| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.480 | AlteredExpression | group | BEFREE | Collectively, our findings indicate a pro-oncogenic role of LOC441204 in tumor cell growth through activation of the β-catenin/p21/cdk4 cascade to act as a potential diagnostic marker or therapeutic target in brain tumor. | 28717243 | 2017 | ||||
|
0.480 | Biomarker | group | BEFREE | The Wnt/beta catenin pathway has been highlighted as an important player of brain tumors aggressiveness and resistance to therapies. | 27613837 | 2016 | ||||
|
0.480 | Biomarker | group | BEFREE | Our findings provide novel information about p53 involvement in meningeal brain tumours and reveal the complex relationship between Wnt and p53 signalling, they suggest an important role for beta-catenin in these tumours. | 27292269 | 2016 | ||||
|
0.480 | GeneticVariation | group | CLINVAR | Prospective enterprise-level molecular genotyping of a cohort of cancer patients. | 25157968 | 2014 | ||||
|
0.480 | Biomarker | group | BEFREE | Changes of AXIN-1 and beta-catenin in neuroepithelial brain tumors. | 19633924 | 2010 | ||||
|
0.480 | Biomarker | group | BEFREE | These results indicate that the mutation of exon 3 of the CTNNB1 gene in brain tumours may be a rare event and yet may be required for a small subset of human metastatic brain tumours. | 19582367 | 2009 | ||||
|
0.480 | Biomarker | group | BEFREE | Genetic changes of CDH1, APC, and CTNNB1 found in human brain tumors. | 17905526 | 2007 | ||||
|
0.480 | Biomarker | group | BEFREE | Others have also associated the virus to the induction of colon cancer and aneuploid brain tumors by producing a highly tumorigenic protein named T antigen (TAg), which binds to beta-catenin and inactivates key proteins such as p53. | 14612521 | 2003 | ||||
|
0.480 | GeneticVariation | group | BEFREE | There was no apparent difference of beta-catenin expression profile in brain tumors; however, the sequencing data of beta-catenin showed two mutations on speculative phosphorylation sites, S73F and S23G in astrocytoma. | 12049819 | 2002 | ||||
|
0.480 | CausalMutation | group | CGI |