Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.610 GeneticVariation disease GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.610 GeneticVariation disease GWASCAT Association analyses identify 31 new risk loci for colorectal cancer susceptibility. 31089142 2019
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.610 Biomarker disease BEFREE Furthermore, Bmi-1 and Cyclin D2 were found to be positively regulated by USP22, which may have mediated the tumorigenic effects of USP22 in human colon cancer. 31612065 2019
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.610 GeneticVariation disease GWASCAT Novel Common Genetic Susceptibility Loci for Colorectal Cancer. 29917119 2019
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.610 GeneticVariation disease GWASCAT Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. 23266556 2013
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.610 Biomarker disease RGD For example, genes involved in inflammation and matrix proteases and a cell cycle regulator gene, cyclin D2, were highly expressed in colon cancers. 15059925 2004
Entrez Id: 894
Gene Symbol: CCND2
CCND2
0.610 Biomarker disease CTD_human For example, genes involved in inflammation and matrix proteases and a cell cycle regulator gene, cyclin D2, were highly expressed in colon cancers. 15059925 2004
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.600 Biomarker disease BEFREE Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists. 30931956 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.600 Biomarker disease BEFREE In addition, FPLD3-associated PPARγ mutations consistently cause intra- and/or intermolecular defects; colon cancer-associated PPARγ mutations on the other hand may play a role in colon cancer onset and progression, but this is not due to their effects on the most well-studied functional characteristics of PPARγ. 30595551 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE In particular, the PC-loaded EFM exerted its anti-cancer activity by blocking the cell cycle at the G0/G1 phase and inducing cell apoptosis involving the decrease of Bcl-2/Bax, activation of caspase 3 and release of cytochrome c. This study suggests that co-axial electrospinning is an efficient and effective way to deliver PC and improve its bioavailability; thus, it represents a promising approach for encapsulating functional ingredients for colon cancer prevention. 30806395 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.600 Biomarker disease BEFREE PTHrP treatment of colon cancer cells promotes tumor associated-angiogenesis by the effect of VEGF. 30639585 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.600 Biomarker disease BEFREE Serum vascular endothelial growth factor (VEGF) concentrations in colon cancer patients of the two groups were evaluated before and after chemotherapy. 31127996 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.600 AlteredExpression disease BEFREE This study aimed to evaluate the prognostic value of MVD in stage II and III colon cancer and its relation to tumour-stroma-percentage (TSP) and expression of HIF1A and VEGFA. 31420015 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Collectively, our results revealed that ZEB2-AS1 was upregualted and functioned as an oncogene via regulating miR-143/bcl-2 axis in colon cancer. 31497237 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Emodin activated caspases, modulated Bcl-2 family of proteins and reduced mitochondrial membrane potential to induce CoCa cell death. 31011292 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE To investigate the molecular mechanisms of cordycepin against colon cancer and in driving apoptosis, p53 and Bcl‑2‑like protein 4‑null (Bax‑/‑) colon cancer HCT116 cell lines were used. 30535479 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.600 Biomarker disease BEFREE Stimulation of colon cancer cells with VEGF-A and placental growth factor (PlGF) activated VEGF receptor-1 (VEGFR-1) and increased proliferation activity in an autocrine EGF/EGF receptor (EGF-R)-dependent manner. 31717527 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.600 Biomarker disease BEFREE Chemokine receptor 7 targets the vascular endothelial growth factor via the AKT/ERK pathway to regulate angiogenesis in colon cancer. 31348616 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.600 Biomarker disease BEFREE A gene signature comprising LAMA1, ITGB1, ITGA2, CXCR4 and VEGFA has negative predictive value in colon cancer. 29907957 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.600 Biomarker disease BEFREE The aim was to investigate the predictive value of postoperative VEGF serum concentration in patients undergoing surgery for colon cancer. 28683891 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE We have demonstrated the therapeutic potential of miR-15a in colon cancer. miR-15a inhibits several important genes (<i>BCL2, BMI1, YAP1</i> and <i>DCLK1</i>), decreasing cancer progression and resistance. 29416778 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE The present study aimed to explore the role of B-cell lymphoma 2 (BCL-2) in promoting colon cancer development associated with LIN28B. 29669301 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Targeting Bcl-2 proteins via DZNep or BH3 mimetics could increase the therapeutic potential of MDM2-antagonists like Nutlin-3a in colon cancer. 29394130 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.600 Biomarker disease BEFREE We have used 20 Male wistar rats for the formation of colon cancer model and utilized albumin as carrier molecule for the delivery of siRNA against vascular endothelial growth factor receptor 2 (VEGF R2). 29709588 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.600 AlteredExpression disease BEFREE Therefore, dihydroartemisinin inhibits colon cancer growth by inducing apoptosis and increasing the expression of PPARγ. 29472793 2018