Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 GeneticVariation group BEFREE In multivariable analysis, younger age, larger tumor size, and PGL were associated with malignancy (p < 0.05). 28884434 2017
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 Biomarker group BEFREE The study suggests that the underlying genetic status determines FDG uptake in PCC/PGL and not location, secretory status or malignancy. 28585398 2017
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 Biomarker group BEFREE Finally, a truncating germline <i>IDH3B</i> mutation was found in a patient with a single paraganglioma showing an altered α-ketoglutarate/isocitrate ratio.<b>Conclusions:</b> This study further attests to the relevance of the Krebs cycle in the development of PCC and PGL, and points to a potential role of other metabolic enzymes involved in metabolite exchange between mitochondria and cytosol.<i>Clin Cancer Res; 23(20); 6315-24.©2017 AACR</i>. 28720665 2017
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 GeneticVariation group BEFREE Several mutations in nuclear genes encoding for mitochondrial components have been associated with an increased cancer risk or are even causative, e.g. succinate dehydrogenase (SDHB, SDHC and SDHD genes) and iso-citrate dehydrogenase (IDH1 and IDH2 genes). 26041263 2015
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 Biomarker group BEFREE Our study suggested that SDHD mutation may enhance the overexpression of miR-101 in malignant tumors and miR-101 may be a potential diagnostic biomarker for malignant PCC and benign PCC. 25973039 2015
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 GeneticVariation group BEFREE Mutation detection rates were highest in those with a positive family history (62%), malignancy (53%), multiple tumours (33%) or PGL (44%). 23072324 2013
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 GeneticVariation group BEFREE The high frequency of founder mutations in SDHB suggests a higher prevalence of malignancy, and the SDHD mutation is usually associated with familial cases. 22566157 2012
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 Biomarker group BEFREE To clarify the potential use of SDHB immunohistochemistry as a marker of malignancy in PCC/PGL and its association with classic hypoxia signalling we examined SDHB, hypoxia inducible factor-1α (Hif-1α) and its targets CA-9 and GLUT-1 expression on protein level using immunohistochemistry on a tissue micro array on a series of familial and sporadic tumours of 115 patients. 20702724 2010
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 GeneticVariation group BEFREE The SDHD p.Cys11X mutation is a founding mutation associated with a high penetrance for paraganglial tumors of the skull base, neck, thorax, and retroperitoneum in the first four decades of life and, rarely, with malignancy. 18826997 2008
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 GeneticVariation group BEFREE Location, number of tumors, malignancy, and age were different: more carotid body tumors were found in SDHC (13/22 [59%]) than in sporadic HNPs (29/90 [32%], P = .03), as well as fewer instances of multiple tumors in SDHC (2/22) than in SDHD (24/42; P<.001), 0 malignant tumors in SDHC vs 6/15 in SDHB (P = .002), and younger age at diagnosis in SDHC than in sporadic HNPs (45 vs 52 years; P = .03). 16249420 2005
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 GeneticVariation group BEFREE Mutations in the genes encoding the three other succinate dehydrogenase subunits (SDHB, SDHC and SDHD) have been identified in patients affected by familial or 'apparently sporadic' paraganglioma and/or pheochromocytoma, an autosomal inherited cancer-susceptibility syndrome. 15795514 2005
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 Biomarker group BEFREE Phenotypes and rate of malignancy of SDHB and SDHD seem to be different, with a higher frequency of head-and-neck tumors in SDHD and indications of a higher risk of malignancy in SDHB mutations. 15883710 2005
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
0.100 Biomarker group BEFREE In order to determine whether the SDHD function plays a wider role in human malignancies, we examined SDHD gene alterations in 52 colorectal and 59 gastric cancers and 7 cancer cell lines. 12883710 2004