Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Extra domain A-containing fibronectin expression in Spin90-deficient fibroblasts mediates cancer-stroma interaction and promotes breast cancer progression. 31637720 2020
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE The extracellular matrix protein fibronectin (FN) facilitates tumorigenesis and the development of breast cancer. 31000696 2019
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE We recently showed that fibronectin (FN) leads to Tam resistance and selection of breast cancer stem cells. 31812165 2019
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Fibronectin levels were higher (P = 0.014) in patients infected with HCV than noninfected BC patients. 29285674 2018
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Using publicly available clinical data, we observed that high FN expression was associated with poor prognosis in patients with breast cancer. 29628980 2018
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Enhanced antitumor and anti-metastasis efficacy against aggressive breast cancer with a fibronectin-targeting liposomal doxorubicin. 29277681 2018
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Autocrine Fibronectin Inhibits Breast Cancer Metastasis. 29934326 2018
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE In addition, overexpression of wild-type p53 markedly decreased the level of FN expression in p53-mutant breast cancer cells. 28765903 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Fibronectin induces epithelial-mesenchymal transition in human breast cancer MCF-7 cells via activation of calpain. 28521486 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE EDB Fibronectin-Specific SPECT Probe <sup>99m</sup>Tc-HYNIC-ZD2 for Breast Cancer Detection. 30023665 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 GeneticVariation disease BEFREE We conclude that the FZD6-fibronectin actin axis identified in our study could be exploited for drug development in highly metastatic forms of breast cancer, such as TNBC.© 2016 The Authors. 27859262 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Subsequently, a large panel of breast cancer cell lines was used to validate that hypoxia induces the expression of integrins that bind to collagen (ITGA1, ITGA11, ITGB1) and fibronectin (ITGA5, ITGB1). 28213554 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE A drug-delivery strategy for overcoming drug resistance in breast cancer through targeting of oncofetal fibronectin. 27769887 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE In particular, we found that TGFβ-induced expression of fibronectin plays a central role in TGFβ-mediated breast cancer stemness. 28054666 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Taken together, these results demonstrate that FN expression is upregulated through the PI-3K/Akt pathway in tamoxifen-resistant breast cancer cells.[BMB Reports 2017; 50(12): 615-620]. 28855026 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE We found an overall increase in these processes with increasing concentration on both laminin and fibronectin gradients for a series of ovarian and breast cancer lines. 29177019 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE MENA(INV) and FN levels were correlated in two breast cancer cohorts, and high levels of MENA(INV) were significantly associated with increased tumor recurrence as well as decreased patient survival. 26811325 2016
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and β1-integrin signaling pathway in tumor cells. 25990368 2015
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Aberrant FN expression is associated with poor prognoses in various types of cancer, including breast cancer. 25743092 2015
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Previous studies have shown that FN can be degraded into fragments by MMP-9 in vitro; MMP-9 expression is upregulated in breast cancer, therefore, the role of degraded FN in breast cancer progression needs to be investigated. 26134759 2015
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Targeted Therapy for Breast Cancer Stem Cells by Liposomal Delivery of siRNA against Fibronectin EDB. 26097122 2015
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE We show that GPNMB enhances breast cancer cell adhesion to fibronectin, increases α5β1 expression and associates with this receptor through its RGD motif. 25772243 2015
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE It is known that fibronectin is capable of promoting the expression of MMP-2 in MCF7 breast cancer cells in culture. 25208219 2014
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Using this breast cancer (BC) model, we find that in addition to EGF, adhesion to fibronectin (FN) activates signal transducer and activator of transcription 3 (STAT3) through EGFR-dependent and -independent mechanisms. 23653350 2013
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease CTD_human MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro. 24014025 2013