Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 GeneticVariation disease BEFREE In secondary analyses, HTR2A (rs643627, p = 0.002) and CHL1 (rs4003413, p = 0.002) were found associated with risk for BD, HOMER1 (rs6872497, p = 0.002) with lifetime history of suicide attempt in patients, and RORA with early onset and presence of psychotic features in BD. 30178121 2018
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 Biomarker disease PSYGENET Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia. 24962835 2014
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 GeneticVariation disease BEFREE Ongoing research has identified a region of the HTR2A promoter that has been associated with a number of medical outcomes in adults and infants, including bipolar disorder, schizophrenia, chronic fatigue syndrome, borderline personality disorder, suicidality, and neurobehavioral outcomes. 25043477 2014
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 Biomarker disease PSYGENET Ongoing research has identified a region of the HTR2A promoter that has been associated with a number of medical outcomes in adults and infants, including bipolar disorder, schizophrenia, chronic fatigue syndrome, borderline personality disorder, suicidality, and neurobehavioral outcomes. 25043477 2014
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 Biomarker disease PSYGENET We found that the association of the HTR2A -1438A/G polymorphism with SZ depends on the ethnic origin of the study population, and this genetic variant does not modify the susceptibility to BD or MDD.© 2013 Wiley Periodicals, Inc. 23404241 2013
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 GeneticVariation disease BEFREE We found that the association of the HTR2A -1438A/G polymorphism with SZ depends on the ethnic origin of the study population, and this genetic variant does not modify the susceptibility to BD or MDD. 23404241 2013
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 Biomarker disease PSYGENET Logistic regression analysis showed a significant effect of the ALDH2 and the 5-HT2A-A1438G polymorphisms, and a significant interaction effect for the A/G genotypes of the 5-HT2A-A1438G polymorphism and the ALDH2*1*1 genotypes (p=0.004) discriminated between bipolar-I patients and controls without bipolar disorder. 22564712 2012
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 Biomarker disease PSYGENET Furthermore, epigenetic down-regulation of HTR2A was associated with early age of disease onset in SCZ and BD. 21550210 2011
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 GeneticVariation disease BEFREE Cytosine methylation of HTR2A at T102C polymorphic site in DNA derived from the saliva can potentially be used as a diagnostic, prognostic, and/or therapeutic biomarker in SCZ and BD. 21598376 2011
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 AlteredExpression disease BEFREE Furthermore, epigenetic down-regulation of HTR2A was associated with early age of disease onset in SCZ and BD. 21550210 2011
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 Biomarker disease BEFREE We did not detect significant an association of HTR2A with MDD and BP in allele/genotype-wise or haplotype-wise analysis. 19428704 2009
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 Biomarker disease BEFREE Polymorphisms within the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes are being studied for association with lithium prophylaxis in a sample of 155 Sardinian unrelated probands affected by bipolar disorder (BP). 19647327 2009
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 GeneticVariation disease BEFREE We previously reported linkage evidence for a bipolar affective disorder susceptibility locus on chromosome 13q, which harbours HTR2A, thus making the gene both a positional and functional candidate. 19584773 2009
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 GeneticVariation disease BEFREE Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder. 17221840 2007
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 Biomarker disease BEFREE The ability of atypical antipsychotics to block both 5-HT(2) and D(2) receptors and downregulate 5-HT(2) receptors may explain how these drugs treat both the depressive and manic symptoms of bipolar disorder. 15948763 2005
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 Biomarker disease RGD The genetic association database. 15118671 2004
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 AlteredExpression disease BEFREE Our study used in situ hybridization to quantify 5-HT(1A), 5-HT(1B), and 5-HT(2A) mRNA levels in the hippocampus (HC) and 5-HT(1A) and 5-HT(2A) mRNA levels in the dorsolateral prefrontal cortex (DLPFC) of subjects with a history of major depression disorder (MDD), bipolar disorder (BPD), schizophrenia, and a normal comparison group (15 subjects per group). 14744462 2004
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 Biomarker disease CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030 2004
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 GeneticVariation disease BEFREE Many studies investigated the association between MDD and BD with the 5-HT2A 102 T/C, the 5-HTT promoter 44 bp insertion/deletion and the intron 2 VNTR polymorphisms, and thus, these could be pooled using meta-analytic techniques. 12851635 2003
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 GeneticVariation disease BEFREE The association detected in this study suggests that the 5-HT(2A) receptor gene may play a role in the genetic susceptibility to bipolar disorder, through a specific subgroup of bipolar type I patients with lower risk of suicidal behavior. 11983190 2002
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 GeneticVariation disease BEFREE No significant transmission disequilibrium between the alleles of 5-HT2A and BP was found. 12622403 2002
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 GeneticVariation disease BEFREE Although further studies are necessary, these results in a Korean population suggest that -1438A/G polymorphism of 5-HT2A receptor gene promoter may be causally related to the development of bipolar disorder. 11702051 2001
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 GeneticVariation disease BEFREE Despite the limited sample size, these results exclude a major effect of the 5-HTR2a polymorphism on bipolar disorder and HA personality trait but not a minor effect. 10898915 2000
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 GeneticVariation disease BEFREE These results indicate that, in our sample, the 5-HT2A receptor polymorphism studied is unlikely to play a major role in the genetic susceptibility to BPAD.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:136-140, 2000. 10893484 2000
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.800 Biomarker disease BEFREE The lack of association suggests that HTR2A is not a major risk factor for bipolar affective disorder. 9341875 1997