Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE A simple and fast method for the simultaneous detection of nine fibroblast growth factor receptor 3 mutations in bladder cancer and voided urine. 16278395 2005
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Several genetic changes may occur in bladder cancer, but activating mutations in the fibroblast growth factor receptor 3 (FGFR3) genes are the most common and most specific genetic abnormality in bladder cancer. 20822928 2013
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE PATIENT SUMMARY: We propose that APOBEC-mediated mutagenesis can generate clinically relevant driver mutations even within suboptimal motifs, such as in the case of FGFR3 S249C, one of the most common mutations in bladder cancer. 30975452 2019
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE The GSE41035 dataset downloaded from Gene Expression Omnibus was used to identify the differentially expressed genes (DEGs) between bladder cancer cell line RT112 with or without depletion of FGFR3, and gene ontology enrichment analysis was performed. 28320388 2017
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC. 20348956 2010
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE TP53 and FGFR3 Gene Mutation Assessment in Urine: Pilot Study for Bladder Cancer Diagnosis. 26254388 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE An example of a TM domain pathogenic mutation is the Ala391-->Glu mutation in fibroblast growth factor receptor 3 (FGFR3), linked to Crouzon syndrome with acanthosis nigricans, as well as to bladder cancer. 16384584 2006
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Incidence of fibroblast growth factor receptor 3 gene (FGFR3) A248C, S249C, G372C, and T375C mutations in bladder cancer. 21264819 2011
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Silencing or inhibition of mutant FGFR3 in bladder cancer cell lines is associated with decreased malignant potential, confirming its important driver role in UC. 30952872 2019
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE The two most important developments are the identification of a mutation in the fibroblast growth factor receptor 3 gene in more than 50% of urothelial carcinomas and the discovery of cDNA profiles characteristic of different subsets of bladder cancer. 19031931 2009
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bladder cancer carrying the FGFR3 gene mutation along with up-regulation of p27/Kip1 and G1/G0 arrest. 19955487 2010
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE FGFR3 analyses did not reveal any mutation in the urothelium from neither the control group nor the bladder cancer group. 19621447 2009
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE The Diagnostic and Prognostic Performance of Urinary FGFR3 Mutation Analysis in Bladder Cancer Surveillance: A Prospective Multicenter Study. 26364695 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE FGFR3 and Tp53 mutations have been proposed as defining two alternative pathways in the pathogenesis of transitional bladder cancer. 16061860 2005
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE We carried out a meta-analysis of published findings for FGFR3 and TP53 mutations in bladder cancer (535 tumours, 6 publications) and additional unpublished data for 382 tumours. 23272046 2012
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Somatic FGFR3 Mutations Distinguish a Subgroup of Muscle-Invasive Bladder Cancers with Response to Neoadjuvant Chemotherapy. 29941343 2018
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Usefulness of droplet digital PCR and Sanger sequencing for detection of FGFR3 mutation in bladder cancer. 31377167 2019
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Recent developments in the field of molecular mutational pathway analyses based on next generation sequencing technology together with classic data derived from the description of mutations in the FGFR3 (fibroblast growth factor receptor 3) gene, mutations on TP53 gene, and cDNA technology profiling data gives support to a differentiated taxonomy of bladder cancer. 25654736 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE We analyzed the possible prognostic value of the recently discovered fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer. 11245416 2001
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE The detection of FGFR3 mutations in FUH further supports the role of this lesion as precursor of papillary bladder cancer. 16570285 2006
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE When we examined detailed data on a prevalent occupational exposure associated with increased bladder cancer risk, straight metalworking fluids, we also observed statistically significant additive interaction for rs798766 (TMEM129-TACC3-FGFR3, P interaction = .02), with the interaction more apparent in patients with tumors positive for FGFR3 expression.All statistical tests were two-sided. 26374428 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Massively parallel sequencing of sperm DNA showed that levels of the FGFR3 mutation increase with paternal age and that the mutation spectrum at the Lys650 codon is similar to that observed in bladder cancer. 19855393 2009
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE In bladder carcinoma, we recently identified FGFR3 mutations in 41% of tumours, making this the most frequently mutated putative oncogene identified in bladder cancer to date. 11466624 2001
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Search terms included 'FGFR3 genomic alterations' and 'urothelial cancer' or 'bladder cancer'. 27271022 2016
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Therefore, we looked for FGFR3 mutations in these two animal models of bladder cancer. 15690367 2005