Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE Liquid Biopsy Analysis of FGFR3 and PIK3CA Hotspot Mutations for Disease Surveillance in Bladder Cancer. 28069289 2018
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE Exploring the FGFR3-related oncogenic mechanism in bladder cancer using bioinformatics strategy. 28320388 2017
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE The Diagnostic and Prognostic Performance of Urinary FGFR3 Mutation Analysis in Bladder Cancer Surveillance: A Prospective Multicenter Study. 26364695 2016
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 AlteredExpression disease BEFREE The role of mutations and overexpression of the fibroblast growth factor receptor-3 in bladder cancer. 26542242 2016
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE In MGH-U3 bladder cancer xenografts, which contain both AKT1(E17K) and FGFR3(Y373C) mutations, AZD5363 monotherapy did not significantly reduce tumor growth, but tumor regression was observed in combination with the FGFR inhibitor AZD4547. 26351323 2016
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE This is a comprehensive genomic characterization of 40 urothelial bladder carcinoma (UBC) cell lines including information on origin, mutation status of genes implicated in bladder cancer (FGFR3, PIK3CA, TP53, and RAS), copy number alterations assessed using high density SNP arrays, uniparental disomy (UPD) events, and gene expression. 25997541 2016
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE FGFR3 mutations are common in low-grade BC, while TP53 mutation or loss of RB1 is associated with muscle-invasive BC. 26924873 2016
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Analysing only previously reported point mutations, TERT mutations were found in 55% of patients with bladder cancer (independent of stage), FGFR3 mutations in 30% of patients with bladder cancer, PIK3CA in 14% and TP53 mutations in 12% of patients with bladder cancer. 26901314 2016
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE TP53 and FGFR3 Gene Mutation Assessment in Urine: Pilot Study for Bladder Cancer Diagnosis. 26254388 2016
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer. 25809917 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE Activating point mutations and protein overexpression of fibroblast growth factor receptors (FGFRs), especially FGFR3, are frequent events in bladder cancer. 24898159 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Silencing of endogenous mutant FGFR3 in bladder cancer cells induced converse changes in transcript levels of CDH16, PLAU, MMP10, EPCAM, TNC, and HAS3, confirming them as downstream gene targets of mutant FGFR3. 25223521 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 CausalMutation disease CLINVAR Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. 25741868 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE When we examined detailed data on a prevalent occupational exposure associated with increased bladder cancer risk, straight metalworking fluids, we also observed statistically significant additive interaction for rs798766 (TMEM129-TACC3-FGFR3, P interaction = .02), with the interaction more apparent in patients with tumors positive for FGFR3 expression.All statistical tests were two-sided. 26374428 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism. 24784839 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE TERT promoter mutations and TERT mRNA but not FGFR3 mutations are urinary biomarkers in Han Chinese patients with urothelial bladder cancer. 25657201 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE The development and progression of BC rely on a very complex signaling network that involves many different receptors aside from FGFR3 and VEGFR2. 25284004 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Recent developments in the field of molecular mutational pathway analyses based on next generation sequencing technology together with classic data derived from the description of mutations in the FGFR3 (fibroblast growth factor receptor 3) gene, mutations on TP53 gene, and cDNA technology profiling data gives support to a differentiated taxonomy of bladder cancer. 25654736 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE MMP-1 and Pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer. 25326231 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 PosttranslationalModification disease BEFREE Fibroblast growth factor receptor 3 interacts with and activates TGFβ-activated kinase 1 tyrosine phosphorylation and NFκB signaling in multiple myeloma and bladder cancer. 24466111 2014
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Furthermore, distinct methylation patterns have been identified between non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC), as well as between FGFR3-mutant and wild-type tumours. 23628807 2014
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease CTD_human Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. 24121792 2014
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE Two bladder cancer cell lines that harbor FGFR3 fusion proteins exhibited enhanced susceptibility to pharmacologic inhibition in vitro and in vivo. 23558953 2014
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE FGFR3 mutations, but not FGFR3 expression and FGFR3 copy-number variations, are associated with favourable non-muscle invasive bladder cancer. 24880661 2014
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE This study indicates that the FGFR3 urine assay, which was originally developed to monitor bladder cancer, is also a useful tool for diagnosing upper urinary tract cancer in a real-life setting. 22873290 2013