Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 CausalMutation group CGI
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE <b> Khan and colleagues demonstrate how serial blood-based liquid biopsies integrated with imaging and mathematical modeling can accurately "forecast" the time to treatment failure in patients with metastatic colorectal cancer treated with EGFR blockade, by early detection of molecular alterations associated with drug resistance in cell-free DNA.<i>Cancer Discov; 8(10); 1213-5. 30279194 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression group BEFREE <b>Background:</b> Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor which levels was shown to have a tight coherence with various types of cancer. 31031857 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE <b>Purpose:</b> This study evaluates the cytotoxicity of AuNPs coated with polyallylamine (AuNPs-PAA) and conjugated or not to the epidermal growth factor receptor (EGFR)-targeting antibody Cetuximab (AuNPs-PAA-Ctxb) in normal human kidney (HK-2), liver (THLE-2) and microvascular endothelial (TIME) cells, and compares it with two cancer cell lines that are EGFR-overexpressing (A431) or EGFR-negative (MDA-MB-453). 31371943 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE <i>EGFR</i> mutations in cfDNA, both the activating mutation and <i>EGFR</i> T790M, became undetectable in most patients in the setting of clinical response and reemerged upon disease progression.<b>Conclusions:</b> ASP8273 was well tolerated and promoted antitumor activity in patients with <i>EGFR</i>-mutant lung cancer with disease progression on prior EGFR TKI therapy.<i>Clin Cancer Res; 23(24); 7467-73.©2017 AACR</i>. 28954786 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE (1) The epidermal growth factor receptor (EGFR) has been identified as a therapeutic target for a multitude of malignancies, including mCRC. 24424112 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE -The National Cancer Care Network and the combined College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology guidelines indicate that all lung adenocarcinomas (ADCs) should be tested for epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements. 27552093 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE 4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment. 31492173 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression group BEFREE Cancer tissue show significantly lower expression of HER1 and HER3, and higher expression of HER4, amphiregulin, TGF-alpha and HB-EGF compared to premenopausal endometrium; no difference is seen in HER2. 16962163 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Cancer stem-like cells (CSC) are thought to play a pivotal role in tumor regeneration and appear to be influenced by the EGFR-pathway. 22483783 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Cancer-specific survival was calculated by univariate and multivariate analyses, and progression-free survival (PFS) during treatment with EGFR-targeting agents was also evaluated. 24098024 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Cancer molecular heterogeneity might explain the variable response of EGFR mutant lung adenocarcinomas to tyrosine kinase inhibitors (TKIs). 25904052 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Cancer resistance to therapies against the EGFR-RAS-RAF pathway: The role of MEK. 28073102 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Cancer-associated inflammation develops resistance to the epidermal growth-factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancers (NSCLCs) harboring oncogenic EGFR mutations. 28115165 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Cancer therapy targeting the epidermal growth factor receptor (EGFR)/erythroblastic leukemia viral oncogene B (ErbB)/human EGFR receptor (HER) family of tyrosine kinases has been successfully used in treatment of several malignancies. 28279416 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Cancer combination therapy of the sesquiterpenoid artesunate and the selective EGFR-tyrosine kinase inhibitor erlotinib. 29174651 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Cancer-associated fibroblasts promote epithelial-mesenchymal transition and EGFR-TKI resistance of non-small cell lung cancers via HGF/IGF-1/ANXA2 signaling. 29253515 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Cancer Stem Cell Biomarkers in EGFR-Mutation-Positive Non-Small-Cell Lung Cancer. 30885551 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE EGFR gene amplification was detected in 4 out of 14 malignant tumors; no low-grade astrocytoma showed amplification. 12241104 2002
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Epidermal growth factor receptor (EGFR) has attracted considerable attention as a target for cancer therapy. 12515857 2003
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs. 12826036 2003
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Epidermal growth factor receptor plays an important role in the pathogenesis of many malignancies. 15098012 2004
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression group BEFREE EGFR expression is a common feature of non-haematological malignancies and is associated with poor clinical prognosis. 15212612 2004
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Epidermal growth factor receptor (EGFR) amplification and type III mutation (EGFRvIII), associated with constitutive tyrosine kinase activation and high malignancy, are commonly observed in glioblastoma tumors. 15273741 2004
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Epidermal growth factor receptor (EGFR) and HER2/neu (HER2) tyrosine kinases have been implicated in the development and progression of several human cancers and are targets for therapeutic intervention. 16157366 2006