Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.520 Biomarker disease CTD_human Serotonin transporter linked promoter (polymorphism) in the serotonin transporter gene may be associated with antidepressant-induced mania in bipolar disorder. 16395126 2006
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.520 Biomarker disease CTD_human Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. 11772685 2002
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.520 Biomarker disease PSYGENET The aim of this study was to investigate the role of the SLC6A4 variants in the pathogenesis of antidepressant-induced mania in BP. 11386982 2001
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.520 Biomarker disease BEFREE The serotonin transporter (5-HTT) is the selective site of action of most proserotonergic compounds used to treat bipolar depression. 11386982 2001
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.520 GeneticVariation disease BEFREE However, further studies focusing on the role of the 5HTT gene in predicting the response to SSRIs in BP patients might be worthwhile. 10898918 2000
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.520 Biomarker disease PSYGENET However, further studies focusing on the role of the 5HTT gene in predicting the response to SSRIs in BP patients might be worthwhile. 10898918 2000
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.510 GeneticVariation disease BEFREE Serotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression. 18801406 2009
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.510 Biomarker disease PSYGENET The expression of COMT does not appear to be altered in the cerebellum of individuals suffering from schizophrenia, bipolar disorder or depression, but does appear to be influenced by single nucleotide polymorphisms within the gene. 16483362 2006
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.510 Biomarker disease CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030 2005
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.510 Biomarker disease PSYGENET Associations have also been reported between the catechol-O-methyltransferase (COMT) gene and both OCD and bipolar depression. 12815746 2004
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.510 GeneticVariation disease BEFREE Associations have also been reported between the catechol-O-methyltransferase (COMT) gene and both OCD and bipolar depression. 12815746 2004
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
0.510 Biomarker disease RGD The genetic association database. 15118671 2004
Entrez Id: 1312
Gene Symbol: COMT
COMT
0.510 Biomarker disease CTD_human Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. 11772685 2002
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.500 Biomarker disease CTD_human Regionally specific changes in levels of cortical S100beta in bipolar 1 disorder but not schizophrenia. 16476148 2006
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.500 Biomarker disease RGD Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain. 15581912 2005
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.500 Biomarker disease CTD_human Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain. 15581912 2005
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.320 Biomarker disease BEFREE The effect of childhood trauma on serum BDNF in bipolar depression is modulated by the serotonin promoter genotype. 28754344 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.320 Biomarker disease BEFREE Further evidence supporting the influence of brain-derived neurotrophic factor on the outcome of bipolar depression: independent effect of brain-derived neurotrophic factor and harm avoidance. 20142305 2011
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.320 Biomarker disease PSYGENET This is the first study that associated 5-HT1A receptor promoter gene variants with stressors preceding the need of hospitalization for bipolar depression. 21397953 2011
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.320 GeneticVariation disease BEFREE Association of the C(-1019)G 5-HT1A promoter polymorphism with exposure to stressors preceding hospitalization for bipolar depression. 21397953 2011
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.320 Biomarker disease PSYGENET No difference in 5-HT1A BP(F) between BD and control females may reflect greater effect of prior antidepressant exposure in BD females. 19278673 2009
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.320 Biomarker disease BEFREE No difference in 5-HT1A BP(F) between BD and control females may reflect greater effect of prior antidepressant exposure in BD females. 19278673 2009
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.320 Biomarker disease CTD_human Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients. 19018715 2009
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.320 Biomarker disease CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030 2005
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
0.310 GeneticVariation disease BEFREE Glycogen synthase kinase 3 beta gene structural variants as possible risk factors of bipolar depression. 24677591 2014