Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | TBX1 Functions as a Tumor Suppressor in Thyroid Cancer Through Inhibiting the Activities of the PI3K/AKT and MAPK/ERK Pathways. | 30543152 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | <b>Conclusions</b>: Our data demonstrate that vitamin C kills thyroid cancer cells by inhibiting MAPK/ERK and PI3K/AKT pathways via a ROS-dependent mechanism and suggest that pharmaceutical concentration of vitamin C has potential clinical use in thyroid cancer therapy. | 31285773 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Regulators of the RAS-ERK pathway as therapeutic targets in thyroid cancer. | 30978703 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | DUSP5 and DUSP6, two ERK specific phosphatases, are markers of a higher MAPK signaling activation in BRAF mutated thyroid cancers. | 28910386 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Our study illustrates a new pathway comprising iodine, miRNA and MAPK1, and defines a novel mechanism in thyroid cancer. | 28992617 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | The aim of this study is to identify its expression, function, and molecular mechanism in thyroid cancer. microRNA-137 (miR-137) downregulation was observed in thyroid cancer tissues compared with normal thyroid tissues. miR-137 mimics downregulated B-CPAP cell proliferation, colony formation ability, and invasion, with suppressed expression of cyclin E, MMP2, p-ERK, and p-AKT. miR-137 inhibitor transfection in TPC-1 cell line showed the opposite effects. | 26695142 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | These results suggest that the AMPK and p38 MAPK signaling pathways may be useful therapeutic targets to treat thyroid cancer. | 25045295 | 2014 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Thyroid cancer cell resistance to gefitinib depends on the constitutive oncogenic activation of the ERK pathway. | 23559083 | 2013 |