Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE The discovery of epidermal growth factor receptor (EGFR) activating mutations in non-small cell lung cancer (NSCLC) and the success story of EGFR tyrosine kinases inhibitors (TKIs) have changed the paradigm of cancer therapy from empirical cytotoxic chemotherapy to molecular-targeted cancer therapy. 28167215 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Collagen type I induces EGFR-TKI resistance in EGFR-mutated cancer cells by mTOR activation through Akt-independent pathway. 29701925 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Heterogeneity in Immune Marker Expression after Acquisition of Resistance to EGFR Kinase Inhibitors: Analysis of a Case with Small Cell Lung Cancer Transformation. 28193529 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE The Cancer Genome Atlas analysis revealed that somatic EGFR, receptor tyrosine-protein kinase erbB-2 (ERBB2), Erb-B2 receptor tyrosine kinase 3 (ERBB3) and Erb-B2 receptor tyrosine kinase 4 (ERBB4) gene mutations (ERBB family mutations) occur alone or co-occur with somatic mutations in the gene encoding the phosphatidylinositol 3-kinase (PI3K) catalytic subunit (PIK3CA) in 19% of human epidermal growth factor receptor 2 (HER2)-positive breast cancers. 28750640 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Overexpression of secretory phospholipase A2-IIa supports cancer stem cell phenotype via HER/ERBB-elicited signaling in lung and prostate cancer cells. 28440478 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Over 90% of head and neck cancers overexpress the epidermal growth factor receptor (EGFR). 28866730 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Epidermal growth factor receptor (EGFR) plays an important role in various types of cancer. 28535014 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Recent findings from a prospective clinical study involving multiregion whole-exome sequencing suggest that driver mutations in cancer-relevant genes including EGFR and TP53 are often clonal and precede whole-genome duplication events in early lung carcinogenesis. 28668385 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Tumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF) and Epidermal Growth Factor Receptor (EGFR) are three biomarkers that exhibit enhanced expression in many types of cancers, and have been investigated as potential biomarkers for targeted strategies and prognostication. 28841839 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Efficacy of postoperative radiotherapy in patients with pathological stage N2 epidermal growth factor receptor wild type adenocarcinoma and squamous cell carcinoma lung cancer. 27835914 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells. 28731466 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Human epidermal growth factor receptor 3 (HER3) is important in maintaining epidermal growth factor receptor-driven cancers and mediating resistance to targeted therapy. 28899363 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression group BEFREE Epidermal growth factor receptor overexpression in human cancer can be effectively targeted by drugs acting as specific inhibitors of the receptor, like erlotinib, gefitinib, cetuximab and panitumumab. 28456787 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE EGFR and HER2 are among the most promising therapeutic targets in solid cancers. 28843919 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Recent reports suggested that essential directions for new lung cancer, breast carcinoma therapies, as well as the roomier realm of targeted cancer therapies were provided through targeting the epidermal growth factor receptor (EGFR). 28075527 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Epidermal Growth Factor Receptor (EGFR) stands out as a key player in the development of many cancers. 28754471 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells. 28787001 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE The specific targeting of oncogenic mutant epidermal growth factor receptor (EGFR) is a breakthrough in targeted cancer therapy and marks a drastic change in the treatment of non-small cell lung cancer (NSCLC). 28225269 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Aberrant epidermal growth factor receptor (EGFR) signaling is widespread in cancer, making the EGFR an important target for therapy. 28604685 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Lung cancer is one of the leading causes of cancer-related death worldwide and, although targeted therapy with tyrosine kinase inhibitors has dramatically improved the rates of response and survival in advanced EGFR-mutated adenocarcinoma, the overall outcome remains unsatisfactory. 28731495 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression group BEFREE Nasopharyngeal carcinoma (NPC) is an epithelial malignancy usually associated with overexpression of both epidermal growth factor receptor (EGFR) and β-catenin. 28157708 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Investigating mutation-specific biological activities of small molecules using quantitative structure-activity relationship for epidermal growth factor receptor in cancer. 28938109 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE A widespread approach to modern cancer therapy is to identify a single oncogenic driver gene and target its mutant-protein product (for example, EGFR-inhibitor treatment in EGFR-mutant lung cancers). 29106415 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE The EGFR is one of the most popular targets for anticancer therapies and many drugs, such as erlotinib and gefitinib, have got enormous success in clinical treatments of cancer in past decade. 28504890 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker group BEFREE Cancer-associated inflammation develops resistance to the epidermal growth-factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancers (NSCLCs) harboring oncogenic EGFR mutations. 28115165 2017