), brain-derived neurotrophic factor (BDNF), and other genes expressed in telencephalic GABAergic and glutamatergic neurons. 25364290 2014
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 Biomarker disease PSYGENET A number of neuropsychiatric disorders including autism, schizophrenia, bipolar disorder, major depression, Alzheimer's disease and lissencephaly share a common feature of abnormal Reelin expression in the brain. 22981949 2013
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 Biomarker disease PSYGENET We evaluated whether an RELN gene variant, rs362719, which has been associated with increased susceptibility to bipolar disorder, is also associated with susceptibility to schizophrenia. 21863557 2011
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 Biomarker disease PSYGENET Previous results have revealed that reelin levels are decreased in post-mortem hippocampal tissue from patients with schizophrenia, bipolar disorder and depression, and also in an animal model of depression. 20849864 2011
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 GeneticVariation disease BEFREE We evaluated whether an RELN gene variant, rs362719, which has been associated with increased susceptibility to bipolar disorder, is also associated with susceptibility to schizophrenia. 21863557 2011
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 Biomarker disease PSYGENET Recent studies have shown that Reelin, an extracellular protein that is critical for neuronal development, is reduced in schizophrenia and bipolar disorder patients. 21814183 2011
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 AlteredExpression disease BEFREE Post-mortem studies have shown lower Reelin protein levels in the brains of patients with schizophrenia and bipolar disorder (BP) compared with controls. 19691043 2010
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 Biomarker disease CTD_human We employed SDS-PAGE and Western blotting to measure levels of GAD isomers 65 and 67 kDa and Reelin isoforms 410-, 330- and 180-kDa proteins as well as beta-actin in cerebellum of subjects with schizophrenia, bipolar disorder and major depression vs. controls (N = 15 per group). 15560956 2005
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 Biomarker disease BEFREE This gene's protein Reelin, which is necessary for neuronal migration and synaptogenesis, is reduced in schizophrenia and bipolar disorder, suggesting hypermethylation of the promoter region in these disorders. 15108180 2004
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 Biomarker disease CTD_human In addition, reelin protein in the molecular layer of the dentate gyrus was decreased in schizophrenia, bipolar disorder, and depression at the trend level of statistical significance (P=0.065). 14708030 2004
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 Biomarker disease CTD_human We present new immunocytochemical evidence showing reductions in Reelin expression in hippocampus of subjects with schizophrenia, bipolar disorder and major depression and confirm recent reports documenting a similar deficit involving Reelin expression in brains of subjects with schizophrenia and bipolar disorder. 11126396 2000
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.570 AlteredExpression disease BEFREE A research strategy directed toward identifying specific neurochemical markers operative in the etiopathology of psychotic disorders lead to the identification of a downregulation (30-50%) of Reln and glutamic acid decarboxylase 67(GAD67) expression in prefrontal cortex and other brain areas of schizoprenia and bipolar disorder patients with psychosis. 11059795 2000