Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.400 GeneticVariation group BEFREE Examining GNAS mutations could help physicians detect extra-adrenal malignancies, which may contribute to an improved prognosis for patients with this type of Cushing's syndrome. 30670014 2019
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.400 GeneticVariation group BEFREE GNAS mutations are frequently involved in IM, in contrast to these other malignant tumors. 30736805 2019
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.400 GeneticVariation group BEFREE NF1 and GNAS mutations drive acquired resistance to Hras inhibition, supporting the on-target effects of the drug.<i>Cancer Res; 78(16); 4642-57.©2018 AACR</i>. 29760048 2018
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.400 GeneticVariation group BEFREE Fibrous dysplasia (FD) is a rare bone disorder caused by mutations of the GNAS gene, which are also identified in malignancies. 28856726 2018
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.400 GeneticVariation group BEFREE Our data indicate that amplification of the GNAS locus may contribute to the pathogenesis of breast cancer, and highlight a previously unrecognised role for the GNAS XLαs variant in cancer. 23752180 2014
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.400 GeneticVariation group BEFREE Inactivating mutation of the GNAS gene is associated with several diseases, which commonly manifest heterotopic ossification and hormonal resistance; however, the development of malignant neoplasm has never been reported. 24517547 2014
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.400 GeneticVariation group BEFREE The T393C polymorphism of the GNAS1 locus, which encodes the Gαs protein, has recently been found to be associated with patient outcome in various malignancies. 21924916 2011
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.400 GeneticVariation group BEFREE The GNAS1 T393C single nucleotide polymorphism (SNP) diversely correlates with the clinical outcome in cancer. 21340746 2011
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.400 GeneticVariation group BEFREE Activating mutations lead to somatotroph, thyroid, adrenal and gonadal adenomas or the McCune-Albright syndrome and recently the T399C polymorphism in GNAS1 has been reported to be associated with malignancies. 19189654 2009
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.400 GeneticVariation group BEFREE Molecular analysis revealed that foci of malignancy and adjacent areas of hyperplasia and some areas of normal thyroid harbored activating mutations of Arg(201) in the GNAS1 gene. 12970318 2003
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.400 AlteredExpression group BEFREE Pancreatic endocrine tumours (14 out of 25), pheochromocytomas (19 out of 19), and neuroblastomas (seven out of 14) expressed NESP55, with the same strong labelling pattern in both benign and malignant tumours. 12771991 2003
Entrez Id: 2778
Gene Symbol: GNAS
GNAS
0.400 CausalMutation group CGI