Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GenomicAlterations group CGI
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 CausalMutation group CGI
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE <b> Kim and colleagues identify necrotic debris as a macropinocytic cargo in PTEN-deficient prostate cancer cells, which is catabolized to generate the nutrients and biomass necessary to support tumor cell growth and metabolism in nutrient-limiting conditions.<i>Cancer Discov; 8(7); 800-2. 29967075 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 PosttranslationalModification group BEFREE (Cancer Cell 35:504-518, 2019) reported that the phosphorylation of phosphatase and tensin homolog (PTEN) at tyrosine 240 (pY240-PTEN) promotes the radioresistance of human glioma cells. 31025173 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE Cancer cells in which the PTEN lipid phosphatase gene is deleted have constitutively activated phosphatidylinositol 3-kinase (PI3K)-dependent signaling and require activation of this pathway for survival. 12714585 2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE Cancer stem cells are known to be controlled by pathways that are dormant in normal adult cells, for example, PTEN, which is a negative regulator of transcription factor STAT3. 29138265 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation group BEFREE Cancer gene-panel testing identifies two loss-of-function alleles in PALB2 and PTEN. 29430632 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE PTEN is a recently identified tumor suppressor inactivated in a variety of cancers such as glioblastoma and endometrial and prostate carcinoma. 10468583 1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE PTEN gene and integrin signaling in cancer. 10547389 1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation group BEFREE PTEN mutations have been described in several types of human cancer. 11751500 2001
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation group BEFREE PTEN is mutated at high frequency in many primary human cancers and several familial cancer predisposition disorders. 11997518 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression group BEFREE PTEN expression in OSCC was related to the malignancy grade (P < 0.0005). 12224530 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE PTEN is a recently identified tumour suppressor inactivated in a wide variety of human cancers, including endometrial cancers. 12405911 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE PTEN is a candidate tumor suppressor gene in a variety of malignant tumors, including renal cell carcinoma (RCC). 14598361 2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE PTEN was deleted from 16% in the cancer tissues and the deletion was not related to the smoking status of patients (P > 0.05). 16061856 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation group BEFREE PTEN mutations in clinical cancer specimens can easily be recorded but mono- or bi-allelic gene deletions are often difficult to assess. 16402365 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) encodes a tumor-suppressor phosphatase frequently mutated in both sporadic and heritable forms of human cancer. 17033968 2006
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE PTEN and the PI3-kinase pathway in cancer. 18767981 2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression group BEFREE PTEN expression is increased by p53, and its function is blunted in several malignancies. 19173293 2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 PosttranslationalModification group BEFREE PTEN activity is lost by mutations, deletions or promoter methylation at high frequency in many primary and metastatic human cancers, and some germline mutations of PTEN are found in several familial cancer predisposition syndromes. 20214616 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation group BEFREE PTEN mutations/deletion or low PTEN expression are also associated with diverse liver malignancies, suggesting a critical role for PTEN in hepatic cancers. 20460918 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE PTEN in liver diseases and cancer. 20872961 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE PTEN is among the most frequently inactivated tumour suppressor genes in sporadic cancer. 21430697 2011
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression group BEFREE PTEN expression negative CRC were not homogenous, as proximal cancers were associated with a more advanced Dukes' stage and poor differentiation, whereas distal cancers were associated with earlier Dukes' stage. 21473780 2011
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE PTEN is an important tumor suppressor, whereas the involvement of SHIP2 in cancer has been proposed based essentially on cell line studies. 21757001 2011