Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5573
Gene Symbol: PRKAR1A
PRKAR1A
0.350 GeneticVariation disease BEFREE These studies support the initiation of a phase I study to evaluate the safety and potential efficacy of micromolar affinity tuned CAR T cells against newly diagnosed anaplastic and refractory or recurrent thyroid cancers. 31337787 2019
Entrez Id: 5573
Gene Symbol: PRKAR1A
PRKAR1A
0.350 GeneticVariation disease BEFREE This includes frequently reported gene fusions such as CCDC6/RET (PTC1), PRKAR1A/RET (PTC2) and ETV6/NTRK3 , and gene fusions that are less common in thyroid cancer (TPM3/NTRK1, EML4/ALK and EML4/NTRK3). 30668525 2019
Entrez Id: 5573
Gene Symbol: PRKAR1A
PRKAR1A
0.350 AlteredExpression disease BEFREE Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice. 24512487 2014
Entrez Id: 5573
Gene Symbol: PRKAR1A
PRKAR1A
0.350 GeneticVariation disease BEFREE Diagnosis of CNC occurs when two major criteria (lentiginoses, primary pigmented nodular adrenocortical disease, cardiac and cutaneous myxomas, acromegaly, testicular neoplasias, thyroid cancer) are observed and/or a major criterion associated with a supplementary criterion (affected relative, PRKAR1A gene mutation) occurs. 19169494 2008
Entrez Id: 5573
Gene Symbol: PRKAR1A
PRKAR1A
0.350 Biomarker disease BEFREE We conclude that PRKAR1A, the most abundant regulatory subunit of protein kinase A and a principal cyclic AMP-signaling modulator, acts as a tumor-suppressor gene in sporadic thyroid cancer.Published 2002 Wiley-Liss, Inc. 12203783 2002
Entrez Id: 5573
Gene Symbol: PRKAR1A
PRKAR1A
0.350 CausalMutation disease CGI