Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 Biomarker disease BEFREE Combined detection of GATA3 and E-cadherin is of great significance in the diagnosis and treatment of breast cancer, and it is expected to become an effective indicator for the diagnosis of breast cancer in the future. 31424658 2020
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 GeneticVariation disease BEFREE Breast cancer mutation in GATA3 zinc finger 1 induces conformational changes leading to the closer binding of ZnFn2 with a wrapping architecture. 31107186 2020
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 Biomarker disease BEFREE TTF-1 and napsin A for lung adenocarcinoma, p40 for squamous lung cancer, GATA3 and mammaglobin for breast cancer, or synaptophysin and chromogranin A for neuroendocrine tumors). 30354850 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 Biomarker disease BEFREE Presence of CK7, GATA 3, and E cadherin tends to increase in mismatch repair deficient breast cancer. 30149959 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 AlteredExpression disease BEFREE Mechanistically, LSD1 interacts with GATA3, a key luminal-specific transcription factor (TF), and their common target genes are highly related to breast cancer. 31409898 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 Biomarker disease BEFREE Pulmonary metastases of breast cancer were positive for GATA3 in 93% and CK7 in 78% of the cases, whereas 15% expressed CK5. 30389437 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 Biomarker disease BEFREE Through this study, we identified possible GATA3-correlated genes and core pathways that play an important role, which requires further investigation in breast cancer. 30872657 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 GeneticVariation disease BEFREE The genomic landscape of MBC to some extent recapitulated that of smFBC, with recurrent PIK3CA (36%) and GATA3 (15%) somatic mutations, and with 40% of the most frequently amplified genes overlapping between both sexes. 31340200 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 AlteredExpression disease BEFREE In this study, the diagnostic utility of a panel of SOX10, GATA3, and androgen receptor (AR) in MBC negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 was evaluated and compared with the expression of these markers in the matched primary breast cancer. 30468800 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 AlteredExpression disease BEFREE We discovered a role for GATA3 in suppressing epithelial-to-mesenchymal transition (EMT) in breast cancer by activating miR-455-3p expression. 31492753 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 AlteredExpression disease BEFREE Heterozygous mutations in the transcription factor GATA3 are identified in 10-15% of all breast cancer cases. 31218575 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 GeneticVariation disease BEFREE We sought to determine the prognostic and predictive roles of GATA3 genotypes for breast cancer. 30928413 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 Biomarker disease BEFREE GATA3 loss is associated with aggressive breast cancer development, but the mechanism by which breast cancer is affected by the loss of GATA3 function remains unclear. 31685800 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 Biomarker disease BEFREE Clinicopathological characterization of CK7 negative breast cancer has not been addressed previously and similar studies on GATA3 negative tumors are limited. 31718619 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 AlteredExpression disease BEFREE Here, we demonstrate that GATA3 reduces the ATP level in the breast cancer microenvironment and inhibits breast cancer metastasis by up-regulating ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3). 31754326 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 Biomarker disease BEFREE Application to 213 phenotypes and 1,544 TF binding datasets identified 2,264 relationships between hundreds of TFs and 94 phenotypes, including androgen receptor in prostate cancer and GATA3 in breast cancer. 29662164 2018
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 AlteredExpression disease BEFREE GATA3 is a master regulator that drives mammary epithelial cell differentiation, and the suppression of GATA3 expression is associated with the development of aggressive breast cancer. 29510139 2018
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 Biomarker disease BEFREE Furthermore, we demonstrated that FBXW7α inhibits breast cancer cells survival through destabilizing GATA3, and the expression level of FBXW7α is negatively correlated with that of GATA3 in breast cancer samples. 28722108 2018
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 AlteredExpression disease BEFREE The histopathologic features and the expression of GATA3, cytokeratin (CK)7, mammaglobin staining and estrogen and progesterone receptors led to a diagnosis of breast cancer originating from the ectopic mammary tissue in the vulva. 30125424 2018
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 GeneticVariation disease BEFREE Heterozygous GATA3 mutations occur in up to 15% of estrogen receptor (ER)-positive breast tumors and have been proposed to be null alleles resulting in haploinsufficiency; however, the mutation spectrum of GATA3 in breast cancer is in sharp contrast to that found in HDR syndrome, a true GATA3 haploinsufficiency disease. 30061207 2018
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 Biomarker disease BEFREE Even though GATA3 expression has been reported in many benign and malignant adnexal tumors (mostly of sebaceous, follicular, and apocrine differentiation), as well as in many other neoplasms, GATA3 staining to differentiate PCACC from skin breast cancer metastasis has a high negative predictive value. 29431200 2018
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 Biomarker disease BEFREE Kaplan-Meier survival analyses showed that ER+/progesterone receptor (PgR)+ and lower grade BC patients with relatively high GATA3 had better clinical overall survival (OS). 29902578 2018
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 Biomarker disease BEFREE Despite numerous studies on the utility of GATA-3 as breast cancer marker, its comparison with other breast markers, its concordance between primary and metastatic tumors and its expression in primary cancers from sites with frequent breast metastases remains unclear. 29340880 2018
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 AlteredExpression disease BEFREE Androgen receptor expression is strongly correlated with GATA3 in breast cancer, particularly in tumors with lobular morphology. 29408697 2018
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.600 AlteredExpression disease BEFREE Although GATA3 levels remained unaltered between primary breast cancer and pleural metastases, FOXA1 levels were reduced exclusively in metastases of patients who received endocrine therapies in the adjuvant setting, even though ERα was still expressed. 29972720 2018